RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression.
Liu T, Gan H, He S, Deng J, Hu X, Li L, Cai L, He J, Long H, Cai J, Li H, Zhang Q, Wang L, Chen F, Chen Y, Zhang H, Li J, Yang L, Liu Y, Yang JH, Kuang DM, Pang P, He H, Shan H.
Liu T, et al.
Cancer Res. 2022 Sep 2;82(17):3074-3087. doi: 10.1158/0008-5472.CAN-21-3748.
Cancer Res. 2022.
PMID: 35763670
Mechanistically, DDX24 bound the mRNA618-624nt of laminin subunit beta 1 (LAMB1) and increased its stability in a manner dependent upon the interaction between nucleolin and the C-terminal region of DDX24. Moreover, regulatory factor X8 (RFX8) was identified as a DDX24 pro …
Mechanistically, DDX24 bound the mRNA618-624nt of laminin subunit beta 1 (LAMB1) and increased its stability in a manner dependent upon the …