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Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.
Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: richardson a. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1520-32. doi: 10.1152/ajpcell.00372.2009. Epub 2009 Sep 23. Am J Physiol Cell Physiol. 2009. PMID: 19776389 Free PMC article.
MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging.
Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: richardson a. Aging Cell. 2011 Jun;10(3):493-505. doi: 10.1111/j.1474-9726.2011.00695.x. Epub 2011 Apr 5. Aging Cell. 2011. PMID: 21385310 Free PMC article.
Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.
Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Jang YC, et al. Among authors: richardson a. Aging Cell. 2012 Oct;11(5):770-82. doi: 10.1111/j.1474-9726.2012.00843.x. Epub 2012 Aug 2. Aging Cell. 2012. PMID: 22672615 Free PMC article.
Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype.
Sataranatarajan K, Qaisar R, Davis C, Sakellariou GK, Vasilaki A, Zhang Y, Liu Y, Bhaskaran S, McArdle A, Jackson M, Brooks SV, Richardson A, Van Remmen H. Sataranatarajan K, et al. Among authors: richardson a. Redox Biol. 2015 Aug;5:140-148. doi: 10.1016/j.redox.2015.04.005. Epub 2015 Apr 15. Redox Biol. 2015. PMID: 25917273 Free PMC article.
3,322 results