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Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.
Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Myers SA, et al. Among authors: riegler as. Neurobiol Dis. 2019 Apr;124:353-363. doi: 10.1016/j.nbd.2018.12.008. Epub 2018 Dec 14. Neurobiol Dis. 2019. PMID: 30557659 Free PMC article.
Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury.
Saraswat Ohri S, Bankston AN, Mullins SA, Liu Y, Andres KR, Beare JE, Howard RM, Burke DA, Riegler AS, Smith AE, Hetman M, Whittemore SR. Saraswat Ohri S, et al. Among authors: riegler as. J Neurosci. 2018 Jun 27;38(26):5900-5912. doi: 10.1523/JNEUROSCI.0679-17.2018. Epub 2018 May 23. J Neurosci. 2018. PMID: 29793971 Free PMC article.