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Identification of a critical binding site for local anaesthetics in the side pockets of Kv 1 channels.
Kiper AK, Bedoya M, Stalke S, Marzian S, Ramírez D, de la Cruz A, Peraza DA, Vera-Zambrano A, Márquez Montesinos JCE, Arévalo Ramos BA, Rinné S, Gonzalez T, Valenzuela C, Gonzalez W, Decher N. Kiper AK, et al. Among authors: rinne s. Br J Pharmacol. 2021 Aug;178(15):3034-3048. doi: 10.1111/bph.15480. Epub 2021 May 14. Br J Pharmacol. 2021. PMID: 33817777 Free article.
The acid-sensitive potassium channel TASK-1 in rat cardiac muscle.
Putzke C, Wemhöner K, Sachse FB, Rinné S, Schlichthörl G, Li XT, Jaé L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-Müller R, Daut J, Decher N. Putzke C, et al. Among authors: rinne s. Cardiovasc Res. 2007 Jul 1;75(1):59-68. doi: 10.1016/j.cardiores.2007.02.025. Epub 2007 Feb 28. Cardiovasc Res. 2007. PMID: 17389142
TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes.
Limberg SH, Netter MF, Rolfes C, Rinné S, Schlichthörl G, Zuzarte M, Vassiliou T, Moosdorf R, Wulf H, Daut J, Sachse FB, Decher N. Limberg SH, et al. Among authors: rinne s. Cell Physiol Biochem. 2011;28(4):613-24. doi: 10.1159/000335757. Epub 2011 Dec 14. Cell Physiol Biochem. 2011. PMID: 22178873 Free PMC article.
Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition.
Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N. Marzian S, et al. Among authors: rinne s. Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2. Nat Chem Biol. 2013. PMID: 23728494 Free PMC article.
193 results