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Year Number of Results
1998 1
1999 2
2000 4
2001 7
2002 9
2003 8
2004 9
2005 7
2006 15
2007 20
2008 29
2009 30
2010 32
2011 37
2012 37
2013 41
2014 45
2015 57
2016 44
2017 41
2018 45
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2020 57
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2022 32
2023 42
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674 results

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Page 1
Activation of Slit2-Robo1 signaling promotes liver fibrosis.
Chang J, Lan T, Li C, Ji X, Zheng L, Gou H, Ou Y, Wu T, Qi C, Zhang Q, Li J, Gu Q, Wen D, Cao L, Qiao L, Ding Y, Wang L. Chang J, et al. J Hepatol. 2015 Dec;63(6):1413-20. doi: 10.1016/j.jhep.2015.07.033. Epub 2015 Aug 8. J Hepatol. 2015. PMID: 26264936
Liver fibrosis was induced in wild-type (WT), Slit2 transgenic (Slit2-Tg) and Robo1(+/-)Robo2(+/-) double heterozygotes (Robo1/2(+/-)) mice by carbon tetrachloride (CCl4). ...However, liver injury and hepatic expression of collagen I and alpha-SMA were attenuated in …
Liver fibrosis was induced in wild-type (WT), Slit2 transgenic (Slit2-Tg) and Robo1(+/-)Robo2(+/-) double heterozygotes (Robo1 …
Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma.
Li Q, Zhang XX, Hu LP, Ni B, Li DX, Wang X, Jiang SH, Li H, Yang MW, Jiang YS, Xu CJ, Zhang XL, Zhang YL, Huang PQ, Yang Q, Zhou Y, Gu JR, Xiao GG, Sun YW, Li J, Zhang ZG. Li Q, et al. Nat Commun. 2023 Feb 15;14(1):861. doi: 10.1038/s41467-023-36521-0. Nat Commun. 2023. PMID: 36792623 Free PMC article.
Premetastatic niche (PMN) and macrometastatic niche (MMN) formation in a mouse model is observed via CT combined with 3D organ reconstruction bioluminescence imaging, and then we screen slit guidance ligand 2 (SLIT2) and its receptor roundabout guidance receptor 1 (ROBO1) …
Premetastatic niche (PMN) and macrometastatic niche (MMN) formation in a mouse model is observed via CT combined with 3D organ reconstructio …
SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing.
Bhosle VK, Tan JM, Li T, Hua R, Kwon H, Li Z, Patel S, Tessier-Lavigne M, Robinson LA, Kim PK, Brumell JH. Bhosle VK, et al. Life Sci Alliance. 2023 Jun 13;6(8):e202301964. doi: 10.26508/lsa.202301964. Print 2023 Aug. Life Sci Alliance. 2023. PMID: 37311584 Free PMC article.
However, the mechanisms by which SLIT/ROBO signaling acts at the nexus of cellular growth control and innate immunity remain enigmatic. Here, we show that SLIT2-mediated activation of ROBO1 leads to inhibition of mTORC1 kinase activity in macrophages, leading to dephosphor …
However, the mechanisms by which SLIT/ROBO signaling acts at the nexus of cellular growth control and innate immunity remain enigmatic. Here …
Slit2/Robo1 signaling in glioma migration and invasion.
Xu Y, Li WL, Fu L, Gu F, Ma YJ. Xu Y, et al. Neurosci Bull. 2010 Dec;26(6):474-8. doi: 10.1007/s12264-010-0730-9. Neurosci Bull. 2010. PMID: 21113198 Free PMC article. Review.
Although the specific mechanisms of tumor-suppressive effect of Slit2/Robo1 have not been elucidated, it has been proved that Slit2/Robo1 signaling inhibits glioma cell migration and invasion by inactivation of Cdc42-GTP. With the research development on the molecul …
Although the specific mechanisms of tumor-suppressive effect of Slit2/Robo1 have not been elucidated, it has been proved that Slit2/ …
ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
Jin JC, Chen BY, Deng CH, Chen JN, Xu F, Tao Y, Hu CL, Xu CH, Chang BH, Wang Y, Fei MY, Liu P, Yu PC, Li ZJ, Li XY, Chen SB, Jiang YL, Chen XC, Zong LJ, Zhang JY, Ren YY, Xu FH, Liu Q, Huang XH, Guo J, He Q, Song LX, Zhou LY, Su JY, Xiao C, Zhang YM, Yan M, Zhang Z, Wu D, Chang CK, Li X, Wang L, Wu LY. Jin JC, et al. Sci Adv. 2023 Dec;9(48):eadi7375. doi: 10.1126/sciadv.adi7375. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019913 Free article.
We previously identified frequent roundabout guidance receptor 1 (ROBO1) mutations in patients with MDS, while the exact role of ROBO1 in hematopoiesis remains poorly delineated. ...Collectively, our result implicates the essential role of ROBO1 in maintainin …
We previously identified frequent roundabout guidance receptor 1 (ROBO1) mutations in patients with MDS, while the exact role of R …
Mechanism of Robo1 in the pentylenetetrazol-kindled epilepsy mouse model.
Liu Z, Huang W, Zhu MM, Xu ZX, Xu ZC, Yu CY, Huang H. Liu Z, et al. Ibrain. 2023 Aug 15;9(4):369-380. doi: 10.1002/ibra.12127. eCollection 2023 Winter. Ibrain. 2023. PMID: 38680506 Free PMC article.
Therefore, axon guidance plays a crucial role in disease progression. However, although Robo1 is one of the important components of axon guidance, the role of Robo1 in epilepsy remains unclear. ...Epileptic mice with Robo1 knockdown virus intervention had low …
Therefore, axon guidance plays a crucial role in disease progression. However, although Robo1 is one of the important components of a …
Slit2/Robo1 signaling inhibits small-cell lung cancer by targeting beta-catenin signaling in tumor cells and macrophages.
Ahirwar DK, Peng B, Charan M, Misri S, Mishra S, Kaul K, Sassi S, Gadepalli VS, Siddiqui J, Miles WO, Ganju RK. Ahirwar DK, et al. Mol Oncol. 2023 May;17(5):839-856. doi: 10.1002/1878-0261.13289. Epub 2023 Jan 10. Mol Oncol. 2023. PMID: 35838343 Free PMC article.
In addition, SLIT2 enhances M1-like and phagocytic macrophages. Molecular analysis showed that ROBO1 knockout or SLIT2 overexpression suppresses the transforming growth factor beta 1 (TGF-beta1)/beta-catenin signaling pathway in both tumor cells and macrophages. Overall, w …
In addition, SLIT2 enhances M1-like and phagocytic macrophages. Molecular analysis showed that ROBO1 knockout or SLIT2 overexpression …
Robo1 Forms a Compact Dimer-of-Dimers Assembly.
Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA. Aleksandrova N, et al. Structure. 2018 Feb 6;26(2):320-328.e4. doi: 10.1016/j.str.2017.12.003. Epub 2018 Jan 4. Structure. 2018. PMID: 29307485 Free PMC article.
However, little is known about how Slit binding mediates Robo activation. Here we present the crystal structure of Robo1 Ig1-4 and Robo1 Ig5, together with a negative stain electron microscopy reconstruction of the Robo1 ectodomain. ...We also observed no cha …
However, little is known about how Slit binding mediates Robo activation. Here we present the crystal structure of Robo1 Ig1-4 and …
ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment.
Bianchi G, Czarnecki PG, Ho M, Roccaro AM, Sacco A, Kawano Y, Gullà A, Samur AA, Chen T, Wen K, Tai YT, Moscvin M, Wu X, Camci-Unal G, Da Vià MC, Bolli N, Sewastianik T, Carrasco RD, Ghobrial IM, Anderson KC. Bianchi G, et al. Blood Cancer Discov. 2021 Jul;2(4):338-353. doi: 10.1158/2643-3230.BCD-20-0164. Blood Cancer Discov. 2021. PMID: 34268498 Free PMC article.
Through protein structure-function studies, we discovered that ROBO1 is necessary for MM adhesion to BM stromal and endothelial cells and ROBO1 knock out (KO) compromises BM homing and engraftment in a disseminated mouse model. ROBO1 KO significantly decrease …
Through protein structure-function studies, we discovered that ROBO1 is necessary for MM adhesion to BM stromal and endothelial cells …
ROBO1 polymorphisms, callosal connectivity, and reading skills.
Sun X, Song S, Liang X, Xie Y, Zhao C, Zhang Y, Shu H, Gong G. Sun X, et al. Hum Brain Mapp. 2017 May;38(5):2616-2626. doi: 10.1002/hbm.23546. Epub 2017 Feb 27. Hum Brain Mapp. 2017. PMID: 28240421 Free PMC article.
Moreover, a mediation analysis further revealed that the genu could significantly mediate the effects of the ROBO1 polymorphisms on word-list reading performance, which suggests a ROBO1-to-genu-to-reading pathway. The genu-linked cortical morphology, however, was no …
Moreover, a mediation analysis further revealed that the genu could significantly mediate the effects of the ROBO1 polymorphisms on w …
674 results