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Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.
Dong LF, Freeman R, Liu J, Zobalova R, Marin-Hernandez A, Stantic M, Rohlena J, Valis K, Rodriguez-Enriquez S, Butcher B, Goodwin J, Brunk UT, Witting PK, Moreno-Sanchez R, Scheffler IE, Ralph SJ, Neuzil J. Dong LF, et al. Among authors: rohlena j. Clin Cancer Res. 2009 Mar 1;15(5):1593-600. doi: 10.1158/1078-0432.CCR-08-2439. Epub 2009 Feb 17. Clin Cancer Res. 2009. PMID: 19223492
Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II.
Dong LF, Jameson VJ, Tilly D, Cerny J, Mahdavian E, Marín-Hernández A, Hernández-Esquivel L, Rodríguez-Enríquez S, Stursa J, Witting PK, Stantic B, Rohlena J, Truksa J, Kluckova K, Dyason JC, Ledvina M, Salvatore BA, Moreno-Sánchez R, Coster MJ, Ralph SJ, Smith RA, Neuzil J. Dong LF, et al. Among authors: rohlena j. J Biol Chem. 2011 Feb 4;286(5):3717-28. doi: 10.1074/jbc.M110.186643. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059645 Free PMC article.
Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy.
Dong LF, Jameson VJ, Tilly D, Prochazka L, Rohlena J, Valis K, Truksa J, Zobalova R, Mahdavian E, Kluckova K, Stantic M, Stursa J, Freeman R, Witting PK, Norberg E, Goodwin J, Salvatore BA, Novotna J, Turanek J, Ledvina M, Hozak P, Zhivotovsky B, Coster MJ, Ralph SJ, Smith RA, Neuzil J. Dong LF, et al. Among authors: rohlena j. Free Radic Biol Med. 2011 Jun 1;50(11):1546-55. doi: 10.1016/j.freeradbiomed.2011.02.032. Epub 2011 Mar 12. Free Radic Biol Med. 2011. PMID: 21402148
Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing.
Rohlena J, Dong LF, Kluckova K, Zobalova R, Goodwin J, Tilly D, Stursa J, Pecinova A, Philimonenko A, Hozak P, Banerjee J, Ledvina M, Sen CK, Houstek J, Coster MJ, Neuzil J. Rohlena J, et al. Antioxid Redox Signal. 2011 Dec 15;15(12):2923-35. doi: 10.1089/ars.2011.4192. Antioxid Redox Signal. 2011. PMID: 21902599 Free PMC article.
K-Ras and mitochondria: dangerous liaisons.
Neuzil J, Rohlena J, Dong LF. Neuzil J, et al. Among authors: rohlena j. Cell Res. 2012 Feb;22(2):285-7. doi: 10.1038/cr.2011.160. Epub 2011 Sep 27. Cell Res. 2012. PMID: 21946499 Free PMC article.
Mitochondrial complex II, a novel target for anti-cancer agents.
Kluckova K, Bezawork-Geleta A, Rohlena J, Dong L, Neuzil J. Kluckova K, et al. Among authors: rohlena j. Biochim Biophys Acta. 2013 May;1827(5):552-64. doi: 10.1016/j.bbabio.2012.10.015. Epub 2012 Nov 6. Biochim Biophys Acta. 2013. PMID: 23142170 Free article. Review.
57 results