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Pharmacokinetic Properties of DNA Aptamers with Base Modifications.
Gupta S, Drolet DW, Wolk SK, Waugh SM, Rohloff JC, Carter JD, Mayfield WS, Otis MR, Fowler CR, Suzuki T, Hirota M, Ishikawa Y, Schneider DJ, Janjic N. Gupta S, et al. Among authors: rohloff jc. Nucleic Acid Ther. 2017 Dec;27(6):345-353. doi: 10.1089/nat.2017.0683. Epub 2017 Sep 29. Nucleic Acid Ther. 2017. PMID: 28961063 Free PMC article.
Aptamer-based multiplexed proteomic technology for biomarker discovery.
Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, Carter J, Dalby AB, Eaton BE, Fitzwater T, Flather D, Forbes A, Foreman T, Fowler C, Gawande B, Goss M, Gunn M, Gupta S, Halladay D, Heil J, Heilig J, Hicke B, Husar G, Janjic N, Jarvis T, Jennings S, Katilius E, Keeney TR, Kim N, Koch TH, Kraemer S, Kroiss L, Le N, Levine D, Lindsey W, Lollo B, Mayfield W, Mehan M, Mehler R, Nelson SK, Nelson M, Nieuwlandt D, Nikrad M, Ochsner U, Ostroff RM, Otis M, Parker T, Pietrasiewicz S, Resnicow DI, Rohloff J, Sanders G, Sattin S, Schneider D, Singer B, Stanton M, Sterkel A, Stewart A, Stratford S, Vaught JD, Vrkljan M, Walker JJ, Watrobka M, Waugh S, Weiss A, Wilcox SK, Wolfson A, Wolk SK, Zhang C, Zichi D. Gold L, et al. PLoS One. 2010 Dec 7;5(12):e15004. doi: 10.1371/journal.pone.0015004. PLoS One. 2010. PMID: 21165148 Free PMC article.
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Davies DR, Gelinas AD, Zhang C, Rohloff JC, Carter JD, O'Connell D, Waugh SM, Wolk SK, Mayfield WS, Burgin AB, Edwards TE, Stewart LJ, Gold L, Janjic N, Jarvis TC. Davies DR, et al. Among authors: rohloff jc. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19971-6. doi: 10.1073/pnas.1213933109. Epub 2012 Nov 8. Proc Natl Acad Sci U S A. 2012. PMID: 23139410 Free PMC article.
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand.
Gelinas AD, Davies DR, Edwards TE, Rohloff JC, Carter JD, Zhang C, Gupta S, Ishikawa Y, Hirota M, Nakaishi Y, Jarvis TC, Janjic N. Gelinas AD, et al. Among authors: rohloff jc. J Biol Chem. 2014 Mar 21;289(12):8720-34. doi: 10.1074/jbc.M113.532697. Epub 2014 Jan 12. J Biol Chem. 2014. PMID: 24415767 Free PMC article.
Selection of DNA aptamers with two modified bases.
Gawande BN, Rohloff JC, Carter JD, von Carlowitz I, Zhang C, Schneider DJ, Janjic N. Gawande BN, et al. Among authors: rohloff jc. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2898-2903. doi: 10.1073/pnas.1615475114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265062 Free PMC article.
Life's simple measures: unlocking the proteome.
Brody E, Gold L, Mehan M, Ostroff R, Rohloff J, Walker J, Zichi D. Brody E, et al. J Mol Biol. 2012 Oct 5;422(5):595-606. doi: 10.1016/j.jmb.2012.06.021. Epub 2012 Jun 19. J Mol Biol. 2012. PMID: 22721953
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