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A common allosteric site and mechanism in caspases.
Scheer JM, Romanowski MJ, Wells JA. Scheer JM, et al. Among authors: romanowski mj. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7595-600. doi: 10.1073/pnas.0602571103. Epub 2006 May 8. Proc Natl Acad Sci U S A. 2006. PMID: 16682620 Free PMC article.
Full-length myocilin protein is purified from mammalian cells as a dimer.
Katoli P, Godbole A, Romanowski MJ, Clark K, Meredith E, Saenz-Vash V, Wang YK, Lewicki N, Nguyen AA, Lynch JM. Katoli P, et al. Among authors: romanowski mj. Protein Expr Purif. 2018 Jul;147:38-48. doi: 10.1016/j.pep.2018.02.008. Epub 2018 Feb 21. Protein Expr Purif. 2018. PMID: 29475084
Malonate-assisted purification of human caspases.
Scheer JM, Wells JA, Romanowski MJ. Scheer JM, et al. Among authors: romanowski mj. Protein Expr Purif. 2005 May;41(1):148-53. doi: 10.1016/j.pep.2005.01.008. Protein Expr Purif. 2005. PMID: 15802232
An allosteric circuit in caspase-1.
Datta D, Scheer JM, Romanowski MJ, Wells JA. Datta D, et al. Among authors: romanowski mj. J Mol Biol. 2008 Sep 19;381(5):1157-67. doi: 10.1016/j.jmb.2008.06.040. Epub 2008 Jun 20. J Mol Biol. 2008. PMID: 18590738 Free PMC article.
Tethering identifies fragment that yields potent inhibitors of human caspase-1.
Fahr BT, O'Brien T, Pham P, Waal ND, Baskaran S, Raimundo BC, Lam JW, Sopko MM, Purkey HE, Romanowski MJ. Fahr BT, et al. Among authors: romanowski mj. Bioorg Med Chem Lett. 2006 Feb;16(3):559-62. doi: 10.1016/j.bmcl.2005.10.048. Epub 2005 Nov 4. Bioorg Med Chem Lett. 2006. PMID: 16274992
A small-molecule inhibitor of C5 complement protein.
Jendza K, Kato M, Salcius M, Srinivas H, De Erkenez A, Nguyen A, McLaughlin D, Be C, Wiesmann C, Murphy J, Bolduc P, Mogi M, Duca J, Namil A, Capparelli M, Darsigny V, Meredith E, Tichkule R, Ferrara L, Heyder J, Liu F, Horton PA, Romanowski MJ, Schirle M, Mainolfi N, Anderson K, Michaud GA. Jendza K, et al. Among authors: romanowski mj. Nat Chem Biol. 2019 Jul;15(7):666-668. doi: 10.1038/s41589-019-0303-9. Epub 2019 Jun 17. Nat Chem Biol. 2019. PMID: 31209353
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Marcotte DJ, Liu YT, Arduini RM, Hession CA, Miatkowski K, Wildes CP, Cullen PF, Hong V, Hopkins BT, Mertsching E, Jenkins TJ, Romanowski MJ, Baker DP, Silvian LF. Marcotte DJ, et al. Among authors: romanowski mj. Protein Sci. 2010 Mar;19(3):429-39. doi: 10.1002/pro.321. Protein Sci. 2010. PMID: 20052711 Free PMC article.
Structural analysis of caspase-1 inhibitors derived from Tethering.
O'Brien T, Fahr BT, Sopko MM, Lam JW, Waal ND, Raimundo BC, Purkey HE, Pham P, Romanowski MJ. O'Brien T, et al. Among authors: romanowski mj. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt 5):451-8. doi: 10.1107/S1744309105010109. Epub 2005 Apr 9. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511067 Free PMC article.
147 results