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Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.
Samadi A, Marco-Contelles J, Soriano E, Alvarez-Pérez M, Chioua M, Romero A, González-Lafuente L, Gandía L, Roda JM, López MG, Villarroya M, García AG, Ríos Cde L. Samadi A, et al. Among authors: romero a. Bioorg Med Chem. 2010 Aug 15;18(16):5861-72. doi: 10.1016/j.bmc.2010.06.095. Epub 2010 Jul 3. Bioorg Med Chem. 2010. PMID: 20656495
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Samadi A, Valderas C, de los Ríos C, Bastida A, Chioua M, González-Lafuente L, Colmena I, Gandía L, Romero A, Del Barrio L, Martín-de-Saavedra MD, López MG, Villarroya M, Marco-Contelles J. Samadi A, et al. Among authors: romero a. Bioorg Med Chem. 2011 Jan 1;19(1):122-33. doi: 10.1016/j.bmc.2010.11.040. Epub 2010 Nov 26. Bioorg Med Chem. 2011. PMID: 21163662
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.
Maalej E, Chabchoub F, Oset-Gasque MJ, Esquivias-Pérez M, González MP, Monjas L, Pérez C, de los Ríos C, Rodríguez-Franco MI, Iriepa I, Moraleda I, Chioua M, Romero A, Marco-Contelles J, Samadi A. Maalej E, et al. Among authors: romero a. Eur J Med Chem. 2012 Aug;54:750-63. doi: 10.1016/j.ejmech.2012.06.038. Epub 2012 Jun 28. Eur J Med Chem. 2012. PMID: 22795665
Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease.
Esquivias-Pérez M, Maalej E, Romero A, Chabchoub F, Samadi A, Marco-Contelles J, Oset-Gasque MJ. Esquivias-Pérez M, et al. Among authors: romero a. Chem Res Toxicol. 2013 Jun 17;26(6):986-92. doi: 10.1021/tx400138s. Epub 2013 May 28. Chem Res Toxicol. 2013. PMID: 23676090
PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.
Lorrio S, Romero A, González-Lafuente L, Lajarín-Cuesta R, Martínez-Sanz FJ, Estrada M, Samadi A, Marco-Contelles J, Rodríguez-Franco MI, Villarroya M, López MG, de los Ríos C. Lorrio S, et al. Among authors: romero a. ACS Chem Neurosci. 2013 Sep 18;4(9):1267-77. doi: 10.1021/cn400050p. Epub 2013 Jun 13. ACS Chem Neurosci. 2013. PMID: 23763493 Free PMC article.
2,243 results