Romig H - Search Results

1

Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds.

Riether D, Zindell R, Wu L, Betageri R, Jenkins JE, Khor S, Berry AK, Hickey ER, Ermann M, Albrecht C, Ceci A, Gemkow MJ, Nagaraja NV, Romig H, Sauer A, Thomson DS. Riether D, et al. Among authors: romig h. Bioorg Med Chem Lett. 2015 Feb 1;25(3):581-6. doi: 10.1016/j.bmcl.2014.12.019. Epub 2014 Dec 13. Bioorg Med Chem Lett. 2015. PMID: 25556092

2

Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.

Bartolozzi A, Cirillo PF, Berry AK, Hickey ER, Thomson DS, Wu L, Zindell R, Albrecht C, Ceci A, Gemkow MJ, Nagaraja NV, Romig H, Sauer A, Riether D. Bartolozzi A, et al. Among authors: romig h. Bioorg Med Chem Lett. 2015 Feb 1;25(3):587-92. doi: 10.1016/j.bmcl.2014.12.031. Epub 2014 Dec 17. Bioorg Med Chem Lett. 2015. PMID: 25575658

3

Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.

Kuttruff CA, Ferrara M, Bretschneider T, Hoerer S, Handschuh S, Nosse B, Romig H, Nicklin P, Roth GJ. Kuttruff CA, et al. Among authors: romig h. ACS Med Chem Lett. 2017 Nov 8;8(12):1252-1257. doi: 10.1021/acsmedchemlett.7b00312. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259743 Free PMC article.

4

Ultrafast and Predictive Mass Spectrometry-Based Autotaxin Assays for Label-Free Potency Screening.

Bretschneider T, Luippold AH, Romig H, Bischoff D, Klinder K, Nicklin P, Rist W. Bretschneider T, et al. Among authors: romig h. SLAS Discov. 2017 Apr;22(4):425-432. doi: 10.1177/2472555217690484. Epub 2017 Feb 2. SLAS Discov. 2017. PMID: 28328321 Free article.

5

Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.

Ebenhoch R, Bauer M, Romig H, Gottschling D, Kley JT, Heine N, Weber A, Uphues I, Nar H, Pautsch A. Ebenhoch R, et al. Among authors: romig h. Acta Crystallogr D Struct Biol. 2023 Oct 1;79(Pt 10):871-880. doi: 10.1107/S2059798323006137. Epub 2023 Sep 15. Acta Crystallogr D Struct Biol. 2023. PMID: 37712434

6

Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction.

Weishaupt JH, Kussmaul L, Grötsch P, Heckel A, Rohde G, Romig H, Bähr M, Gillardon F. Weishaupt JH, et al. Among authors: romig h. Mol Cell Neurosci. 2003 Oct;24(2):489-502. doi: 10.1016/s1044-7431(03)00221-5. Mol Cell Neurosci. 2003. PMID: 14572469

7

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.

Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Müller WE. Eckert A, et al. Among authors: romig h. J Neurosci Res. 2001 Apr 15;64(2):183-92. doi: 10.1002/jnr.1064. J Neurosci Res. 2001. PMID: 11288146

8

A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.

Steiner H, Revesz T, Neumann M, Romig H, Grim MG, Pesold B, Kretzschmar HA, Hardy J, Holton JL, Baumeister R, Houlden H, Haass C. Steiner H, et al. Among authors: romig h. J Biol Chem. 2001 Mar 9;276(10):7233-9. doi: 10.1074/jbc.M007183200. Epub 2000 Nov 17. J Biol Chem. 2001. PMID: 11084029 Free article.

9

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.

Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C. Steiner H, et al. Among authors: romig h. Nat Cell Biol. 2000 Nov;2(11):848-51. doi: 10.1038/35041097. Nat Cell Biol. 2000. PMID: 11056541

10

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.

Okochi M, Eimer S, Bottcher A, Baumeister R, Romig H, Walter J, Capell A, Steiner H, Haass C. Okochi M, et al. Among authors: romig h. J Biol Chem. 2000 Dec 29;275(52):40925-32. doi: 10.1074/jbc.M005254200. J Biol Chem. 2000. PMID: 11013240 Free article.

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