Ron D - Search Results

1

Fluorescence Intensity-Based eIF2B's Guanine Nucleotide-Exchange Factor Activity Assay.

Sekine Y, Ron D, Zyryanova AF. Sekine Y, et al. Among authors: ron d. Methods Mol Biol. 2022;2428:187-196. doi: 10.1007/978-1-0716-1975-9_12. Methods Mol Biol. 2022. PMID: 35171481

2

Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

Harding HP, Zyryanova AF, Ron D. Harding HP, et al. Among authors: ron d. J Biol Chem. 2012 Dec 28;287(53):44338-44. doi: 10.1074/jbc.M112.428987. Epub 2012 Nov 12. J Biol Chem. 2012. PMID: 23148209 Free PMC article.

3

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants.

Tsunoda S, Avezov E, Zyryanova A, Konno T, Mendes-Silva L, Pinho Melo E, Harding HP, Ron D. Tsunoda S, et al. Among authors: ron d. Elife. 2014 Jul 29;3:e03421. doi: 10.7554/eLife.03421. Elife. 2014. PMID: 25073928 Free PMC article.

4

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

Avezov E, Konno T, Zyryanova A, Chen W, Laine R, Crespillo-Casado A, Melo EP, Ushioda R, Nagata K, Kaminski CF, Harding HP, Ron D. Avezov E, et al. Among authors: ron d. BMC Biol. 2015 Jan 10;13:2. doi: 10.1186/s12915-014-0112-2. BMC Biol. 2015. PMID: 25575667 Free PMC article.

5

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.

Halliday M, Radford H, Sekine Y, Moreno J, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D, Mallucci GR. Halliday M, et al. Among authors: ron d. Cell Death Dis. 2015 Mar 5;6(3):e1672. doi: 10.1038/cddis.2015.49. Cell Death Dis. 2015. PMID: 25741597 Free PMC article.

6

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

Sekine Y, Zyryanova A, Crespillo-Casado A, Fischer PM, Harding HP, Ron D. Sekine Y, et al. Among authors: ron d. Science. 2015 May 29;348(6238):1027-30. doi: 10.1126/science.aaa6986. Epub 2015 Apr 9. Science. 2015. PMID: 25858979 Free PMC article.

7

Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

Sekine Y, Zyryanova A, Crespillo-Casado A, Amin-Wetzel N, Harding HP, Ron D. Sekine Y, et al. Among authors: ron d. PLoS One. 2016 Nov 3;11(11):e0166278. doi: 10.1371/journal.pone.0166278. eCollection 2016. PLoS One. 2016. PMID: 27812215 Free PMC article.

8

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D. Zyryanova AF, et al. Among authors: ron d. Science. 2018 Mar 30;359(6383):1533-1536. doi: 10.1126/science.aar5129. Science. 2018. PMID: 29599245 Free PMC article.

9

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.

Zyryanova AF, Kashiwagi K, Rato C, Harding HP, Crespillo-Casado A, Perera LA, Sakamoto A, Nishimoto M, Yonemochi M, Shirouzu M, Ito T, Ron D. Zyryanova AF, et al. Among authors: ron d. Mol Cell. 2021 Jan 7;81(1):88-103.e6. doi: 10.1016/j.molcel.2020.10.031. Epub 2020 Nov 20. Mol Cell. 2021. PMID: 33220178 Free PMC article.

10

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.

Yan Y, Shetty M, Harding HP, George G, Zyryanova A, Labbé K, Mafi A, Hao Q, Sidrauski C, Ron D. Yan Y, et al. Among authors: ron d. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2320013121. doi: 10.1073/pnas.2320013121. Epub 2024 Mar 28. Proc Natl Acad Sci U S A. 2024. PMID: 38547060 Free PMC article.

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