Roncarolo MG - Search Results

1

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk.

Mátrai J, Cantore A, Bartholomae CC, Annoni A, Wang W, Acosta-Sanchez A, Samara-Kuko E, De Waele L, Ma L, Genovese P, Damo M, Arens A, Goudy K, Nichols TC, von Kalle C, L Chuah MK, Roncarolo MG, Schmidt M, Vandendriessche T, Naldini L. Mátrai J, et al. Among authors: roncarolo mg. Hepatology. 2011 May;53(5):1696-707. doi: 10.1002/hep.24230. Hepatology. 2011. PMID: 21520180 Free PMC article.

2

In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance.

Annoni A, Brown BD, Cantore A, Sergi LS, Naldini L, Roncarolo MG. Annoni A, et al. Among authors: roncarolo mg. Blood. 2009 Dec 10;114(25):5152-61. doi: 10.1182/blood-2009-04-214569. Blood. 2009. PMID: 19794140 Free PMC article.

3

Immune responses in liver-directed lentiviral gene therapy.

Annoni A, Goudy K, Akbarpour M, Naldini L, Roncarolo MG. Annoni A, et al. Among authors: roncarolo mg. Transl Res. 2013 Apr;161(4):230-40. doi: 10.1016/j.trsl.2012.12.018. Epub 2013 Jan 26. Transl Res. 2013. PMID: 23360745 Review.

4

Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice.

Annoni A, Cantore A, Della Valle P, Goudy K, Akbarpour M, Russo F, Bartolaccini S, D'Angelo A, Roncarolo MG, Naldini L. Annoni A, et al. Among authors: roncarolo mg. EMBO Mol Med. 2013 Nov;5(11):1684-97. doi: 10.1002/emmm.201302857. Epub 2013 Sep 16. EMBO Mol Med. 2013. PMID: 24106222 Free PMC article.

5

In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance.

Brown BD, Sitia G, Annoni A, Hauben E, Sergi LS, Zingale A, Roncarolo MG, Guidotti LG, Naldini L. Brown BD, et al. Among authors: roncarolo mg. Blood. 2007 Apr 1;109(7):2797-805. doi: 10.1182/blood-2006-10-049312. Blood. 2007. PMID: 17170119 Free article.

6

Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs.

Akbarpour M, Goudy KS, Cantore A, Russo F, Sanvito F, Naldini L, Annoni A, Roncarolo MG. Akbarpour M, et al. Among authors: roncarolo mg. Sci Transl Med. 2015 May 27;7(289):289ra81. doi: 10.1126/scitranslmed.aaa3032. Sci Transl Med. 2015. PMID: 26019217

7

Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice.

Follenzi A, Battaglia M, Lombardo A, Annoni A, Roncarolo MG, Naldini L. Follenzi A, et al. Among authors: roncarolo mg. Blood. 2004 May 15;103(10):3700-9. doi: 10.1182/blood-2003-09-3217. Epub 2003 Dec 30. Blood. 2004. PMID: 14701690 Free article.

8

The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells.

Annoni A, Battaglia M, Follenzi A, Lombardo A, Sergi-Sergi L, Naldini L, Roncarolo MG. Annoni A, et al. Among authors: roncarolo mg. Blood. 2007 Sep 15;110(6):1788-96. doi: 10.1182/blood-2006-11-059873. Epub 2007 May 10. Blood. 2007. PMID: 17495135 Free article.

9

Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy.

Goudy KS, Annoni A, Naldini L, Roncarolo MG. Goudy KS, et al. Among authors: roncarolo mg. Front Microbiol. 2011 Nov 14;2:221. doi: 10.3389/fmicb.2011.00221. eCollection 2011. Front Microbiol. 2011. PMID: 22144977 Free PMC article.

10

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell.

Biasco L, Ambrosi A, Pellin D, Bartholomae C, Brigida I, Roncarolo MG, Di Serio C, von Kalle C, Schmidt M, Aiuti A. Biasco L, et al. Among authors: roncarolo mg. EMBO Mol Med. 2011 Feb;3(2):89-101. doi: 10.1002/emmm.201000108. Epub 2011 Jan 17. EMBO Mol Med. 2011. PMID: 21243617 Free PMC article. Clinical Trial.

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