Roskos L - Search Results

1

Pharmacokinetic and pharmacodynamic comparability study of moxetumomab pasudotox, an immunotoxin targeting CD22, in cynomolgus monkeys.

Wang B, Liang M, Yao Z, Vainshtein I, Lee R, Schneider A, Zusmanovich M, Jin F, O'Connor K, Donato-Weinstein B, Iciek L, Lavallee T, Roskos L. Wang B, et al. Among authors: roskos l. J Pharm Sci. 2013 Jan;102(1):250-61. doi: 10.1002/jps.23343. Epub 2012 Oct 22. J Pharm Sci. 2013. PMID: 23090886

2

An immunoinhibition approach to overcome the impact of pre-existing antibodies on cut point establishment for immunogenicity assessment of moxetumomab pasudotox.

Schneider AK, Vainshtein I, Roskos LK, Chavez C, Sun B, Liang M. Schneider AK, et al. J Immunol Methods. 2016 Aug;435:68-76. doi: 10.1016/j.jim.2016.05.007. Epub 2016 May 21. J Immunol Methods. 2016. PMID: 27220271

3

Quantitative measurement of the target-mediated internalization kinetics of biopharmaceuticals.

Vainshtein I, Roskos LK, Cheng J, Sleeman MA, Wang B, Liang M. Vainshtein I, et al. Pharm Res. 2015 Jan;32(1):286-99. doi: 10.1007/s11095-014-1462-8. Epub 2014 Sep 11. Pharm Res. 2015. PMID: 25208874 Free PMC article.

4

Mechanistic modeling of antigen sink effect for mavrilimumab following intravenous administration in patients with rheumatoid arthritis.

Wang B, Lau YY, Liang M, Vainshtein I, Zusmanovich M, Lu H, Magrini F, Sleeman M, Roskos L. Wang B, et al. Among authors: roskos l. J Clin Pharmacol. 2012 Aug;52(8):1150-61. doi: 10.1177/0091270011412964. Epub 2011 Sep 23. J Clin Pharmacol. 2012. PMID: 21947370

5

Evaluation of assay interference and interpretation of CXCR4 receptor occupancy results in a preclinical study with MEDI3185, a fully human antibody to CXCR4.

Schwickart M, Chavez C, Henderson S, Vainshtein I, Standifer N, DelNagro C, Mehrzai F, Schneider A, Roskos L, Liang M. Schwickart M, et al. Among authors: roskos l. Cytometry B Clin Cytom. 2016 Mar;90(2):209-19. doi: 10.1002/cyto.b.21327. Epub 2015 Dec 15. Cytometry B Clin Cytom. 2016. PMID: 26384735 Free PMC article.

6

A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet-Derived Growth Factor Receptor Alpha, for Cancer Therapy.

Liang M, Wang B, Schneider A, Vainshtein I, Roskos L. Liang M, et al. Among authors: roskos l. AAPS J. 2020 Nov 18;23(1):4. doi: 10.1208/s12248-020-00523-3. AAPS J. 2020. PMID: 33210183

7

A novel approach to assess domain specificity of anti-drug antibodies to moxetumomab pasudotox, an immunotoxin with two functional domains.

Vainshtein I, Sun B, Roskos LK, Liang M. Vainshtein I, et al. J Immunol Methods. 2020 Feb;477:112688. doi: 10.1016/j.jim.2019.112688. Epub 2019 Oct 30. J Immunol Methods. 2020. PMID: 31676342

8

PK-PD modeling of protein drugs: implications in assay development.

Roskos LK, Schneider A, Vainshtein I, Schwickart M, Lee R, Lu H, Faggioni R, Liang M. Roskos LK, et al. Bioanalysis. 2011 Mar;3(6):659-75. doi: 10.4155/bio.11.28. Bioanalysis. 2011. PMID: 21417734 Review.

9

Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development.

Liang M, Schwickart M, Schneider AK, Vainshtein I, Del Nagro C, Standifer N, Roskos LK. Liang M, et al. Cytometry B Clin Cytom. 2016 Mar;90(2):117-27. doi: 10.1002/cyto.b.21259. Epub 2015 Jul 31. Cytometry B Clin Cytom. 2016. PMID: 26054054 Free PMC article. Review.

10

Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals.

Vainshtein I, Schneider AK, Sun B, Schwickart M, Roskos LK, Liang M. Vainshtein I, et al. Cytometry B Clin Cytom. 2016 Mar;90(2):128-40. doi: 10.1002/cyto.b.21319. Epub 2015 Oct 15. Cytometry B Clin Cytom. 2016. PMID: 26332491 Free PMC article.

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