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1948 1
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1,174 results

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Page 1
Non-conventional rottlerin anticancer properties.
Maioli E, Daveri E, Maellaro E, Ietta F, Cresti L, Valacchi G. Maioli E, et al. Arch Biochem Biophys. 2018 May 1;645:50-53. doi: 10.1016/j.abb.2018.03.009. Epub 2018 Mar 12. Arch Biochem Biophys. 2018. PMID: 29545132 Review.
Past and recent literature well demonstrated that rottlerin is an inhibitor of enzymes, transcription factors and signaling molecules that control cancer cell life and death. Although the rottlerin anticancer activity has been mainly ascribed to apoptosis and/or aut …
Past and recent literature well demonstrated that rottlerin is an inhibitor of enzymes, transcription factors and signaling molecules …
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies SP, Reddy H, Caivano M, Cohen P. Davies SP, et al. Biochem J. 2000 Oct 1;351(Pt 1):95-105. doi: 10.1042/0264-6021:3510095. Biochem J. 2000. PMID: 10998351 Free PMC article.
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine/threonine-specific protein kinases have been examined against a large panel of protein kinases. The compounds KT 5720, Rottlerin and quercetin were …
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine/threonine-speci …
Natural Product Rottlerin Derivatives Targeting Quorum Sensing.
Suresh D, Sabir S, Yu TT, Wenholz D, Das T, Black DS, Kumar N. Suresh D, et al. Molecules. 2021 Jun 19;26(12):3745. doi: 10.3390/molecules26123745. Molecules. 2021. PMID: 34205355 Free PMC article.
Therefore, the unique rottlerin scaffold highlights great potential in inhibiting the QS system of Pseudomonas aeruginosa. Rottlerin analogues were synthesised by modifications at its chalcone- and methylene-bridged acetophenone moieties. ...
Therefore, the unique rottlerin scaffold highlights great potential in inhibiting the QS system of Pseudomonas aeruginosa. Rottler …
The Mosaic of Rottlerin: The Sequel.
Hong KKC, Ho KKK, Bhadbhade M, Ball GE, Black DS, Kumar N. Hong KKC, et al. J Nat Prod. 2019 May 24;82(5):1190-1199. doi: 10.1021/acs.jnatprod.8b00917. Epub 2019 Apr 24. J Nat Prod. 2019. PMID: 31017784
Rottlerin (1) is a potent protein kinase C delta inhibitor that possesses a wide range of biological activities. ...In addition, the antibacterial activities of rottlerin (1) and new rottlerin analogues 32-34 were examined against Staphylococcus aureus. ...
Rottlerin (1) is a potent protein kinase C delta inhibitor that possesses a wide range of biological activities. ...In addition, the …
Rottlerin and cancer: novel evidence and mechanisms.
Maioli E, Torricelli C, Valacchi G. Maioli E, et al. ScientificWorldJournal. 2012;2012:350826. doi: 10.1100/2012/350826. Epub 2012 Jan 4. ScientificWorldJournal. 2012. PMID: 22272173 Free PMC article. Review.
The underlying mechanisms that have been described are diverse, and the final, cell-specific, Rottlerin outcome appears to result from a combination of signaling pathways at multiple levels. This paper seeks to summarize the multifocal signal modulatory properties of Ro …
The underlying mechanisms that have been described are diverse, and the final, cell-specific, Rottlerin outcome appears to result fro …
The Mosaic of Rottlerin.
Hong KK, Ball GE, Black DS, Kumar N. Hong KK, et al. J Org Chem. 2015 Nov 6;80(21):10668-74. doi: 10.1021/acs.joc.5b01827. Epub 2015 Oct 14. J Org Chem. 2015. PMID: 26426936
The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C delta (PKCdelta) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very pra …
The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C delta …
Discovery of selective and potent USP22 inhibitors via structure-based virtual screening and bioassays exerting anti-tumor activity.
Zhang Y, Song J, Zhou Y, Jia H, Zhou T, Sun Y, Gao Q, Zhao Y, Pan Y, Sun Z, Chu P. Zhang Y, et al. Bioorg Chem. 2023 Dec;141:106842. doi: 10.1016/j.bioorg.2023.106842. Epub 2023 Sep 21. Bioorg Chem. 2023. PMID: 37769523
Furthermore, Rottlerin and Morusin were found to enhance the degradation of PD-L1 and Sirt1, as well as increase the polyubiquitination of endogenous PD-L1 and Sirt1 in HCT116 cells. Moreover, in an in vivo syngeneic tumor model, Rottlerin and Morusin exhibited pote …
Furthermore, Rottlerin and Morusin were found to enhance the degradation of PD-L1 and Sirt1, as well as increase the polyubiquitinati …
Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta.
Soltoff SP. Soltoff SP. Trends Pharmacol Sci. 2007 Sep;28(9):453-8. doi: 10.1016/j.tips.2007.07.003. Epub 2007 Aug 10. Trends Pharmacol Sci. 2007. PMID: 17692392 Review.
Rottlerin has been used as a protein kinase Cdelta (PKCdelta)-selective inhibitor in hundreds of studies, on the basis of initial substrate phosphorylation studies in vitro. ...These findings indicate that there have been gross misinterpretations in studies using rottle …
Rottlerin has been used as a protein kinase Cdelta (PKCdelta)-selective inhibitor in hundreds of studies, on the basis of initial sub …
Rottlerin: bases for a possible usage in psoriasis.
Maioli E, Valacchi G. Maioli E, et al. Curr Drug Metab. 2010 Jun 1;11(5):425-30. doi: 10.2174/138920010791526097. Curr Drug Metab. 2010. PMID: 20540694 Review.
Rottlerin is a natural polyphenolic compound, which was initially indicated and marketed as a PKC delta inhibitor and recently proposed and patented as an anti-hypertensive drug. ...Herein, we will review the multiple activities of Rottlerin (antioxidant, antiprolif …
Rottlerin is a natural polyphenolic compound, which was initially indicated and marketed as a PKC delta inhibitor and recently propos …
Rottlerin, BDNF, and the impairment of inhibitory avoidance memory.
Huang WL, Hsiung MH, Dai W, Hu SS. Huang WL, et al. Psychopharmacology (Berl). 2021 Feb;238(2):421-439. doi: 10.1007/s00213-020-05690-x. Epub 2020 Nov 4. Psychopharmacology (Berl). 2021. PMID: 33146738
RATIONALE AND OBJECTIVE: As a eukaryotic elongation factor 2 kinase (eEF2K) inhibitor and a mitochondrial uncoupler, oncologists have extensively studied rottlerin. Neuroscientists, however, have accumulated scarce data on the role of rottlerin in affective and cogn …
RATIONALE AND OBJECTIVE: As a eukaryotic elongation factor 2 kinase (eEF2K) inhibitor and a mitochondrial uncoupler, oncologists have extens …
1,174 results