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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1993 1
1994 2
1995 2
1996 6
1997 4
1998 2
1999 2
2000 2
2001 2
2002 5
2003 2
2004 1
2005 8
2006 8
2007 5
2008 3
2009 3
2010 5
2011 8
2012 6
2013 8
2014 10
2015 9
2016 6
2017 5
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2020 8
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2023 14
2024 5

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164 results

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Page 1
Friend or Foe: Regulation, Downstream Effectors of RRAD in Cancer.
Sun Z, Li Y, Tan X, Liu W, He X, Pan D, Li E, Xu L, Long L. Sun Z, et al. Biomolecules. 2023 Mar 5;13(3):477. doi: 10.3390/biom13030477. Biomolecules. 2023. PMID: 36979412 Free PMC article. Review.
Additionally, RRAD in senescence may contribute to its role in cancer. Despite the twofold characters of RRAD, targeted therapies are becoming a potential therapeutic strategy to combat cancers. This review will discuss the dual identity of RRAD in specific c …
Additionally, RRAD in senescence may contribute to its role in cancer. Despite the twofold characters of RRAD, targeted therap …
NEAT1_2/RRAD/EHF Positive Feedback Loop Facilitates Aerobic Glycolysis in Papillary Thyroid Cancer Cells.
Sun W, Wang Z, Qin Y, Ji X, Huang J, Zhang F, Wang Z, Dong W, He L, Zhang H. Sun W, et al. Endocrinology. 2023 Jun 6;164(7):bqad085. doi: 10.1210/endocr/bqad085. Endocrinology. 2023. PMID: 37279586
The effects of NEAT1_2, KDM5B, RRAD, and EHF on PTC glycolysis were ascertained employing in vitro as well as in vivo experiments. ...NEAT1_2 could activate glycolysis by regulating the expression of RRAD in PTC. NEAT1_2 mediated H3K4me3 modification at the promoter …
The effects of NEAT1_2, KDM5B, RRAD, and EHF on PTC glycolysis were ascertained employing in vitro as well as in vivo experiments. .. …
RRAD expression in gastric and colorectal cancer with peritoneal carcinomatosis.
Kim HK, Lee I, Kim ST, Lee J, Kim KM, Park JO, Kang WK. Kim HK, et al. Sci Rep. 2019 Dec 19;9(1):19439. doi: 10.1038/s41598-019-55767-7. Sci Rep. 2019. PMID: 31857616 Free PMC article.
RRAD expression was frequently increased in GC and CRC cell lines, and siRNA/shRNA-mediated RRAD inhibition induced significant decline of tumor cell proliferation both in vitro and in vivo. ...Notably, RRAD expression was markedly increased in PDCs, and R …
RRAD expression was frequently increased in GC and CRC cell lines, and siRNA/shRNA-mediated RRAD inhibition induced significan …
RRAD suppresses the Warburg effect by downregulating ACTG1 in hepatocellular carcinoma.
Yan Y, Xu H, Zhang L, Zhou X, Qian X, Zhou J, Huang Y, Ge W, Wang W. Yan Y, et al. Onco Targets Ther. 2019 Feb 28;12:1691-1703. doi: 10.2147/OTT.S197844. eCollection 2019. Onco Targets Ther. 2019. PMID: 30881024 Free PMC article.
RESULTS: We demonstrated that RRAD binds to actin gamma 1 (ACTG1). RRAD suppressed aerobic glycolysis in HCC by downregulating ACTG1. ...These findings indicate that ACTG1 may act as a downstream effector of RRAD and open a new avenue for potential HCC treatm …
RESULTS: We demonstrated that RRAD binds to actin gamma 1 (ACTG1). RRAD suppressed aerobic glycolysis in HCC by downregulating …
RRAD inhibits the Warburg effect through negative regulation of the NF-kappaB signaling.
Liu J, Zhang C, Wu R, Lin M, Liang Y, Liu J, Wang X, Yang B, Feng Z. Liu J, et al. Oncotarget. 2015 Jun 20;6(17):14982-92. doi: 10.18632/oncotarget.3719. Oncotarget. 2015. PMID: 25893381 Free PMC article.
Recently, RRAD was reported to repress the Warburg effect, indicating that down-regulation of RRAD expression is an important mechanism contributing to the Warburg effect in lung cancer. However, the mechanism by which RRAD inhibits the Warburg effect remains …
Recently, RRAD was reported to repress the Warburg effect, indicating that down-regulation of RRAD expression is an important …
SETD8 inhibits ferroptosis in pancreatic cancer by inhibiting the expression of RRAD.
Lu Z, Hu Q, Qin Y, Yang H, Xiao B, Chen W, Ji S, Zu G, Wang Z, Fan G, Xu X, Chen X. Lu Z, et al. Cancer Cell Int. 2023 Mar 18;23(1):50. doi: 10.1186/s12935-023-02899-6. Cancer Cell Int. 2023. PMID: 36934248 Free PMC article.
Chromatin immunoprecipitation (CHIP) assays were used to study the molecular mechanism. RESULTS: The potential downstream target of SETD8, RRAD, was screened by RNA sequencing analysis. A negative correlation between SETD8 and RRAD was found by protein imprinting, R …
Chromatin immunoprecipitation (CHIP) assays were used to study the molecular mechanism. RESULTS: The potential downstream target of SETD8, …
RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma.
Yeom SY, Nam DH, Park C. Yeom SY, et al. Mol Cancer Ther. 2014 Dec;13(12):3049-61. doi: 10.1158/1535-7163.MCT-14-0244. Epub 2014 Oct 13. Mol Cancer Ther. 2014. PMID: 25313011
Most importantly, RRAD contributes to poor survival in patients with GBM. RRAD expression is correlated with temozolomide resistance, and, conversely, depletion of RRAD leads to sensitization of highly temozolomide-resistant GBM cells. ...These results demons …
Most importantly, RRAD contributes to poor survival in patients with GBM. RRAD expression is correlated with temozolomide resi …
RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma.
Shang R, Wang J, Sun W, Dai B, Ruan B, Zhang Z, Yang X, Gao Y, Qu S, Lv X, Tao K, Wang L, Dou K, Wang D. Shang R, et al. Tumour Biol. 2016 Apr;37(4):5097-105. doi: 10.1007/s13277-015-4329-7. Epub 2015 Nov 6. Tumour Biol. 2016. PMID: 26546438
The glucose utilization assay and lactate production assay were performed to measure the role of RRAD in HCC glycolysis. The effect of RRAD in HCC invasion and metastasis was analyzed by transwell assays. ...In addition, RRAD inhibition dramatically increased …
The glucose utilization assay and lactate production assay were performed to measure the role of RRAD in HCC glycolysis. The effect o …
RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome.
Belbachir N, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo H, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S, Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Baró I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S. Belbachir N, et al. Eur Heart J. 2019 Oct 1;40(37):3081-3094. doi: 10.1093/eurheartj/ehz308. Eur Heart J. 2019. PMID: 31114854 Free PMC article.
METHODS AND RESULTS: Whole-exome sequencing performed in a three-generation pedigree with five affected members allowed the identification of one rare non-synonymous substitution (p.R211H) in RRAD, the gene encoding the RAD GTPase, carried by all affected members of the fa …
METHODS AND RESULTS: Whole-exome sequencing performed in a three-generation pedigree with five affected members allowed the identification o …
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics.
Liu G, Papa A, Katchman AN, Zakharov SI, Roybal D, Hennessey JA, Kushner J, Yang L, Chen BX, Kushnir A, Dangas K, Gygi SP, Pitt GS, Colecraft HM, Ben-Johny M, Kalocsay M, Marx SO. Liu G, et al. Nature. 2020 Jan;577(7792):695-700. doi: 10.1038/s41586-020-1947-z. Epub 2020 Jan 22. Nature. 2020. PMID: 31969708 Free PMC article.
164 results