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Year Number of Results
1996 1
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2001 5
2002 5
2003 6
2004 5
2005 2
2006 1
2007 2
2008 3
2009 2
2010 4
2011 5
2012 1
2013 6
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2015 6
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2017 11
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2020 5
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109 results

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Page 1
Rrn3 gene knockout affects ethanol-induced locomotion in adult heterozygous zebrafish.
Li F, Lin J, Li T, Jian J, Zhang Q, Zhang Y, Liu X, Li Q. Li F, et al. Psychopharmacology (Berl). 2022 Feb;239(2):621-630. doi: 10.1007/s00213-021-06056-7. Epub 2022 Jan 10. Psychopharmacology (Berl). 2022. PMID: 35006303
Behaviourally, the locomotion and shoaling behaviour of adult rrn3(+/-) zebrafish was not significantly different compared with rrn3(+/+) zebrafish. ...The results suggest that caution should be taken when treating RRN3 heterozygous patients....
Behaviourally, the locomotion and shoaling behaviour of adult rrn3(+/-) zebrafish was not significantly different compared with rr …
High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer.
Batbayar C, Ishii N, Harimoto N, Yokobori T, Saito H, Gantumur D, Gombodorj N, Erkhem-Ochir B, Muranushi R, Hoshino K, Yamanaka T, Hagiwara K, Tsukagoshi M, Watanabe A, Araki K, Hosouchi Y, Shirabe K. Batbayar C, et al. Int J Clin Oncol. 2023 Jul;28(7):901-912. doi: 10.1007/s10147-023-02342-w. Epub 2023 Apr 29. Int J Clin Oncol. 2023. PMID: 37119370
Moreover, we evaluated RRN3 function in vitro and in vivo using proliferation, invasion, and chemosensitivity assays in PANC-1 and SW1990 cell lines, with/without depleting RRN3 expression. RESULTS: RRN3 was mainly expressed in cancer cell nuclei. High levels …
Moreover, we evaluated RRN3 function in vitro and in vivo using proliferation, invasion, and chemosensitivity assays in PANC-1 and SW …
Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.
Cavanaugh AH, Hirschler-Laszkiewicz I, Hu Q, Dundr M, Smink T, Misteli T, Rothblum LI. Cavanaugh AH, et al. J Biol Chem. 2002 Jul 26;277(30):27423-32. doi: 10.1074/jbc.M201232200. Epub 2002 May 15. J Biol Chem. 2002. PMID: 12015311 Free article.
Cycloheximide inhibits the phosphorylation of Rrn3 and causes its dissociation from RNA polymerase I. Rrn3 interacts with the rpa43 subunit of RNA polymerase I, and treatment with cycloheximide inhibits the formation of a Rrn3.rpa43 complex in vivo. Rrn3 …
Cycloheximide inhibits the phosphorylation of Rrn3 and causes its dissociation from RNA polymerase I. Rrn3 interacts with the …
Rrn3 becomes inactivated in the process of ribosomal DNA transcription.
Hirschler-Laszkiewicz I, Cavanaugh AH, Mirza A, Lun M, Hu Q, Smink T, Rothblum LI. Hirschler-Laszkiewicz I, et al. J Biol Chem. 2003 May 23;278(21):18953-9. doi: 10.1074/jbc.M301093200. Epub 2003 Mar 19. J Biol Chem. 2003. PMID: 12646563 Free article.
It has been suggested that the phosphorylation of either yeast RNA polymerase I or mammalian Rrn3 regulates the formation of RNA polymerase I.Rrn3 complexes that can interact with the committed template. ...Thus, we examined the question as to whether Rrn3 fu …
It has been suggested that the phosphorylation of either yeast RNA polymerase I or mammalian Rrn3 regulates the formation of RNA poly …
RNA polymerase I-Rrn3 complex at 4.8 A resolution.
Engel C, Plitzko J, Cramer P. Engel C, et al. Nat Commun. 2016 Jul 15;7:12129. doi: 10.1038/ncomms12129. Nat Commun. 2016. PMID: 27418309 Free PMC article.
Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I-Rrn3 complex at 4.8 A resolution. The structure reveals how Rrn3 binding converts an inactive Pol I dimer into an …
Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure …
Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.
Blattner C, Jennebach S, Herzog F, Mayer A, Cheung AC, Witte G, Lorenzen K, Hopfner KP, Heck AJ, Aebersold R, Cramer P. Blattner C, et al. Genes Dev. 2011 Oct 1;25(19):2093-105. doi: 10.1101/gad.17363311. Epub 2011 Sep 22. Genes Dev. 2011. PMID: 21940764 Free PMC article.
Cell growth is regulated during RNA polymerase (Pol) I transcription initiation by the conserved factor Rrn3/TIF-IA in yeast/humans. Here we provide a structure-function analysis of Rrn3 based on a combination of structural biology with in vivo and in vitro function …
Cell growth is regulated during RNA polymerase (Pol) I transcription initiation by the conserved factor Rrn3/TIF-IA in yeast/humans. …
Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I.
Cavanaugh AH, Evans A, Rothblum LI. Cavanaugh AH, et al. Gene Expr. 2008;14(3):131-47. Gene Expr. 2008. PMID: 18590050 Free PMC article.
We found that RNA polymerase I can be recruited to a template in the absence of active Rrn3. However, that complex will not initiate transcription, even after Rrn3 is added to the reaction. Interestingly, the complex that forms in the presence of active Rrn3 …
We found that RNA polymerase I can be recruited to a template in the absence of active Rrn3. However, that complex will not initiate …
DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.
Stepanchick A, Zhi H, Cavanaugh AH, Rothblum K, Schneider DA, Rothblum LI. Stepanchick A, et al. J Biol Chem. 2013 Mar 29;288(13):9135-44. doi: 10.1074/jbc.M112.444265. Epub 2013 Feb 7. J Biol Chem. 2013. PMID: 23393135 Free PMC article.
In the course of studying the role of Rrn3 in recruitment, we found that Rrn3 was in fact a DNA-binding protein. ...Moreover, although wild-type human Rrn3 complemented a yeast rrn3-ts mutant, the DNA-binding site mutant did not. ...
In the course of studying the role of Rrn3 in recruitment, we found that Rrn3 was in fact a DNA-binding protein. ...Moreover, …
RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template.
Yamamoto RT, Nogi Y, Dodd JA, Nomura M. Yamamoto RT, et al. EMBO J. 1996 Aug 1;15(15):3964-73. EMBO J. 1996. PMID: 8670901 Free PMC article.
RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae. ...We used extracts from a strain containing an epitope-tagged Rrn3 protein to purify a factor that could complement the mutant …
RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevis …
The NF-κB Nucleolar Stress Response Pathway.
Thoms HC, Stark LA. Thoms HC, et al. Biomedicines. 2021 Aug 25;9(9):1082. doi: 10.3390/biomedicines9091082. Biomedicines. 2021. PMID: 34572268 Free PMC article. Review.
We will also discuss activation of NF-kappaB signalling by degradation of the RNA polymerase I (PolI) complex component, transcription initiation factor-IA (TIF-IA (RRN3)), and contexts where TIF-IA-NF-kappaB signalling may be important. ...
We will also discuss activation of NF-kappaB signalling by degradation of the RNA polymerase I (PolI) complex component, transcription initi …
109 results