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Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease.
Ware MB, Zaidi MY, Yang J, Turgeon MK, Krasinskas A, Mace TA, Keenan K, Farren MR, Ruggieri AN, Li Y, Zhang C, Chen Z, Young GS, Elnaggar O, Che Z, Maithel SK, Bekaii-Saab T, El-Rayes B, Lesinski GB. Ware MB, et al. Among authors: ruggieri an. Br J Cancer. 2020 Oct;123(9):1377-1386. doi: 10.1038/s41416-020-1018-0. Epub 2020 Aug 4. Br J Cancer. 2020. PMID: 32747748 Free PMC article.
Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency.
Perdue LA, Do P, David C, Chyong A, Kellner AV, Ruggieri A, Kim HR, Salaita K, Lesinski GB, Porter CC, Dreaden EC. Perdue LA, et al. Biomacromolecules. 2020 Jul 13;21(7):2635-2644. doi: 10.1021/acs.biomac.0c00264. Epub 2020 May 29. Biomacromolecules. 2020. PMID: 32374589 Free PMC article.
Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer.
Zhang Y, Ware MB, Zaidi MY, Ruggieri AN, Olson BM, Komar H, Farren MR, Nagaraju GP, Zhang C, Chen Z, Sarmiento JM, Ahmed R, Maithel SK, El-Rayes BF, Lesinski GB. Zhang Y, et al. Among authors: ruggieri an. Mol Cancer Ther. 2021 Jan;20(1):150-160. doi: 10.1158/1535-7163.MCT-19-0911. Epub 2020 Oct 9. Mol Cancer Ther. 2021. PMID: 33037138 Free PMC article.
Multicenter randomized phase II trial of atezolizumab with or without cobimetinib in biliary tract cancers.
Yarchoan M, Cope L, Ruggieri AN, Anders RA, Noonan AM, Goff LW, Goyal L, Lacy J, Li D, Patel AK, He AR, Abou-Alfa GK, Spencer K, Kim EJ, Davis SL, McRee AJ, Kunk PR, Goyal S, Liu Y, Dennison L, Xavier S, Mohan AA, Zhu Q, Wang-Gillam A, Poklepovic A, Chen HX, Sharon E, Lesinski GB, Azad NS. Yarchoan M, et al. Among authors: ruggieri an. J Clin Invest. 2021 Dec 15;131(24):e152670. doi: 10.1172/JCI152670. J Clin Invest. 2021. PMID: 34907910 Free PMC article. Clinical Trial.
Combined MEK/PD-L1 Inhibition Alters Peripheral Cytokines and Lymphocyte Populations Correlating with Improved Clinical Outcomes in Advanced Biliary Tract Cancer.
Ruggieri AN, Yarchoan M, Goyal S, Liu Y, Sharon E, Chen HX, Olson BM, Paulos CM, El-Rayes BF, Maithel SK, Azad NS, Lesinski GB. Ruggieri AN, et al. Clin Cancer Res. 2022 Oct 3;28(19):4336-4345. doi: 10.1158/1078-0432.CCR-22-1123. Clin Cancer Res. 2022. PMID: 35833954 Free PMC article. Clinical Trial.
Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell- and CXCR3-dependent manner.
Ware MB, Phillips M, McQuinn C, Zaidi MY, Knochelmann HM, Greene E, Robinson B, Herting CJ, Mace TA, Chen Z, Zhang C, Farren MR, Ruggieri AN, Bowers JS, Shakya R, Farris AB, Young G, Carson WE 3rd, El-Rayes B, Paulos CM, Lesinski GB. Ware MB, et al. Among authors: ruggieri an. JCI Insight. 2023 Apr 24;8(8):e155006. doi: 10.1172/jci.insight.155006. JCI Insight. 2023. PMID: 36881480 Free PMC article.