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Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.
Pochampally S, Hartman KL, Wang R, Wang J, Yun MK, Parmar K, Park H, Meibohm B, White SW, Li W, Miller DD. Pochampally S, et al. ACS Pharmacol Transl Sci. 2023 Mar 22;6(4):526-545. doi: 10.1021/acsptsci.2c00108. eCollection 2023 Apr 14. ACS Pharmacol Transl Sci. 2023. PMID: 37082747 Free PMC article.
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Banerjee S, Mahmud F, Deng S, Ma L, Yun MK, Fakayode SO, Arnst KE, Yang L, Chen H, Wu Z, Lukka PB, Parmar K, Meibohm B, White SW, Wang Y, Li W, Miller DD. Banerjee S, et al. J Med Chem. 2021 Sep 9;64(17):13072-13095. doi: 10.1021/acs.jmedchem.1c01202. Epub 2021 Aug 18. J Med Chem. 2021. PMID: 34406768 Free PMC article.
55 results