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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
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2013 9
2014 7
2015 7
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2020 28
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2023 17
2024 14

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185 results

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Page 1
SAMHD1 in cancer: curse or cure?
Schott K, Majer C, Bulashevska A, Childs L, Schmidt MHH, Rajalingam K, Munder M, König R. Schott K, et al. J Mol Med (Berl). 2022 Mar;100(3):351-372. doi: 10.1007/s00109-021-02131-w. Epub 2021 Sep 4. J Mol Med (Berl). 2022. PMID: 34480199 Free PMC article. Review.
As outlined in this review, SAMHD1 has been reported to be mutated in a variety of cancer types and the expression of SAMHD1 is dysregulated in many cancers. ...The present review summarizes the negative role of SAMHD1 in chemotherapy sensitivit …
As outlined in this review, SAMHD1 has been reported to be mutated in a variety of cancer types and the expression of SAMHD …
Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies.
Wang T, Liu P, Yang J. Wang T, et al. Genes Dis. 2022 Jun 26;10(3):891-900. doi: 10.1016/j.gendis.2022.06.001. eCollection 2023 May. Genes Dis. 2022. PMID: 37396510 Free PMC article. Review.
SAMHD1 expression in acute myeloid leukemia predicts inferior prognosis. Recently, it has been revealed that SAMHD1 mediates the resistance to anti-cancer drugs. This review will focus on SAMHD1 function and regulation, the association between SAMHD …
SAMHD1 expression in acute myeloid leukemia predicts inferior prognosis. Recently, it has been revealed that SAMHD1 mediates t …
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
Mauney CH, Hollis T. Mauney CH, et al. Autoimmunity. 2018 May;51(3):96-110. doi: 10.1080/08916934.2018.1454912. Epub 2018 Mar 27. Autoimmunity. 2018. PMID: 29583030 Free PMC article. Review.
Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the severe autoimmune disease, Aicardi-Goutieres syndrome (AGS) and that are linked to cancer. Additionally, SAMHD1 functions as a restriction factor fo …
Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the severe autoimmune dise …
Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.
Li M, Zhang D, Zhu M, Shen Y, Wei W, Ying S, Korner H, Li J. Li M, et al. Rev Med Virol. 2017 Jul;27(4). doi: 10.1002/rmv.1931. Epub 2017 Apr 25. Rev Med Virol. 2017. PMID: 28444859 Review.
Here, we summarize the current knowledge about structure, antiviral mechanisms, intracellular localization, interferon-regulated expression of SAMHD1. We also describe SAMHD1-deficient animal models and an antiviral drug on the basis of disrupting proteasomal degrad …
Here, we summarize the current knowledge about structure, antiviral mechanisms, intracellular localization, interferon-regulated expression …
Targeting the Nucleotide Metabolism Proteins of the NUDIX Family and SAMHD1 in Cancer.
Forey P, Cros-Perrial E, Dumontet C, Jordheim LP. Forey P, et al. Curr Med Chem. 2021;28(21):4088-4116. doi: 10.2174/0929867328666201125120422. Curr Med Chem. 2021. PMID: 33238840 Review.
Nucleotide metabolism has been targeted for many years and in various clinical settings, including cancer. The increased knowledge of certain enzymes involved in this metabolism and associated cellular processes accumulated over the last few years, gives important informat …
Nucleotide metabolism has been targeted for many years and in various clinical settings, including cancer. The increased knowledge of …
Expression of SAMHD1 and its mutation on prognosis of colon cancer.
Zhang Z, Li P, Sun P. Zhang Z, et al. Oncol Lett. 2022 Jul 8;24(3):303. doi: 10.3892/ol.2022.13423. eCollection 2022 Sep. Oncol Lett. 2022. PMID: 35949607 Free PMC article.
The expression of sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) and its mutation play a key role in the prognosis of colon cancer. ...IHC and IF results demonstrated that SAMHD1 expression in patients with colon cance …
The expression of sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) and its mutation play a key ro …
SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis.
Gutiérrez-Chamorro L, Felip E, Bernat-Peguera A, Ezeonwumelu IJ, Teruel I, Martínez-Cardús A, Clotet B, Riveira-Muñoz E, Romeo M, Margelí M, Ballana E. Gutiérrez-Chamorro L, et al. Front Immunol. 2023 Feb 9;14:1112761. doi: 10.3389/fimmu.2023.1112761. eCollection 2023. Front Immunol. 2023. PMID: 36845138 Free PMC article.
Here, we evaluate SAMHD1 function in ovarian cancer, both in vitro and in ovarian cancer patients. METHODS: SAMHD1 expression was downregulated in ovarian cancer cell lines OVCAR3 and SKOV3 by RNA interference. ...
Here, we evaluate SAMHD1 function in ovarian cancer, both in vitro and in ovarian cancer patients. METHODS: SAMHD1 …
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.
Kapoor-Vazirani P, Rath SK, Liu X, Shu Z, Bowen NE, Chen Y, Haji-Seyed-Javadi R, Daddacha W, Minten EV, Danelia D, Farchi D, Duong DM, Seyfried NT, Deng X, Ortlund EA, Kim B, Yu DS. Kapoor-Vazirani P, et al. Nat Commun. 2022 Nov 7;13(1):6707. doi: 10.1038/s41467-022-34578-x. Nat Commun. 2022. PMID: 36344525 Free PMC article.
SIRT1 complexes with and deacetylates SAMHD1 at conserved lysine 354 (K354) specifically in response to DSBs. K354 deacetylation by SIRT1 promotes DNA end resection and HR but not SAMHD1 tetramerization or dNTPase activity. Mechanistically, K354 deacetylation by SIR …
SIRT1 complexes with and deacetylates SAMHD1 at conserved lysine 354 (K354) specifically in response to DSBs. K354 deacetylation by S …
Defective modulation of LINE-1 retrotransposition by cancer-associated SAMHD1 mutants.
Gao W, Li G, Bian X, Rui Y, Zhai C, Liu P, Su J, Wang H, Zhu C, Du Y, Zheng W, Zheng B, Zhang W, Zhang H, Zhao K, Yang Y, Yu X. Gao W, et al. Biochem Biophys Res Commun. 2019 Nov 5;519(2):213-219. doi: 10.1016/j.bbrc.2019.08.155. Epub 2019 Sep 4. Biochem Biophys Res Commun. 2019. PMID: 31492497
SAMHD1 has been reported to be a potent inhibitor of LINE-1 retrotransposition, and SAMHD1 mutations are frequently associated with cancer development. ...Most of the tested SAMHD1 cancer-related mutations were defective in LINE-1 inhibition. .. …
SAMHD1 has been reported to be a potent inhibitor of LINE-1 retrotransposition, and SAMHD1 mutations are frequently associated …
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Cai Y, Chen X, Lu T, Fang X, Ding M, Yu Z, Hu S, Liu J, Zhou X, Wang X. Cai Y, et al. Int J Biol Sci. 2023 Aug 28;19(14):4627-4643. doi: 10.7150/ijbs.85236. eCollection 2023. Int J Biol Sci. 2023. PMID: 37781035 Free PMC article.
High level of SAMHD1 was associated with poor prognosis in DLBCL patients. Down-regulation of SAMHD1 inhibited DLBCL cell proliferation both in vitro and in vivo. Moreover, we found that SAMHD1 deficiency induced DNA damage and promoted the expression of DNA …
High level of SAMHD1 was associated with poor prognosis in DLBCL patients. Down-regulation of SAMHD1 inhibited DLBCL cell prol …
185 results