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Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?
Theoharides TC. Theoharides TC. Mol Neurobiol. 2022 Mar;59(3):1850-1861. doi: 10.1007/s12035-021-02696-0. Epub 2022 Jan 13. Mol Neurobiol. 2022. PMID: 35028901 Free PMC article. Review.
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells and results in acute symptoms involving especially the lungs known as COVID-19. ...Most of the vaccines produced so far for COVID-19 direct mammalian cells via eith …
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells and results in acute sym …
Be aware of SARS-CoV-2 spike protein: There is more than meets the eye.
Theoharides TC, Conti P. Theoharides TC, et al. J Biol Regul Homeost Agents. 2021 May-Jun;35(3):833-838. doi: 10.23812/THEO_EDIT_3_21. J Biol Regul Homeost Agents. 2021. PMID: 34100279
The best well-known vaccines have utilized either mRNA or an adenovirus vector to direct human cells to produce the spike protein against which the body produces mostly neutralizing antibodies. However, recent reports have raised some skepticism as to the bio …
The best well-known vaccines have utilized either mRNA or an adenovirus vector to direct human cells to produce the spike p …
A comprehensive review of SARS-CoV-2 vaccines: Pfizer, Moderna & Johnson & Johnson.
Patel R, Kaki M, Potluri VS, Kahar P, Khanna D. Patel R, et al. Hum Vaccin Immunother. 2022 Dec 31;18(1):2002083. doi: 10.1080/21645515.2021.2002083. Epub 2022 Feb 7. Hum Vaccin Immunother. 2022. PMID: 35130825 Free PMC article. Review.
We are reviewing the COVID-19 vaccines authorized for use in the United States by discussing the mechanisms of action, administration, side effects, and efficacy of vaccines developed by Pfizer, Moderna, and Johnson & Johnson. Pfizer and Moderna developed mRNA vaccines, encod …
We are reviewing the COVID-19 vaccines authorized for use in the United States by discussing the mechanisms of action, administration, side …
Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways.
Kircheis R. Kircheis R. Int J Mol Sci. 2021 Oct 6;22(19):10791. doi: 10.3390/ijms221910791. Int J Mol Sci. 2021. PMID: 34639132 Free PMC article. Review.
Novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digit infection rates and thousands of death tolls daily. Enormous efforts are undertaken to achieve high coverage of immunization to reach herd immunity in order to stop the spread of SARS …
Novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digit infection rates and thousands of death tolls da …
Adenovirus Vaccine Containing Truncated SARS-CoV-2 Spike Protein S1 Subunit Leads to a Specific Immune Response in Mice.
Chen K, Shi D, Li C, Fang Z, Guo Y, Jiang W, Li J, Li H, Yao H. Chen K, et al. Vaccines (Basel). 2023 Feb 13;11(2):429. doi: 10.3390/vaccines11020429. Vaccines (Basel). 2023. PMID: 36851306 Free PMC article.
The protein was tested to determine if it could elicit efficient immunization in mice against SARS-CoV-2. ...SARS-CoV-2 S1 protein humoral immunity was demonstrated in all immunized mice. ...
The protein was tested to determine if it could elicit efficient immunization in mice against SARS-CoV-2. ...SARS-CoV-2 …
Thrombosis and thrombocytopenia in COVID-19 and after COVID-19 vaccination.
Iba T, Levy JH. Iba T, et al. Trends Cardiovasc Med. 2022 Jul;32(5):249-256. doi: 10.1016/j.tcm.2022.02.008. Epub 2022 Feb 22. Trends Cardiovasc Med. 2022. PMID: 35202800 Free PMC article. Review.
Although thrombocytopenia is uncommon in the initial presentation, it may also reflect disease severity due to the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to activate platelets. This occurs directly through the spike protein-an …
Although thrombocytopenia is uncommon in the initial presentation, it may also reflect disease severity due to the ability of severe acute r …
Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19.
Sadoff J, Gray G, Vandebosch A, Cárdenas V, Shukarev G, Grinsztejn B, Goepfert PA, Truyers C, Fennema H, Spiessens B, Offergeld K, Scheper G, Taylor KL, Robb ML, Treanor J, Barouch DH, Stoddard J, Ryser MF, Marovich MA, Neuzil KM, Corey L, Cauwenberghs N, Tanner T, Hardt K, Ruiz-Guiñazú J, Le Gars M, Schuitemaker H, Van Hoof J, Struyf F, Douoguih M; ENSEMBLE Study Group. Sadoff J, et al. N Engl J Med. 2021 Jun 10;384(23):2187-2201. doi: 10.1056/NEJMoa2101544. Epub 2021 Apr 21. N Engl J Med. 2021. PMID: 33882225 Free PMC article. Clinical Trial.
BACKGROUND: The Ad26.COV2.S vaccine is a recombinant, replication-incompetent human adenovirus type 26 vector encoding full-length severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein in a prefusion-stabilized conformation. ...The …
BACKGROUND: The Ad26.COV2.S vaccine is a recombinant, replication-incompetent human adenovirus type 26 vector encoding full-length se …
The Chimeric Adenovirus (Ad5/35) Expressing Engineered Spike Protein Confers Immunity against SARS-CoV-2 in Mice and Non-Human Primates.
Shin SP, Shin KS, Lee JM, Jung IK, Koo J, Lee SW, Park S, Shin J, Park M, Park B, Oh H, Koo BS, Hong J, Ryu CM, Kim JO, Oh T, Kang CY. Shin SP, et al. Vaccines (Basel). 2022 Apr 30;10(5):712. doi: 10.3390/vaccines10050712. Vaccines (Basel). 2022. PMID: 35632468 Free PMC article.
Here, we constructed AdCLD-CoV19 that could modulate humoral immunity by harboring SARS-CoV-2 antigens onto a chimeric adenovirus 5/35 platform that was effective in cellular immunity. By replacing the S1/S2 furin cleavage sequence of the SARS-CoV-2 Spike …
Here, we constructed AdCLD-CoV19 that could modulate humoral immunity by harboring SARS-CoV-2 antigens onto a chimeric adenovirus …
Heterologous chimpanzee adenovirus vector immunizations for SARS-CoV-2 spike and nucleocapsid protect hamsters against COVID-19.
Hasanpourghadi M, Novikov M, Ambrose R, Chekaoui A, Newman D, Ding J, Giles-Davis W, Xiang Z, Zhou XY, Liu Q, Swagata K, Ertl HC. Hasanpourghadi M, et al. Microbes Infect. 2023 May;25(4):105082. doi: 10.1016/j.micinf.2022.105082. Epub 2022 Dec 17. Microbes Infect. 2023. PMID: 36539010 Free PMC article.
Available COVID-19 vaccine only provide protection for a limited time due in part to the rapid emergence of viral variants with spike protein mutations, necessitating the generation of new vaccines to combat SARS-CoV-2. Two serologically distinct replication- …
Available COVID-19 vaccine only provide protection for a limited time due in part to the rapid emergence of viral variants with spike …
Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2.
Jung HE, Ku KB, Kang BH, Park JH, Kim HC, Kim KD, Lee HK. Jung HE, et al. Antiviral Res. 2023 Aug;216:105656. doi: 10.1016/j.antiviral.2023.105656. Epub 2023 Jun 14. Antiviral Res. 2023. PMID: 37327877 Free PMC article.
The ongoing COVID-19 pandemic caused by SARS-CoV-2 infection has threatened global health. Since the first case of infection was reported in December 2019, SARS-CoV-2 has rapidly spread worldwide and caused millions of deaths. ...Additionally, traditional intramuscu …
The ongoing COVID-19 pandemic caused by SARS-CoV-2 infection has threatened global health. Since the first case of infection was repo …
292 results