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4,396 results

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Page 1
A Multimodal Scaffold for SDF1 Delivery Improves Cardiac Function in a Rat Subacute Myocardial Infarct Model.
Perez-Estenaga I, Chevalier MT, Peña E, Abizanda G, Alsharabasy AM, Larequi E, Cilla M, Perez MM, Gurtubay J, Garcia-Yebenes Castro M, Prosper F, Pandit A, Pelacho B. Perez-Estenaga I, et al. ACS Appl Mater Interfaces. 2023 Aug 11;15(44):50638-51. doi: 10.1021/acsami.3c04245. Online ahead of print. ACS Appl Mater Interfaces. 2023. PMID: 37566441 Free PMC article. Review.
In this study, a collagen hydrogel that is able to load and appropriately deliver pro-angiogenic stromal cell-derived factor 1 (SDF1) was physically coupled with a compact collagen membrane in order to provide the suture strength required for surgical implantation. ...More …
In this study, a collagen hydrogel that is able to load and appropriately deliver pro-angiogenic stromal cell-derived factor 1 (SDF1) …
Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs.
Haque N, Fareez IM, Fong LF, Mandal C, Abu Kasim NH, Kacharaju KR, Soesilawati P. Haque N, et al. World J Stem Cells. 2020 Sep 26;12(9):938-951. doi: 10.4252/wjsc.v12.i9.938. World J Stem Cells. 2020. PMID: 33033556 Free PMC article. Review.
Of these different paracrine factors present within the secretome, researchers have given proper consideration to stromal cell-derived factor-1 (SDF1) that plays a vital role in tissue-specific migration of the cells needed for regeneration. Recently researchers recognized …
Of these different paracrine factors present within the secretome, researchers have given proper consideration to stromal cell-derived facto …
SDF1/CXCR4 axis facilitates the angiogenesis via activating the PI3K/AKT pathway in degenerated discs.
Zhang H, Wang P, Zhang X, Zhao W, Ren H, Hu Z. Zhang H, et al. Mol Med Rep. 2020 Nov;22(5):4163-4172. doi: 10.3892/mmr.2020.11498. Epub 2020 Sep 9. Mol Med Rep. 2020. Retraction in: Mol Med Rep. 2024 Nov;30(5):207. doi: 10.3892/mmr.2024.13331. PMID: 32901877 Free PMC article. Retracted.
Moreover, SDF1 has been identified to induce neovascularization in rheumatoid arthritis disease. ...Adenovirus infection was used to upregulate SDF1 expression in primary nucleus pulposus cells (NPCs). The effects of SDF1 on the proliferation and angiogenesis …
Moreover, SDF1 has been identified to induce neovascularization in rheumatoid arthritis disease. ...Adenovirus infection was used to …
Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.
Chen Y, Liu J, Zhang Q, Chai L, Chen H, Li D, Wang Y, Qiu Y, Shen N, Zhang J, Wang Q, Wang J, Xie X, Li S, Li M. Chen Y, et al. Eur J Pharmacol. 2024 May 5;970:176483. doi: 10.1016/j.ejphar.2024.176483. Epub 2024 Mar 11. Eur J Pharmacol. 2024. PMID: 38479721
Stromal derived factor 1 (SDF1) has been shown to be involved in the pathogenesis of pulmonary artery hypertension (PAH). ...Our study provides novel sights for SDF1 induction of PASMCs proliferation and suggests that targeting SDF1/CaMKII/HDAC4/Runx2 axis ha …
Stromal derived factor 1 (SDF1) has been shown to be involved in the pathogenesis of pulmonary artery hypertension (PAH). ...Our stud …
SDF1-CXCR4 Signaling Contributes to the Transition from Acute to Chronic Pain State.
Yang F, Sun W, Luo WJ, Yang Y, Yang F, Wang XL, Chen J. Yang F, et al. Mol Neurobiol. 2017 May;54(4):2763-2775. doi: 10.1007/s12035-016-9875-5. Epub 2016 Mar 24. Mol Neurobiol. 2017. PMID: 27011380
Emerging evidence has demonstrated the involvement of stromal cell-derived factor 1 (SDF1, also known as CXCL12)-CXCR4 signaling in a variety of pain state. However, the underlying mechanisms of SDF1-CXCR4 signaling leading to the maintenance of chronic pain states …
Emerging evidence has demonstrated the involvement of stromal cell-derived factor 1 (SDF1, also known as CXCL12)-CXCR4 signaling in a …
Role of stromal cell-derived factor 1 (SDF1/CXCL12) in regulating anterior pituitary function.
Barbieri F, Bajetto A, Porcile C, Pattarozzi A, Schettini G, Florio T. Barbieri F, et al. J Mol Endocrinol. 2007 Mar;38(3):383-9. doi: 10.1677/JME-06-0014. J Mol Endocrinol. 2007. PMID: 17339401 Review.
SDF1 and its receptor CXCR4 were identified in both neurons and glia of many brain areas, including the hypothalamus, as well as at the pituitary level. Importantly, SDF1 and CXCR4 expression is increased in brain tumors in which their activity induced tumor cell pr …
SDF1 and its receptor CXCR4 were identified in both neurons and glia of many brain areas, including the hypothalamus, as well as at t …
SDF1/CXCR4 axis plays a role in angiogenesis during the degeneration of intervertebral discs.
Zhang H, He B. Zhang H, et al. Mol Med Rep. 2019 Aug;20(2):1203-1211. doi: 10.3892/mmr.2019.10346. Epub 2019 Jun 5. Mol Med Rep. 2019. PMID: 31173219 Free PMC article.
The present study aimed to investigate the influence and relative mechanism of stromal cell derived factor 1 (SDF1) on the angiogenesis of degenerated intervertebral discs. The expression of SDF1 in nucleus pulposus cells (NPCs) was upregulated and downregulated by …
The present study aimed to investigate the influence and relative mechanism of stromal cell derived factor 1 (SDF1) on the angiogenes …
Supplementation of SDF1 during Pig Oocyte In Vitro Maturation Improves Subsequent Embryo Development.
Zhao H, Dong Y, Zhang Y, Wu X, Zhang X, Liang Y, Li Y, Zeng F, Shi J, Zhou R, Hong L, Cai G, Wu Z, Li Z. Zhao H, et al. Molecules. 2022 Oct 12;27(20):6830. doi: 10.3390/molecules27206830. Molecules. 2022. PMID: 36296422 Free PMC article.
The developmental potential of in vitro matured oocytes is usually impaired due to oxidative stress. Stromal cell-derived factor-l (SDF1) can reduce oxidative stress and inhibit apoptosis. The aim of this study was to investigate the effects of SDF1 supplementation …
The developmental potential of in vitro matured oocytes is usually impaired due to oxidative stress. Stromal cell-derived factor-l (SDF1 …
Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion.
Xie L, Cen LP, Li Y, Gilbert HY, Strelko O, Berlinicke C, Stavarache MA, Ma M, Wang Y, Cui Q, Kaplitt MG, Zack DJ, Benowitz LI, Yin Y. Xie L, et al. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2113751119. doi: 10.1073/pnas.2113751119. Epub 2022 Apr 8. Proc Natl Acad Sci U S A. 2022. PMID: 35394873 Free PMC article.
SDF1 deficiency in myeloid cells (CXCL12flx/flxLysM-Cre/+ mice) or deletion of the SDF1 receptor CXCR4 in RGCs (intraocular AAV2-Cre in CXCR4flx/flx mice) or SDF1 antagonist AMD3100 greatly suppresses inflammation-induced regeneration and decreases RGC surviv …
SDF1 deficiency in myeloid cells (CXCL12flx/flxLysM-Cre/+ mice) or deletion of the SDF1 receptor CXCR4 in RGCs (intraocular AA …
SDF1-a facilitates Lin-/Sca1+ cell homing following murine experimental cerebral ischemia.
Mocco J, Afzal A, Ansari S, Wolfe A, Caldwell K, Connolly ES, Scott EW. Mocco J, et al. PLoS One. 2014 Jan 20;9(1):e85615. doi: 10.1371/journal.pone.0085615. eCollection 2014. PLoS One. 2014. PMID: 24465621 Free PMC article.
METHODS: Animals underwent a murine intraluminal filament model of focal cerebral ischemia and the SDF1-A pathway was evaluated in a blinded manner via serum and brain SDF1-A level assessment, Lin-/Sca1+ cell mobilization quantification, and exogenous cell migration …
METHODS: Animals underwent a murine intraluminal filament model of focal cerebral ischemia and the SDF1-A pathway was evaluated in a …
4,396 results