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SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune Microenvironment.
Zhang D, Lindstrom A, Kim EJ, Hwang CI, Hall ML, Lin TY, Li Y. Zhang D, et al. Front Oncol. 2022 Jun 16;12:890154. doi: 10.3389/fonc.2022.890154. eCollection 2022. Front Oncol. 2022. PMID: 35785187 Free PMC article.
In pancreatic cancer cells, SEMA3C knockdown or inhibition exhibited growth/colony inhibition and cell cycle arrest. In addition, SEMA3C inhibition sensitized KRAS or MEK1/2 inhibition in pancreatic cancer cells. ...
In pancreatic cancer cells, SEMA3C knockdown or inhibition exhibited growth/colony inhibition and cell cycle arrest. In additi …
SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.
Liu R, Shuai Y, Luo J, Zhang Z. Liu R, et al. Front Oncol. 2019 Oct 9;9:1035. doi: 10.3389/fonc.2019.01035. eCollection 2019. Front Oncol. 2019. PMID: 31649890 Free PMC article.
Introduction: Aberrant activation of Semaphorin3C(SEMA3C) is widespread in human cancers. We aimed to analyze SEMA3C expression in cervical cancer and investigate the role of SEMA3C in cervical cancer and its underlying mechanism, which i …
Introduction: Aberrant activation of Semaphorin3C(SEMA3C) is widespread in human cancers. We aimed to analyze SEMA3C ex …
SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1.
Peacock JW, Takeuchi A, Hayashi N, Liu L, Tam KJ, Al Nakouzi N, Khazamipour N, Tombe T, Dejima T, Lee KC, Shiota M, Thaper D, Lee WC, Hui DH, Kuruma H, Ivanova L, Yenki P, Jiao IZ, Khosravi S, Mui AL, Fazli L, Zoubeidi A, Daugaard M, Gleave ME, Ong CJ. Peacock JW, et al. EMBO Mol Med. 2018 Feb;10(2):219-238. doi: 10.15252/emmm.201707689. EMBO Mol Med. 2018. PMID: 29348142 Free PMC article.
SEMA3C expression levels increase in castration-resistant prostate cancer (CRPC), where it functions to promote cancer cell growth and resistance to androgen receptor pathway inhibition. ...Plexin B1 sema domain-containing:Fc fusion proteins suppress RTK sign …
SEMA3C expression levels increase in castration-resistant prostate cancer (CRPC), where it functions to promote cancer …
MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling.
Yin L, Li J, Wang J, Pu T, Wei J, Li Q, Wu BJ. Yin L, et al. Oncogene. 2021 Feb;40(7):1362-1374. doi: 10.1038/s41388-020-01615-2. Epub 2021 Jan 8. Oncogene. 2021. PMID: 33420365 Free PMC article.
Perineural invasion (PNI), a pathologic feature defined as cancer cell invasion in, around, and through nerves, is an indicator of poor prognosis and survival in prostate cancer (PC). ...MAOA promotes PNI of PC cells in vitro and tumor innervation in an orthotopic x …
Perineural invasion (PNI), a pathologic feature defined as cancer cell invasion in, around, and through nerves, is an indicator of po …
Semaphorin 3C exacerbates liver fibrosis.
De Angelis Rigotti F, Wiedmann L, Hubert MO, Vacca M, Hasan SS, Moll I, Carvajal S, Jiménez W, Starostecka M, Billeter AT, Müller-Stich B, Wolff G, Ekim-Üstünel B, Herzig S, Fandos-Ramo C, Krätzner R, Reich M, Keitel-Anselmino V, Heikenwälder M, Mogler C, Fischer A, Rodriguez-Vita J. De Angelis Rigotti F, et al. Hepatology. 2023 Oct 1;78(4):1092-1105. doi: 10.1097/HEP.0000000000000407. Epub 2023 Apr 15. Hepatology. 2023. PMID: 37055018
In keeping with this, deletion of SEMA3C in activated HSCs reduces myofibroblast marker expression. ...Among SEMA3C receptors, only NRP2 expression is maintained on activation of isolated HSCs. ...
In keeping with this, deletion of SEMA3C in activated HSCs reduces myofibroblast marker expression. ...Among SEMA3C receptors, …
Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.
Hao J, Han X, Huang H, Yu X, Fang J, Zhao J, Prayson RA, Bao S, Yu JS. Hao J, et al. Nat Commun. 2023 Apr 20;14(1):2262. doi: 10.1038/s41467-023-37397-w. Nat Commun. 2023. PMID: 37080989 Free PMC article.
Sema3C-driven Wnt signaling occurred despite suppression of Wnt ligand secretion, suggesting that Sema3C drives canonical Wnt signaling independent of Wnt ligand binding. ...Since Sema3C is frequently overexpressed in glioblastoma, Sema3C signaling may …
Sema3C-driven Wnt signaling occurred despite suppression of Wnt ligand secretion, suggesting that Sema3C drives canonical Wnt …
Dependency of Tamoxifen Sensitive and Resistant ER(+) Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth.
Bhasin S, Dusek C, Peacock JW, Cherkasov A, Wang Y, Gleave M, Ong CJ. Bhasin S, et al. Cells. 2023 Jun 25;12(13):1715. doi: 10.3390/cells12131715. Cells. 2023. PMID: 37443749 Free PMC article.
Treatment with B1SP Fc fusion protein, a SEMA3C pathway inhibitor, attenuated SEMA3C-induced signaling and growth across a panel of tamoxifen sensitive and resistant ER(+) breast cancer cells. ...Here, our study implicates SEMA3C in a functional role i …
Treatment with B1SP Fc fusion protein, a SEMA3C pathway inhibitor, attenuated SEMA3C-induced signaling and growth across a pan …
Sema3C promotes hepatic metastasis and predicts poor prognosis in gastric adenocarcinoma.
Li M, Xu D, Xia X, Ni B, Zhu C, Zhao G, Cao H. Li M, et al. J Int Med Res. 2021 Apr;49(4):3000605211009802. doi: 10.1177/03000605211009802. J Int Med Res. 2021. PMID: 33909533 Free PMC article.
METHODS: Sema3C expression in gastric cancer (GC) cell lines and tissues was measured using RT-qPCR and western blotting. ...Moreover, Sema3C expression was positively correlated with clinicopathological features in GC and paired hepatic metastatic tissues, a …
METHODS: Sema3C expression in gastric cancer (GC) cell lines and tissues was measured using RT-qPCR and western blotting. ...M …
SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling.
Yenki P, Adomat HH, Ong CJ. Yenki P, et al. Prostate. 2021 May;81(6):309-317. doi: 10.1002/pros.24107. Epub 2021 Jan 27. Prostate. 2021. PMID: 33503318
Also, to test SEMA3C's effect on the conversion of DHEA to androgens, we exposed PrSCs to the conditioned media derived from LNCaP cells that were transduced with a lentiviral vector harboring full length SEMA3C gene or empty vector (CM-LN(SEMA3C) or CM-LN(Ve …
Also, to test SEMA3C's effect on the conversion of DHEA to androgens, we exposed PrSCs to the conditioned media derived from LNCaP ce …
Emerging roles and mechanisms of semaphorins activity in cancer.
Bica C, Tirpe A, Nutu A, Ciocan C, Chira S, Gurzau ES, Braicu C, Berindan-Neagoe I. Bica C, et al. Life Sci. 2023 Apr 1;318:121499. doi: 10.1016/j.lfs.2023.121499. Epub 2023 Feb 10. Life Sci. 2023. PMID: 36775114 Review.
Semaphorins are regulatory molecules that are linked to the modulation of several cancer processes, such as angiogenesis, cancer cell invasiveness and metastasis, tumor growth, as well as cancer cell survival. ...SEMA3A, SEMA3B) function widely as tumor suppr …
Semaphorins are regulatory molecules that are linked to the modulation of several cancer processes, such as angiogenesis, cancer …
80 results