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The role of SETD1A and SETD1B in development and disease.
Kranz A, Anastassiadis K. Kranz A, et al. Biochim Biophys Acta Gene Regul Mech. 2020 Aug;1863(8):194578. doi: 10.1016/j.bbagrm.2020.194578. Epub 2020 May 8. Biochim Biophys Acta Gene Regul Mech. 2020. PMID: 32389824 Review.
SETD1A is required shortly after epiblast formation whereas SETD1B becomes indispensible during early organogenesis. In adult mice both SETD1A and SETD1B regulate hematopoiesis differently: SETD1A is required for the establishment of definitive hematopoiesis whereas …
SETD1A is required shortly after epiblast formation whereas SETD1B becomes indispensible during early organogenesis. In adult mice bo …
Identification of genomic alterations in oesophageal squamous cell cancer.
Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q. Song Y, et al. Nature. 2014 May 1;509(7498):91-5. doi: 10.1038/nature13176. Epub 2014 Mar 16. Nature. 2014. PMID: 24670651
Oesophageal cancer is one of the most aggressive cancers and is the sixth leading cause of cancer death worldwide. Approximately 70% of global oesophageal cancer cases occur in China, with oesophageal squamous cell carcinoma (ESCC) being the histopatho …
Oesophageal cancer is one of the most aggressive cancers and is the sixth leading cause of cancer death worldwide. Appr …
SETD1B-associated neurodevelopmental disorder.
Roston A, Evans D, Gill H, McKinnon M, Isidor B, Cogné B, Mwenifumbo J, van Karnebeek C, An J, Jones SJM, Farrer M, Demos M, Connolly M, Gibson WT; CAUSES Study; EPGEN Study. Roston A, et al. J Med Genet. 2021 Mar;58(3):196-204. doi: 10.1136/jmedgenet-2019-106756. Epub 2020 Jun 16. J Med Genet. 2021. PMID: 32546566
BACKGROUND: Dysfunction of histone methyltransferases and chromatin modifiers has been implicated in complex neurodevelopmental syndromes and cancers. SETD1B encodes a lysine-specific methyltransferase that assists in transcriptional activation of genes by depositin …
BACKGROUND: Dysfunction of histone methyltransferases and chromatin modifiers has been implicated in complex neurodevelopmental syndromes an …
Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia.
Cheon H, Xing JC, Moosic KB, Ung J, Chan VW, Chung DS, Toro MF, Elghawy O, Wang JS, Hamele CE, Hardison RC, Olson TL, Tan SF, Feith DJ, Ratan A, Loughran TP. Cheon H, et al. Blood. 2022 May 19;139(20):3058-3072. doi: 10.1182/blood.2021013164. Blood. 2022. PMID: 35015834 Free PMC article.
Moreover, STAT3 mutations co-occurred with mutations in chromatin and epigenetic modifying genes, especially KMT2D and SETD1B (P < .01 and P < .05, respectively). STAT3 was mutated in 50.5% of the patients. ...
Moreover, STAT3 mutations co-occurred with mutations in chromatin and epigenetic modifying genes, especially KMT2D and SETD1B (P < …
High-level SETD1B gene expression is associated with unfavorable prognosis in hepatocellular carcinoma.
Chen D, Li T, Wang C, Lei G, Wang R, Wang Z, Yu L, Yan J, Zhang P, Wang X, Zhang S, Yang P. Chen D, et al. Mol Med Rep. 2019 Mar;19(3):1587-1594. doi: 10.3892/mmr.2019.9832. Epub 2019 Jan 8. Mol Med Rep. 2019. PMID: 30628696 Free PMC article.
However, the role of SETD1B in hepatocellular carcinoma (HCC) is largely unexplored. The present study, examined the expression of SETD1B in patients with HCC and assessed its clinical significance. ...Patients with HCC with decreased levels of SETD1B express …
However, the role of SETD1B in hepatocellular carcinoma (HCC) is largely unexplored. The present study, examined the expression of …
SETD1B Activates iNOS Expression in Myeloid-Derived Suppressor Cells.
Redd PS, Ibrahim ML, Klement JD, Sharman SK, Paschall AV, Yang D, Nayak-Kapoor A, Liu K. Redd PS, et al. Cancer Res. 2017 Jun 1;77(11):2834-2843. doi: 10.1158/0008-5472.CAN-16-2238. Epub 2017 Apr 5. Cancer Res. 2017. PMID: 28381543 Free PMC article.
Chromatin immunoprecipitation revealed that H3K4me3, the target of SETD1B, was enriched at the nos2 promoter in tumor-induced MDSCs, and inhibition or silencing of SETD1B diminished iNOS expression in tumor-induced MDSCs. ...Cancer Res; 77(11); 2834-43. 2017 …
Chromatin immunoprecipitation revealed that H3K4me3, the target of SETD1B, was enriched at the nos2 promoter in tumor-induced MDSCs, …
EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells.
Lindner P, Paul S, Eckstein M, Hampel C, Muenzner JK, Erlenbach-Wuensch K, Ahmed HP, Mahadevan V, Brabletz T, Hartmann A, Vera J, Schneider-Stock R. Lindner P, et al. Cell Death Dis. 2020 Feb 24;11(2):147. doi: 10.1038/s41419-020-2340-4. Cell Death Dis. 2020. PMID: 32094334 Free PMC article.
In this study, in silico analysis was performed in combination with different in vitro and in vivo techniques to identify and verify novel epigenetic targets of ZEB1, and to proof the direct transcriptional regulation of SETD1B by ZEB1. The chorioallantoic-membrane assay s …
In this study, in silico analysis was performed in combination with different in vitro and in vivo techniques to identify and verify novel e …
The MLL/SET family and haematopoiesis.
Antunes ETB, Ottersbach K. Antunes ETB, et al. Biochim Biophys Acta Gene Regul Mech. 2020 Aug;1863(8):194579. doi: 10.1016/j.bbagrm.2020.194579. Epub 2020 May 7. Biochim Biophys Acta Gene Regul Mech. 2020. PMID: 32389825 Free PMC article. Review.
One of its members, MLL1, has additionally received a lot of attention as it is a potent oncogenic driver in different types of leukaemia when aberrantly fused to a large variety of partners as a result of chromosomal translocations. Its exclusive association with cancers …
One of its members, MLL1, has additionally received a lot of attention as it is a potent oncogenic driver in different types of leukaemia wh …
Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability.
Choi YJ, Oh HR, Choi MR, Gwak M, An CH, Chung YJ, Yoo NJ, Lee SH. Choi YJ, et al. Hum Pathol. 2014 Aug;45(8):1674-81. doi: 10.1016/j.humpath.2014.04.013. Epub 2014 Apr 24. Hum Pathol. 2014. PMID: 24925220
Histone methyltransferase (HMT), which catalyzes a histone methylation, is frequently altered in cancers at mutation and expression levels. The aims of this study were to explore whether SETD1B, SETDB2, and SETD2, SET domain-containing HMT genes, are mutated and exp …
Histone methyltransferase (HMT), which catalyzes a histone methylation, is frequently altered in cancers at mutation and expression l …
39 results