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SETDB1 in cancer: overexpression and its therapeutic implications.
Lazaro-Camp VJ, Salari K, Meng X, Yang S. Lazaro-Camp VJ, et al. Am J Cancer Res. 2021 May 15;11(5):1803-1827. eCollection 2021. Am J Cancer Res. 2021. PMID: 34094655 Free PMC article. Review.
The Cancer Cell Line Encyclopedia (CCLE) screened SETDB1 dependency in 796 cancer cell lines, identifying SETDB1 as a common essential gene in 531 of them, demonstrating that SETDB1 expression is critical for the survival of the majority of c …
The Cancer Cell Line Encyclopedia (CCLE) screened SETDB1 dependency in 796 cancer cell lines, identifying SETDB1 …
CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer.
Meng X, Xiao W, Sun J, Li W, Yuan H, Yu T, Zhang X, Dong W. Meng X, et al. Cancer Lett. 2023 Feb 1;554:216023. doi: 10.1016/j.canlet.2022.216023. Epub 2022 Nov 25. Cancer Lett. 2023. PMID: 36436682 Free article.
Bladder cancer (BCa), characterized by high invasion, metastasis, recurrence, and chemoresistance, is one of the most prevalent urologic malignant tumors. ...Mechanistically, circPTK2 could bind to PABPC1 and enhance its ability to stabilize SETDB1 mRNA, thereby spe …
Bladder cancer (BCa), characterized by high invasion, metastasis, recurrence, and chemoresistance, is one of the most prevalent urolo …
SETDB1: A perspective into immune cell function and cancer immunotherapy.
Johnson E, Salari K, Yang S. Johnson E, et al. Immunology. 2023 May;169(1):3-12. doi: 10.1111/imm.13619. Epub 2022 Dec 21. Immunology. 2023. PMID: 36524435 Free PMC article. Review.
SETDB1 immune functions include B cell maturation, T cell activity regulation, and immune escape in cancer cells. ...In this review, we further discuss the immunological mechanisms of SETDB1 in normal and cancerous cells and its implications in canc …
SETDB1 immune functions include B cell maturation, T cell activity regulation, and immune escape in cancer cells. ...In this r …
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi AG, Ishizuka JJ, Kim SY, Klaeger S, Knudsen NH, Miller BC, Nguyen TH, Olander KE, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary MD, Zimmer MD, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Manguso RT, Bernstein BE. Griffin GK, et al. Nature. 2021 Jul;595(7866):309-314. doi: 10.1038/s41586-021-03520-4. Epub 2021 May 5. Nature. 2021. PMID: 33953401 Free PMC article.
We identified the H3K9 methyltransferase SETDB1 and other members of the HUSH and KAP1 complexes as mediators of immune escape(3-5). ...SETDB1 represses broad domains, primarily within the open genome compartment. ...
We identified the H3K9 methyltransferase SETDB1 and other members of the HUSH and KAP1 complexes as mediators of immune escape(3-5). …
SETDB1 confers colorectal cancer metastasis by regulation of WNT/beta-catenin signaling.
Li W, Yang X, Liu X, Deng H, Li W, He X, Zhang W, Shen Y, Li X, Peng Q, Liu D. Li W, et al. Biochim Biophys Acta Gen Subj. 2023 Jul;1867(7):130377. doi: 10.1016/j.bbagen.2023.130377. Epub 2023 May 9. Biochim Biophys Acta Gen Subj. 2023. PMID: 37169209
Here, we explored a novel mechanism by which SETDB1 promotes tumor metastasis in colorectal cancer. METHODS: We conducted database and clinical specimen analysis to determine the expression level of SETDB1 in colorectal cancer, as well as the prognosis …
Here, we explored a novel mechanism by which SETDB1 promotes tumor metastasis in colorectal cancer. METHODS: We conducted data …
The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity.
Lin J, Guo D, Liu H, Zhou W, Wang C, Müller I, Kossenkov AV, Drapkin R, Bitler BG, Helin K, Zhang R. Lin J, et al. Cancer Immunol Res. 2021 Dec;9(12):1413-1424. doi: 10.1158/2326-6066.CIR-21-0754. Cancer Immunol Res. 2021. PMID: 34848497 Free PMC article.
Mechanistically, SETDB1-TRIM28 inhibition led to micronuclei formation in the cytoplasm, which is known to activate the cGAS-STING pathway. Thus, SETDB1-TRIM28 inhibition bridges innate and adaptive immunity. Indeed, SETDB1 knockout enhanced the antitumor eff …
Mechanistically, SETDB1-TRIM28 inhibition led to micronuclei formation in the cytoplasm, which is known to activate the cGAS-STING pa …
SETDB1 as a cancer target: challenges and perspectives in drug design.
Hassanie H, Penteado AB, de Almeida LC, Calil RL, da Silva Emery F, Costa-Lotufo LV, Trossini GHG. Hassanie H, et al. RSC Med Chem. 2024 Mar 19;15(5):1424-1451. doi: 10.1039/d3md00366c. eCollection 2024 May 22. RSC Med Chem. 2024. PMID: 38799223 Review.
For this reason, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) has gained a lot of attention recently as a cancer target. ...Thus, SETDB1 appears to be an attractive epigenetic target for new cancer treatments. ...
For this reason, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) has gained a lot of attention recently as a can …
The Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma.
Yuan L, Sun B, Xu L, Chen L, Ou W. Yuan L, et al. Int J Mol Sci. 2021 Jul 10;22(14):7416. doi: 10.3390/ijms22147416. Int J Mol Sci. 2021. PMID: 34299035 Free PMC article. Review.
SETDB1 complexes (SETDB1-KRAB-KAP1, SETDB1-DNMT3A, SETDB1-PML, SETDB1-ATF7IP-MBD1) play crucial roles in the processes of histone methylation, transcriptional suppression and chromatin remodelling. ...Lung cancer is the most common type o …
SETDB1 complexes (SETDB1-KRAB-KAP1, SETDB1-DNMT3A, SETDB1-PML, SETDB1-ATF7IP-MBD1) play crucial roles in …
The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy.
Micevic G, Bosenberg MW, Yan Q. Micevic G, et al. Clin Cancer Res. 2023 Apr 3;29(7):1173-1182. doi: 10.1158/1078-0432.CCR-22-0784. Clin Cancer Res. 2023. PMID: 36449280 Free PMC article. Review.
Certain "cold" tumor types, such as pancreatic cancer, exhibit very low response rates to ICI due to intrinsically low immunogenicity. ...Several recent studies show that epigenetic modifiers, such as SETDB1 and LSD1, can play critical roles in regulating both tumor …
Certain "cold" tumor types, such as pancreatic cancer, exhibit very low response rates to ICI due to intrinsically low immunogenicity …
SETDB1: Progress and prospects in cancer treatment potential and inhibitor research.
Ma T, Xu F, Hou Y, Shu Y, Zhao Z, Zhang Y, Bai L, Feng L, Zhong L. Ma T, et al. Bioorg Chem. 2024 Apr;145:107219. doi: 10.1016/j.bioorg.2024.107219. Epub 2024 Feb 17. Bioorg Chem. 2024. PMID: 38377821 Review.
To better facilitate the development of anti-tumor therapy targeting SETDB1, we have conducted a comprehensive review of SETDB1 in this account. We present the structure and function of SETDB1, its role in various tumors and immune regulation, as well as the …
To better facilitate the development of anti-tumor therapy targeting SETDB1, we have conducted a comprehensive review of SETDB1 …
245 results