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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1995 3
1996 4
1997 9
1998 5
1999 15
2000 11
2001 15
2002 20
2003 34
2004 50
2005 38
2006 76
2007 74
2008 77
2009 96
2010 97
2011 128
2012 167
2013 173
2014 205
2015 211
2016 203
2017 181
2018 216
2019 273
2020 264
2021 243
2022 224
2023 177
2024 65

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2,962 results

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Page 1
The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Skoda AM, Simovic D, Karin V, Kardum V, Vranic S, Serman L. Skoda AM, et al. Bosn J Basic Med Sci. 2018 Feb 20;18(1):8-20. doi: 10.17305/bjbms.2018.2756. Bosn J Basic Med Sci. 2018. PMID: 29274272 Free PMC article. Review.
Deregulation of the Hh signaling pathway is associated with developmental anomalies and cancer, including Gorlin syndrome, and sporadic cancers, such as basal cell carcinoma, medulloblastoma, pancreatic, breast, colon, ovarian, and small-cell lung carcinomas. ...Sev …
Deregulation of the Hh signaling pathway is associated with developmental anomalies and cancer, including Gorlin syndrome, and sporad …
Hedgehog signaling mechanism and role in cancer.
Jiang J. Jiang J. Semin Cancer Biol. 2022 Oct;85:107-122. doi: 10.1016/j.semcancer.2021.04.003. Epub 2021 Apr 6. Semin Cancer Biol. 2022. PMID: 33836254 Free PMC article. Review.
Deregulation of these signaling pathways has been implicated in a wide range of human diseases including cancer. One such pathway is the Hedgehog (Hh) pathway, which was originally discovered in Drosophila and later found to play a fundamental role in human development and …
Deregulation of these signaling pathways has been implicated in a wide range of human diseases including cancer. One such pathway is …
Role of Sonic Hedgehog (Shh) Signaling in Bladder Cancer Stemness and Tumorigenesis.
Syed IS, Pedram A, Farhat WA. Syed IS, et al. Curr Urol Rep. 2016 Feb;17(2):11. doi: 10.1007/s11934-015-0568-9. Curr Urol Rep. 2016. PMID: 26757905 Review.
Sonic hedgehog (Shh) signaling pathway has emerged as a critical component of bladder development, cancer initiation, and progression. While the role of Shh signaling in bladder development is well documented, its role in bladder cancer progression is …
Sonic hedgehog (Shh) signaling pathway has emerged as a critical component of bladder development, cancer initiation, and prog …
A highlight on Sonic hedgehog pathway.
Carballo GB, Honorato JR, de Lopes GPF, Spohr TCLSE. Carballo GB, et al. Cell Commun Signal. 2018 Mar 20;16(1):11. doi: 10.1186/s12964-018-0220-7. Cell Commun Signal. 2018. PMID: 29558958 Free PMC article. Review.
So, a better knowledge of Shh signaling pathway opens an avenue of possibilities for the treatment of not only for brain tumors but also for other types of cancers. In this review, we will also highlight some clinical trials that use the Shh pathway as a targ …
So, a better knowledge of Shh signaling pathway opens an avenue of possibilities for the treatment of not only for brain tumors but a …
Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis.
Fu B, Liu W, Zhu C, Li P, Wang L, Pan L, Li K, Cai P, Meng M, Wang Y, Zhang A, Tang W, An M. Fu B, et al. Int J Biol Sci. 2021 Jul 22;17(12):3104-3117. doi: 10.7150/ijbs.58916. eCollection 2021. Int J Biol Sci. 2021. PMID: 34421353 Free PMC article.
Circular RNAs (circRNAs) play critical roles in tumorigenesis and the progression of various cancers. We previously identified a novel upregulated circRNA, circBCBM1 (hsa_circ_0001944), in the context of breast cancer brain metastasis. ...Mechanistically, circBCBM1 …
Circular RNAs (circRNAs) play critical roles in tumorigenesis and the progression of various cancers. We previously identified a nove …
Interaction of sonic hedgehog (SHH) pathway with cancer stem cell genes in gastric cancer.
Samadani AA, Akhavan-Niaki H. Samadani AA, et al. Med Oncol. 2015 Mar;32(3):48. doi: 10.1007/s12032-015-0492-3. Epub 2015 Jan 31. Med Oncol. 2015. PMID: 25636508 Review.
Molecular studies show the possibility of involvement of certain cancer pathways in gastric cancer. In this respect, DNA methylation is one of the most important epigenetic alterations in gastric cancer and identifying the signaling mechanism and also methyla …
Molecular studies show the possibility of involvement of certain cancer pathways in gastric cancer. In this respect, DNA methy …
The Role of EREG/EGFR Pathway in Tumor Progression.
Cheng WL, Feng PH, Lee KY, Chen KY, Sun WL, Van Hiep N, Luo CS, Wu SM. Cheng WL, et al. Int J Mol Sci. 2021 Nov 27;22(23):12828. doi: 10.3390/ijms222312828. Int J Mol Sci. 2021. PMID: 34884633 Free PMC article. Review.
Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor malignancies, including lung cancer and colorectal cancer (CRC). Epiregulin (EREG) is one of the EG …
Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic leukemia viral oncogene homolog (ERBB) ligands co …
Silencing GS Homeobox 2 Alleviates Gemcitabine Resistance in Pancreatic Cancer Cells by Activating SHH/GLI1 Signaling Pathway.
Zhuang L, Yao Y, Peng L, Cui F, Chen C, Zhang Y, Sun L, Yu Q, Lin K. Zhuang L, et al. Dig Dis Sci. 2022 Aug;67(8):3773-3782. doi: 10.1007/s10620-021-07262-1. Epub 2021 Oct 8. Dig Dis Sci. 2022. PMID: 34623580
It was found that GSH2 is overexpressed in human pancreatic cancer tissues and cells. The expression of SHH and GLI1 was reversely correlated with GSH2 in pancreatic cancer cells. ...Our results indicate that GSH2 is overexpressed in pancreatic cancer. …
It was found that GSH2 is overexpressed in human pancreatic cancer tissues and cells. The expression of SHH and GLI1 was rever …
SHH Expression Is Significantly Associated With Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma.
Cierpikowski P, Lis-Nawara A, Bar J. Cierpikowski P, et al. Anticancer Res. 2021 Nov;41(11):5405-5413. doi: 10.21873/anticanres.15352. Anticancer Res. 2021. PMID: 34732409
BACKGROUND/AIM: Oral squamous cell carcinoma (OSCC) is a highly invasive malignancy with poor prognosis. Recent reports suggest that Sonic Hedgehog (SHH) plays a key role in tumor progression and worsens the response to therapy, possibly through an association with a ca …
BACKGROUND/AIM: Oral squamous cell carcinoma (OSCC) is a highly invasive malignancy with poor prognosis. Recent reports suggest that Sonic H …
2,962 results