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Page 1
Integrative genomic profiling of human prostate cancer.
Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL. Taylor BS, et al. Cancer Cell. 2010 Jul 13;18(1):11-22. doi: 10.1016/j.ccr.2010.05.026. Epub 2010 Jun 24. Cancer Cell. 2010. PMID: 20579941 Free PMC article.
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuc …
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Conc …
SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response.
Liu H, Xie S, Fang F, Kalvakolanu DV, Xiao W. Liu H, et al. Cell Death Dis. 2020 Jun 10;11(6):445. doi: 10.1038/s41419-020-2656-0. Cell Death Dis. 2020. PMID: 32522979 Free PMC article.
It was independently isolated as a growth suppressor, GRIM1, in a genetic screen. Recent studies have indicated that SHQ1 inhibits prostate cancer growth and metastasis. SHQ1 facilitates MYC RNA splicing to promote T-acute lymphoblastic leukemia (T-ALL) devel …
It was independently isolated as a growth suppressor, GRIM1, in a genetic screen. Recent studies have indicated that SHQ1 inhibits pr …
beta-Sitosterol attenuates anlotinib resistance in non-small cell lung cancer cells by inhibiting miR-181a-3p/SHQ1 signaling.
Wang LH, Sun YH, Liu H, Yang X, Wen Z, Tian XF. Wang LH, et al. Chem Biol Drug Des. 2024 Mar;103(3):e14493. doi: 10.1111/cbdd.14493. Chem Biol Drug Des. 2024. PMID: 38439529
Anlotinib is used for the treatment of advanced non-small cell lung cancer; however, the emergence of drug resistance limits its clinical application. beta-sitosterol may also be used to treat lung cancer, but there have been no studies evaluating beta-sitosterol ag …
Anlotinib is used for the treatment of advanced non-small cell lung cancer; however, the emergence of drug resistance limits its clin …
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.
Su H, Hu J, Huang L, Yang Y, Thenoz M, Kuchmiy A, Hu Y, Li P, Feng H, Zhou Y, Taghon T, Van Vlierberghe P, Qing G, Chen Z, Liu H. Su H, et al. Nat Commun. 2018 Oct 15;9(1):4281. doi: 10.1038/s41467-018-06523-4. Nat Commun. 2018. PMID: 30323192 Free PMC article.
Mechanistically, oncogenic NOTCH1 directly binds to the SHQ1 promoter and activates its transcription. SHQ1 depletion induces T-ALL cell death in vitro and prolongs animal survival in murine T-ALL models. ...MYC overexpression significantly rescues T-ALL cell death …
Mechanistically, oncogenic NOTCH1 directly binds to the SHQ1 promoter and activates its transcription. SHQ1 depletion induces …
Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis.
Hieronymus H, Iaquinta PJ, Wongvipat J, Gopalan A, Murali R, Mao N, Carver BS, Sawyers CL. Hieronymus H, et al. Nat Commun. 2017 Oct 20;8(1):1081. doi: 10.1038/s41467-017-01198-9. Nat Commun. 2017. PMID: 29057879 Free PMC article.
A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is commonly deleted in prostate cancer and lost broadly in a range of cancers but has unknown significance to oncogenesis or prognosis. ...Moreover, FOXP1-SHQ1 deletion has prognostic relevance, wi …
A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is commonly deleted in prostate cancer and lost broadly in a range of …
Biallelic SHQ1 variants in early infantile hypotonia and paroxysmal dystonia as the leading manifestation.
Chi CS, Tsai CR, Lee HF. Chi CS, et al. Hum Genet. 2023 Aug;142(8):1029-1041. doi: 10.1007/s00439-023-02533-5. Epub 2023 Feb 27. Hum Genet. 2023. PMID: 36847845
Biallelic SHQ1 variant-related neurodevelopmental disorder is extremely rare. ...The four novel SHQ1 variants transfected into human SH-SY5Y neuronal cells resulted in a retardation in neuronal migration, suggestive of SHQ1 variant correlated with neurodevelo …
Biallelic SHQ1 variant-related neurodevelopmental disorder is extremely rare. ...The four novel SHQ1 variants transfected into …
Structure and interactions of the CS domain of human H/ACA RNP assembly protein Shq1.
Singh M, Wang Z, Cascio D, Feigon J. Singh M, et al. J Mol Biol. 2015 Feb 27;427(4):807-823. doi: 10.1016/j.jmb.2014.12.012. Epub 2014 Dec 29. J Mol Biol. 2015. PMID: 25553844 Free PMC article.
Shq1 contains an N-terminal CS and a C-terminal Shq1-specific domain (SSD). ...Here, we present the crystal structure of human Shq1 CS (hCS) and the nuclear magnetic resonance (NMR) and crystal structures of hCS containing a serine substitution for proline 22 …
Shq1 contains an N-terminal CS and a C-terminal Shq1-specific domain (SSD). ...Here, we present the crystal structure of human …
RNA-guided isomerization of uridine to pseudouridine--pseudouridylation.
Yu YT, Meier UT. Yu YT, et al. RNA Biol. 2014;11(12):1483-94. doi: 10.4161/15476286.2014.972855. RNA Biol. 2014. PMID: 25590339 Free PMC article. Review.
Finally, we consider possible mechanisms of the bone marrow failure syndrome dyskeratosis congenita and of prostate and other cancers linked to mutations in H/ACA RNPs....
Finally, we consider possible mechanisms of the bone marrow failure syndrome dyskeratosis congenita and of prostate and other cancers …
Regulation of snoRNAs in cancer: close encounters with interferon.
Nallar SC, Kalvakolanu DV. Nallar SC, et al. J Interferon Cytokine Res. 2013 Apr;33(4):189-98. doi: 10.1089/jir.2012.0106. J Interferon Cytokine Res. 2013. PMID: 23570385 Free PMC article. Review.
Our laboratory recently isolated a growth-suppressive protein gene associated with retinoid-IFN-induced mortality (GRIM)-1 using a genetic screen. IFN-inducible GRIM-1 (SHQ1) is an assembly factor that controls one arm of the snoRNP machinery. GRIM-1 inhibits sno/scaRNP fo …
Our laboratory recently isolated a growth-suppressive protein gene associated with retinoid-IFN-induced mortality (GRIM)-1 using a genetic s …
Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.
Ulz P, Belic J, Graf R, Auer M, Lafer I, Fischereder K, Webersinke G, Pummer K, Augustin H, Pichler M, Hoefler G, Bauernhofer T, Geigl JB, Heitzer E, Speicher MR. Ulz P, et al. Nat Commun. 2016 Jun 22;7:12008. doi: 10.1038/ncomms12008. Nat Commun. 2016. PMID: 27328849 Free PMC article.
Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here we analyse 493 prostate cancer cases from the TCGA database and perform whole-genome plasma sequencing on 95 plasma samples derived from 43 patients with metastatic prostate …
Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here we analyse 493 prostate cancer cases …
16 results