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Page 1
Associations of genetic polymorphisms of Siglecs with human diseases.
Angata T. Angata T. Glycobiology. 2014 Sep;24(9):785-93. doi: 10.1093/glycob/cwu043. Epub 2014 May 19. Glycobiology. 2014. PMID: 24841380 Review.
Leading examples, such as the CD33 polymorphism associated with late-onset Alzheimer's disease, are well supported by genetic replication and mechanistic studies, while some others (such as SIGLEC8 polymorphism associated with bronchial asthma and SIGLEC14 polymorphism ass …
Leading examples, such as the CD33 polymorphism associated with late-onset Alzheimer's disease, are well supported by genetic replication an …
First Evidence for a Role of Siglec-8 in Breast Cancer.
Trebo A, Ditsch N, Degenhardt T, Kuhn C, Rahmeh M, Schmoeckel E, Mayr D, Czogalla B, Kolben T, Meister S, Mahner S, Jeschke U, Hester A. Trebo A, et al. Int J Mol Sci. 2021 Feb 18;22(4):2000. doi: 10.3390/ijms22042000. Int J Mol Sci. 2021. PMID: 33670444 Free PMC article.
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are involved in various immune cell-mediated diseases. Their role in cancer is poorly investigated, and research focusses on Siglec-expression on immune cells interacting with tumor cells. This study evaluates the r …
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are involved in various immune cell-mediated diseases. Their role in cancer …
Human CD79b+ neutrophils in the blood are associated with early-stage melanoma.
Meyer MA, Dinh HQ, Alimadadi A, Araujo DJ, Chatterjee N, Gutierrez NA, Zhu YP, Hunter EL, Liang S, Seumois G, Kiosses WB, Catz SD, Vijayanand P, Ottensmeier C, Hedrick CC. Meyer MA, et al. Front Immunol. 2023 Oct 31;14:1224045. doi: 10.3389/fimmu.2023.1224045. eCollection 2023. Front Immunol. 2023. PMID: 38022639 Free PMC article.
RESULTS: We identified CD79b(+) neutrophils (CD3(-)CD56(-)CD19(-)Siglec8(-)CD203c(-)CD86(Lo)CD66b(+)CD79b(+)) that are normally restricted to the bone marrow in healthy humans but appear in the blood of subjects with early-stage melanoma. Further, we found CD79b(+) neutrop …
RESULTS: We identified CD79b(+) neutrophils (CD3(-)CD56(-)CD19(-)Siglec8(-)CD203c(-)CD86(Lo)CD66b(+)CD79b(+)) that are normally restr …
18 results