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Year Number of Results
1996 2
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2002 5
2003 8
2004 6
2005 8
2006 7
2007 6
2008 7
2009 5
2010 7
2011 7
2012 9
2013 13
2014 12
2015 6
2016 12
2017 8
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2020 12
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225 results

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Page 1
Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis.
Davenport ML, Davis MR, Davenport BN, Crossman DK, Hall A, Pike J, Harada S, Hurst DR, Edmonds MD. Davenport ML, et al. Mol Cancer Res. 2022 Jun 3;20(6):883-894. doi: 10.1158/1541-7786.MCR-21-0508. Mol Cancer Res. 2022. PMID: 35247910 Free PMC article.
Patients with breast cancer with high levels of miR-183 and low levels of SIN3A have the shortest overall survival. ...IMPLICATIONS: SIN3A expression is decreased in metastatic breast cancer in part due to miR-183....
Patients with breast cancer with high levels of miR-183 and low levels of SIN3A have the shortest overall survival. ...IMPLICA …
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H. Chang S, et al. Exp Mol Med. 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. Exp Mol Med. 2019. PMID: 31221981 Free PMC article. Review.
Recent studies on mutations in cancer genomes have distinguished driver mutations from passenger mutations, which occur as byproducts of cancer development. The cancer genome atlas (TCGA) project identified 299 genes and 24 pathways/biological processes that …
Recent studies on mutations in cancer genomes have distinguished driver mutations from passenger mutations, which occur as byproducts …
SIN3A and SIN3B differentially regulate breast cancer metastasis.
Lewis MJ, Liu J, Libby EF, Lee M, Crawford NP, Hurst DR. Lewis MJ, et al. Oncotarget. 2016 Nov 29;7(48):78713-78725. doi: 10.18632/oncotarget.12805. Oncotarget. 2016. PMID: 27780928 Free PMC article.
However, specific roles for SIN3A and SIN3B in breast cancer progression have not been characterized. ...Additionally, we analyzed microarray data sets to identify correlations of SIN3A and SIN3B expression with survival in patients with breast cancer. …
However, specific roles for SIN3A and SIN3B in breast cancer progression have not been characterized. ...Additionally, we anal …
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding.
Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Aceto N. Gkountela S, et al. Cell. 2019 Jan 10;176(1-2):98-112.e14. doi: 10.1016/j.cell.2018.11.046. Cell. 2019. PMID: 30633912 Free PMC article.
Here, we profile the DNA methylation landscape of single CTCs and CTC clusters from breast cancer patients and mouse models on a genome-wide scale. We find that binding sites for stemness- and proliferation-associated transcription factors are specifically hypomethylated i …
Here, we profile the DNA methylation landscape of single CTCs and CTC clusters from breast cancer patients and mouse models on a geno …
Nuclear complement C3b promotes paclitaxel resistance by assembling the SIN3A/HDAC1/2 complex in non-small cell lung cancer.
Wang X, Hao Y, Chen J, Ding P, Lv X, Zhou D, Li L, Li L, Xu Y, Zhu Y, Zhang W, Chen L, Liao T, He X, Ji QH, Hu W. Wang X, et al. Cell Death Dis. 2023 Jun 8;14(6):351. doi: 10.1038/s41419-023-05869-y. Cell Death Dis. 2023. PMID: 37291119 Free PMC article.
Here, we revealed that complement component 3 (C3) is remarkably upregulated in paclitaxel (PTX)-resistant non-small cell lung cancer (NSCLC) cells and that knockdown of C3 promoted PTX-induced cell apoptosis, sensitizing resistant cells to PTX therapy. ...Importantly, C3 …
Here, we revealed that complement component 3 (C3) is remarkably upregulated in paclitaxel (PTX)-resistant non-small cell lung cancer …
LINC00665 up-regulates SIN3A expression to modulate the progression of colorectal cancer via sponging miR-138-5p.
Nan S, Zhang S, Jin R, Wang J. Nan S, et al. Cancer Cell Int. 2022 Jan 31;22(1):51. doi: 10.1186/s12935-021-02176-4. Cancer Cell Int. 2022. PMID: 35101035 Free PMC article.
BACKGROUND: Colorectal cancer (CRC) is a malignant tumor affecting people worldwide. Long noncoding RNAs (lncRNAs) is a crucial factor modulating various cancer progression, including CRC. ...CONCLUSIONS: LINC00665 could sponge miR-138-5p to up-regulate SIN3A …
BACKGROUND: Colorectal cancer (CRC) is a malignant tumor affecting people worldwide. Long noncoding RNAs (lncRNAs) is a crucial facto …
The regulation and function of CD20: an "enigma" of B-cell biology and targeted therapy.
Pavlasova G, Mraz M. Pavlasova G, et al. Haematologica. 2020 Jun;105(6):1494-1506. doi: 10.3324/haematol.2019.243543. Haematologica. 2020. PMID: 32482755 Free PMC article. Review.
Furthermore, CD20 expression is highly variable between different B-cell malignancies, patients with the same malignancy, and even between intraclonal subpopulations in an individual patient. Several epigenetic (EZH2, HDAC1/2, HDAC1/4, HDAC6, complex Sin3A-HDAC1) and trans …
Furthermore, CD20 expression is highly variable between different B-cell malignancies, patients with the same malignancy, and even between i …
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.
Hu CL, Chen BY, Li Z, Yang T, Xu CH, Yang R, Yu PC, Zhao J, Liu T, Liu N, Shan B, Zhang Q, Song J, Fei MY, Zong LJ, Zhang JY, Wu JC, Chen SB, Wang Y, Chang B, Hou D, Liu P, Jiang Y, Li X, Chen X, Deng CH, Ren YY, Wang R, Jin J, Xue K, Zhang Y, Du M, Shi J, Wu LY, Chang CK, Shen S, Chen Z, Chen SJ, Liu X, Sun XJ, Zheng M, Wang L. Hu CL, et al. Cell Res. 2022 Dec;32(12):1105-1123. doi: 10.1038/s41422-022-00735-6. Epub 2022 Oct 27. Cell Res. 2022. PMID: 36302855 Free PMC article.
UHRF1 is required for myeloid leukemogenesis by maintaining self-renewal of LICs. Mechanistically, UHRF1 directly interacts with Sin3A-associated protein 30 (SAP30) through two critical amino acids, G572 and F573 in its SRA domain, to repress gene expression. ...
UHRF1 is required for myeloid leukemogenesis by maintaining self-renewal of LICs. Mechanistically, UHRF1 directly interacts with Sin3A …
The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer.
Li W, Zhang Z, Liu X, Cheng X, Zhang Y, Han X, Zhang Y, Liu S, Yang J, Xu B, He L, Sun L, Liang J, Shang Y. Li W, et al. J Clin Invest. 2017 Sep 1;127(9):3421-3440. doi: 10.1172/JCI94233. Epub 2017 Aug 14. J Clin Invest. 2017. PMID: 28805661 Free PMC article.
We demonstrated that the FOXN3-NEAT1-SIN3A complex promotes EMT and invasion of breast cancer cells in vitro as well as dissemination and metastasis of breast cancer in vivo. ...Further, our study identified the ERalpha-NEAT1-FOXN3/NEAT1/SIN3A-GATA3 ax …
We demonstrated that the FOXN3-NEAT1-SIN3A complex promotes EMT and invasion of breast cancer cells in vitro as well as dissem …
Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor.
Ellison-Zelski SJ, Alarid ET. Ellison-Zelski SJ, et al. Mol Cancer. 2010 Sep 29;9:263. doi: 10.1186/1476-4598-9-263. Mol Cancer. 2010. PMID: 20920219 Free PMC article.
Here, we expand our previous studies to elucidate the function of Sin3A in the control of gene expression and growth of breast cancer cells. ...Loss of Sin3A inhibited breast cancer cell growth by increasing apoptosis without affecting cell cycle progr …
Here, we expand our previous studies to elucidate the function of Sin3A in the control of gene expression and growth of breast can …
225 results