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81 results

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Six2 promotes non-small cell lung cancer cell stemness via transcriptionally and epigenetically regulating E-cadherin.
Hou H, Yu X, Cong P, Zhou Y, Xu Y, Jiang Y. Hou H, et al. Cell Prolif. 2019 Jul;52(4):e12617. doi: 10.1111/cpr.12617. Epub 2019 Apr 22. Cell Prolif. 2019. PMID: 31012173 Free PMC article. Retracted.
OBJECTIVES: The roles and related mechanisms of six2 in regulating non-small cell lung cancer (NSCLC) cells progression are unclear. ...Six2 expression was higher in lung cancer tissues than in normal adjacent tissues. ...
OBJECTIVES: The roles and related mechanisms of six2 in regulating non-small cell lung cancer (NSCLC) cells progression are un …
SIX2 promotes cell plasticity via Wnt/beta-catenin signalling in androgen receptor independent prostate cancer.
Leppänen N, Kaljunen H, Takala E, Kaarijärvi R, Mäkinen PI, Ylä-Herttuala S, Paatero I, Paakinaho V, Ketola K. Leppänen N, et al. Nucleic Acids Res. 2024 Mar 30:gkae206. doi: 10.1093/nar/gkae206. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38554106
Depletion of SIX2 in androgen-independent PC-3 prostate cancer cells induced a switch from a stem-like to an epithelial state, resulting in reduced cancer-related properties such as proliferation, colony formation, and metastasis both in vitro and in vivo. .. …
Depletion of SIX2 in androgen-independent PC-3 prostate cancer cells induced a switch from a stem-like to an epithelial state, …
Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression.
Wang CA, Drasin D, Pham C, Jedlicka P, Zaberezhnyy V, Guney M, Li H, Nemenoff R, Costello JC, Tan AC, Ford HL. Wang CA, et al. Cancer Res. 2014 Dec 15;74(24):7357-70. doi: 10.1158/0008-5472.CAN-14-0666. Epub 2014 Oct 27. Cancer Res. 2014. PMID: 25348955 Free PMC article.
In this study, we report the involvement of the kidney development transcription factor Six2 in the metastatic progression of human breast cancer. We found that Six2 promoted breast cancer metastasis by a novel mechanism involving both transcriptional …
In this study, we report the involvement of the kidney development transcription factor Six2 in the metastatic progression of human b …
Identification and Characterization of the Wilms Tumor Cancer Stem Cell.
Petrosyan A, Villani V, Aguiari P, Thornton ME, Wang Y, Rajewski A, Zhou S, Cravedi P, Grubbs BH, De Filippo RE, Sedrakyan S, Lemley KV, Csete M, Da Sacco S, Perin L. Petrosyan A, et al. Adv Sci (Weinh). 2023 Jul;10(20):e2206787. doi: 10.1002/advs.202206787. Epub 2023 Apr 28. Adv Sci (Weinh). 2023. PMID: 37114795 Free PMC article.
NP from WT samples with NP from the developing human kidney is compared. Cells expressing SIX2 and CITED1 fulfill cancer stem cell criteria by reliably recapitulating WT in transplantation studies. ...These studies define SIX2+CITED1+ cells as the nephrogenic …
NP from WT samples with NP from the developing human kidney is compared. Cells expressing SIX2 and CITED1 fulfill cancer stem …
Circular RNA 0007255 regulates the progression of breast cancer through miR-335-5p/SIX2 axis.
Jia Q, Ye L, Xu S, Xiao H, Xu S, Shi Z, Li J, Chen Z. Jia Q, et al. Thorac Cancer. 2020 Mar;11(3):619-630. doi: 10.1111/1759-7714.13306. Epub 2020 Jan 21. Thorac Cancer. 2020. PMID: 31962380 Free PMC article.
BACKGROUND: Breast cancer (BC) is a common cancer in women worldwide. Emerging evidence has indicated that circular RNA hsa-circ_0007255 (circ_0007255) is a prognostic mediator in BC progression. ...RESULTS: Circ_0007255 and SIX2 were overexpressed, but miR-3 …
BACKGROUND: Breast cancer (BC) is a common cancer in women worldwide. Emerging evidence has indicated that circular RNA hsa-ci …
Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.
Zheng L, Guo Q, Xiang C, Liu S, Jiang Y, Gao L, Ni H, Wang T, Zhao Q, Liu H, Xing Y, Wang Y, Li X, Xi T. Zheng L, et al. J Hematol Oncol. 2019 Mar 4;12(1):23. doi: 10.1186/s13045-019-0697-6. J Hematol Oncol. 2019. PMID: 30832689 Free PMC article.
METHODS: Transcriptional factor six2, CYP4Z1-3'UTR, and CYP4Z2P-3'UTR were stably overexpressed or knocked down in breast cancer cells via lentivirus infection. ...Finally, we demonstrated that the six2/ceRNET_CC axis was involved in chemoresistance. CONCLUSI …
METHODS: Transcriptional factor six2, CYP4Z1-3'UTR, and CYP4Z2P-3'UTR were stably overexpressed or knocked down in breast cancer …
SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program.
Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL. Oliphant MUJ, et al. Cancer Res. 2019 Feb 15;79(4):720-734. doi: 10.1158/0008-5472.CAN-18-1791. Epub 2019 Jan 3. Cancer Res. 2019. PMID: 30606720 Free PMC article.
Regulation of Sox2 by Six2 enhanced cancer stem cell properties and increased metastatic colonization. Six2 and Sox2 expression correlated highly in breast cancers including TNBC, where a Six2 expression signature was predictive of metastatic bu …
Regulation of Sox2 by Six2 enhanced cancer stem cell properties and increased metastatic colonization. Six2 and Sox2 ex …
RETRACTION: Six2 Promotes Non-Small Cell Lung Cancer Cell Stemness Via Transcriptionally and Epigenetically Regulating E-Cadherin.
[No authors listed] [No authors listed] Cell Prolif. 2024 May 28:e13682. doi: 10.1111/cpr.13682. Online ahead of print. Cell Prolif. 2024. PMID: 38804816
H. Hou, X. Yu, P. Cong, Y. Zhou, Y. Xu, Y. Jiang, "Six2 Promotes Non-Small Cell Lung Cancer Cell Stemness Via Transcriptionally and Epigenetically Regulating E-Cadherin," Cell Proliferation 52, no. 4 (2019): e12617, https://doi.org/10.1111/cpr.12617 The above articl …
H. Hou, X. Yu, P. Cong, Y. Zhou, Y. Xu, Y. Jiang, "Six2 Promotes Non-Small Cell Lung Cancer Cell Stemness Via Transcriptionall …
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
Gadd S, Huff V, Walz AL, Ooms AHAG, Armstrong AE, Gerhard DS, Smith MA, Auvil JMG, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Hermida LC, Davidsen T, Gesuwan P, Ma Y, Zong Z, Mungall AJ, Moore RA, Marra MA, Dome JS, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Ross N, Gastier-Foster JM, Arold ST, Perlman EJ. Gadd S, et al. Nat Genet. 2017 Oct;49(10):1487-1494. doi: 10.1038/ng.3940. Epub 2017 Aug 21. Nat Genet. 2017. PMID: 28825729 Free PMC article.
In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), we identified mutations in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR …
In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, …
Six2 is negatively correlated with prognosis and facilitates epithelial-mesenchymal transition via TGF-beta/Smad signal pathway in hepatocellular carcinoma.
Wan ZH, Ma YH, Jiang TY, Lin YK, Shi YY, Tan YX, Dong LW, Wang HY. Wan ZH, et al. Hepatobiliary Pancreat Dis Int. 2019 Dec;18(6):525-531. doi: 10.1016/j.hbpd.2019.09.005. Epub 2019 Sep 14. Hepatobiliary Pancreat Dis Int. 2019. PMID: 31564506
This study aimed to determine the role of Six2 in HCC and to elucidate the association of Six2 with clinical pathological characteristics. ...Six2 was highly expressed in PVTT. Six2 knockdown inhibited HCC cell lines proliferation, migration, and self- …
This study aimed to determine the role of Six2 in HCC and to elucidate the association of Six2 with clinical pathological char …
81 results