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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 2
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2002 1
2003 3
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2007 2
2008 7
2009 2
2010 2
2011 6
2012 9
2013 11
2014 8
2015 10
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2023 5
2024 4

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109 results

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[Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer].
Zhang YY, Cao J, Chen XT, Chen JH, Zheng YB. Zhang YY, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021 Jun 30;43(3):371-381. doi: 10.3881/j.issn.1000-503X.13096. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021. PMID: 34238413 Chinese.
Objective To explore the function and mechanism of related genes in the occurrence and development of liver cancer, and the possibility of key genes as potential biomarkers and prognostic indicators for the treatment of liver cancer.Methods We selected 4 datasets(GS …
Objective To explore the function and mechanism of related genes in the occurrence and development of liver cancer, and the possibili …
Emerging roles of metal solute carriers in cancer mechanisms and treatment.
Jong NN, McKeage MJ. Jong NN, et al. Biopharm Drug Dispos. 2014 Nov;35(8):450-62. doi: 10.1002/bdd.1903. Epub 2014 Sep 5. Biopharm Drug Dispos. 2014. PMID: 24889085 Review.
The literature concerning the roles of metal transporting solute carriers in the development and progression of human cancer, and in the delivery of metal-containing anticancer drugs, chemical carcinogens and imaging agents, is reviewed. A range of different solute carrier …
The literature concerning the roles of metal transporting solute carriers in the development and progression of human cancer, and in …
The Role of SLC22A1 and Genomic Ancestry on Toxicity during Treatment in Children with Acute Lymphoblastic Leukemia of the Amazon Region.
Fernandes SSM, Leitão LPC, Cohen-Paes AN, Gellen LPA, Pastana LF, de Carvalho DC, Modesto AAC, da Costa ACA, Wanderley AV, Lima CHV, Pereira EEB, Fernandes MR, Burbano RMR, de Assumpção PP, Santos SEBD, Santos NPCD. Fernandes SSM, et al. Genes (Basel). 2022 Mar 29;13(4):610. doi: 10.3390/genes13040610. Genes (Basel). 2022. PMID: 35456416 Free PMC article.
In Brazil, Acute lymphoid leukemia (ALL) is the leading cause of cancer deaths in children and adolescents. Treatment toxicity is one of the reasons for stopping chemotherapy. Amerindian genomic ancestry is an important factor for this event due to fluctuations in frequenc …
In Brazil, Acute lymphoid leukemia (ALL) is the leading cause of cancer deaths in children and adolescents. Treatment toxicity is one …
Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1.
Chen M, Neul C, Schaeffeler E, Frisch F, Winter S, Schwab M, Koepsell H, Hu S, Laufer S, Baker SD, Sparreboom A, Nies AT. Chen M, et al. Clin Pharmacol Ther. 2020 Jan;107(1):227-237. doi: 10.1002/cpt.1588. Epub 2019 Sep 3. Clin Pharmacol Ther. 2020. PMID: 31350763 Free PMC article.
Overexpression of functional OCT1 protein in Xenopus laevis oocytes and mammalian cell lines did not facilitate sorafenib transport. Otherwise, sorafenib considerably accumulated in liver cancer cell lines despite negligible OCT1 mRNA and protein levels. Sorafenib pharmaco …
Overexpression of functional OCT1 protein in Xenopus laevis oocytes and mammalian cell lines did not facilitate sorafenib transport. Otherwi …
Association of SLC22A1,SLCO1B3 Drug Transporter Polymorphisms and Smoking with Disease Risk and Cytogenetic Response to Imatinib in Patients with Chronic Myeloid Leukemia.
Mohammadi F, Rostami G, Assad D, Shafiei M, Hamid M, Jalaeikhoo H. Mohammadi F, et al. Lab Med. 2021 Nov 2;52(6):584-596. doi: 10.1093/labmed/lmab023. Lab Med. 2021. PMID: 34128532
OBJECTIVE: To determine whether polymorphisms of SLC22A1 and SLCO1B3 genes could predict imatinib (IM) response and chronic myeloid leukemia (CML) risk. METHODS: We genotyped SLC22A1 (c.480G > C, c.1222A > G) and SLCO1B3 (c.334T > G, c.699G > A) polymorp …
OBJECTIVE: To determine whether polymorphisms of SLC22A1 and SLCO1B3 genes could predict imatinib (IM) response and chronic myeloid l …
Imatinib Affects the Expression of SLC22A1 in a Non-Linear Concentration-Dependent Manner Within 24 Hours.
Sreenivasan Tantuan S, Viljoen CD. Sreenivasan Tantuan S, et al. Med Sci Monit Basic Res. 2018 Mar 23;24:59-62. doi: 10.12659/msmbr.909124. Med Sci Monit Basic Res. 2018. PMID: 29567937 Free PMC article.
BACKGROUND Imatinib is actively transported into cells by the organic cation transporter (OCT1), encoded by SLC22A1. As a result, the expression of SLC22A1 is considered a prognostic marker for treatment with imatinib in patients with chronic myeloid leukemia (CML). …
BACKGROUND Imatinib is actively transported into cells by the organic cation transporter (OCT1), encoded by SLC22A1. As a result, the …
Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).
Jonker JW, Schinkel AH. Jonker JW, et al. J Pharmacol Exp Ther. 2004 Jan;308(1):2-9. doi: 10.1124/jpet.103.053298. Epub 2003 Oct 23. J Pharmacol Exp Ther. 2004. PMID: 14576340 Review.
The polyspecific organic cation transporters OCT1, 2, and 3 (SLC22A1-3) mediate the facilitated transport of a variety of structurally diverse organic cations, including many drugs, toxins, and endogenous compounds. ...
The polyspecific organic cation transporters OCT1, 2, and 3 (SLC22A1-3) mediate the facilitated transport of a variety of structurall …
ACE2 negatively regulates the Warburg effect and suppresses hepatocellular carcinoma progression via reducing ROS-HIF1α activity.
Dong F, Li H, Liu L, Yao LL, Wang J, Xiang D, Ma J, Zhang G, Zhang S, Li J, Jiang SH, Hu X, Chen J, Bao Z. Dong F, et al. Int J Biol Sci. 2023 May 11;19(8):2613-2629. doi: 10.7150/ijbs.81498. eCollection 2023. Int J Biol Sci. 2023. PMID: 37215979 Free PMC article.
In this study, an integrative analysis identifies a repertoire of differentially expressed genes (DNASE1L3, SLC22A1, ACE2, CES3, CCL14, GYS2, ADH4, and CFHR3) that are inversely associated with the glycolytic phenotype in HCC. ...
In this study, an integrative analysis identifies a repertoire of differentially expressed genes (DNASE1L3, SLC22A1, ACE2, CES3, CCL1 …
Organic Anion Transporters (OAT) and Other SLC22 Transporters in Progression of Renal Cell Carcinoma.
Whisenant TC, Nigam SK. Whisenant TC, et al. Cancers (Basel). 2022 Sep 29;14(19):4772. doi: 10.3390/cancers14194772. Cancers (Basel). 2022. PMID: 36230695 Free PMC article.
This raises the question about the potential role of SLC22 transporters in cancer biology and treatment. (2) Results: In two renal cell carcinoma RNA-seq datasets found in TCGA, KIRC and KIRP, there were multiple differentially expressed (DE) SLC22 transporter genes compar …
This raises the question about the potential role of SLC22 transporters in cancer biology and treatment. (2) Results: In two renal ce …
SLC22A1-ABCB1 haplotype profiles predict imatinib pharmacokinetics in Asian patients with chronic myeloid leukemia.
Singh O, Chan JY, Lin K, Heng CC, Chowbay B. Singh O, et al. PLoS One. 2012;7(12):e51771. doi: 10.1371/journal.pone.0051771. Epub 2012 Dec 18. PLoS One. 2012. PMID: 23272163 Free PMC article.
OBJECTIVE: This study aimed to explore the influence of SLC22A1, PXR, ABCG2, ABCB1 and CYP3A5 3 genetic polymorphisms on imatinib mesylate (IM) pharmacokinetics in Asian patients with chronic myeloid leukemia (CML). ...CONCLUSION: This exploratory study suggests that SL …
OBJECTIVE: This study aimed to explore the influence of SLC22A1, PXR, ABCG2, ABCB1 and CYP3A5 3 genetic polymorphisms on imatinib mes …
109 results