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2003 1
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23 results

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Circular RNA circ-SLC7A6 acts as a tumor suppressor in non-small cell lung cancer through abundantly sponging miR-21.
Wang Y, Zheng F, Wang Z, Lu J, Zhang H. Wang Y, et al. Cell Cycle. 2020 Sep;19(17):2235-2246. doi: 10.1080/15384101.2020.1806449. Epub 2020 Aug 14. Cell Cycle. 2020. PMID: 32794418 Free PMC article.
Circular RNA (circRNA) is currently considered to be a key regulatory molecule in cancer biology. In the present study, we aimed to explore the functional and clinical roles of circ-SLC7A6 (a circRNA derived from SLC7A6 gene) in non-small cell lung cancer …
Circular RNA (circRNA) is currently considered to be a key regulatory molecule in cancer biology. In the present study, we aimed to e …
Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment.
Yang C, Ou Y, Zhou Q, Liang Y, Li W, Chen Y, Chen W, Wu S, Chen Y, Dai X, Chen X, Chen T, Jin S, Liu Y, Zhang L, Liu S, Hu Y, Zou L, Mao S, Jiang H. Yang C, et al. Cell Death Dis. 2023 Aug 15;14(8):525. doi: 10.1038/s41419-023-06050-1. Cell Death Dis. 2023. PMID: 37582769 Free PMC article.
Tumor-infiltrating CD8(+) T cells characterized an exhausted phenotype in tumors with low methionine. High expression of SLC7A6 in BCa negatively correlated with expression of CD8. Synergistic inhibition of MAT2A and SLC7A6 could overcome cisplatin resistance in imm …
Tumor-infiltrating CD8(+) T cells characterized an exhausted phenotype in tumors with low methionine. High expression of SLC7A6 in BC …
CD98 heavy chain as a prognostic biomarker and target for cancer treatment.
Xia P, Dubrovska A. Xia P, et al. Front Oncol. 2023 Sep 26;13:1251100. doi: 10.3389/fonc.2023.1251100. eCollection 2023. Front Oncol. 2023. PMID: 37823053 Free PMC article. Review.
CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y(+)LAT1 (SLC7A7), y(+)LAT2 (SLC7A6), xCT (SLC7A11) and Asc1 (SLC7A10) providing their recruitment to the plasma membrane. ...A high expression of CD98hc has been linked to clinical prognosis and response to ch …
CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y(+)LAT1 (SLC7A7), y(+)LAT2 (SLC7A6), xCT (SLC7A11) and Asc1 (SLC7A10) …
Baicalein improves the chemoresistance of ovarian cancer through regulation of CirSLC7A6.
Li S, Yi Z, Li M, Zhu Z. Li S, et al. J Ovarian Res. 2023 Nov 8;16(1):212. doi: 10.1186/s13048-023-01285-0. J Ovarian Res. 2023. PMID: 37940982 Free PMC article.
Baicalein alone and in combination with cisplatin notably reduced the expression of CirSLC7A6 and SLC7A6, and increased the expression of miR-2682-5p in the A2780/CDDP shCirSLC7A6 cell xenograft. ...CONCLUSIONS: Treatment with baicalein improved the sensitivity of ovarian …
Baicalein alone and in combination with cisplatin notably reduced the expression of CirSLC7A6 and SLC7A6, and increased the expressio …
STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1.
Chen X, Wang Z, Zhao X, Zhang L, Zhou L, Li X, Ge C, Zhao F, Chen T, Xie H, Cui Y, Tian H, Li H, Yao M, Li J. Chen X, et al. Oncogene. 2022 Apr;41(17):2492-2504. doi: 10.1038/s41388-022-02273-2. Epub 2022 Mar 21. Oncogene. 2022. PMID: 35314791
Mechanistically, CDYL2 down-regulates solute carrier family 7 member 6 (SLC7A6) by decreasing the enrichment of H3K4me3 on the promoter region of SLC7A6. ...Consistently, CDYL2 expression correlated significantly with STAT5A and SLC7A6 expression in HCC. Coll …
Mechanistically, CDYL2 down-regulates solute carrier family 7 member 6 (SLC7A6) by decreasing the enrichment of H3K4me3 on the promot …
RNA helicase DHX15 exemplifies a unique dependency in acute leukemia.
Guo H, Xu J, Xing P, Li Q, Wang D, Tang C, Palhais B, Roels J, Liu J, Pan S, Huang J, Liu Z, Zhu P, Taghon T, Qing G, Van Vlierberghe P, Liu H. Guo H, et al. Haematologica. 2023 Aug 1;108(8):2029-2043. doi: 10.3324/haematol.2022.282066. Haematologica. 2023. PMID: 36861414 Free PMC article.
RNA-binding proteins (RBP) have emerged as essential regulators that control gene expression and modulate multiple cancer traits. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from transformation of T-cell progenitors that norm …
RNA-binding proteins (RBP) have emerged as essential regulators that control gene expression and modulate multiple cancer traits. T-c …
Identifying essential genes in genome-scale metabolic models of consensus molecular subtypes of colorectal cancer.
Cheng CT, Lai JM, Chang PM, Hong YR, Huang CF, Wang FS. Cheng CT, et al. PLoS One. 2023 May 19;18(5):e0286032. doi: 10.1371/journal.pone.0286032. eCollection 2023. PLoS One. 2023. PMID: 37205704 Free PMC article.
On the basis of four objectives, the present study developed a framework for identifying essential targets that lead to cancer cell death and evaluating metabolic flux perturbations in normal cells that have been caused by cancer treatment. ...The results reveal tha …
On the basis of four objectives, the present study developed a framework for identifying essential targets that lead to cancer cell d …
Long non-coding RNA PVT1-5 promotes cell proliferation by regulating miR-126/SLC7A5 axis in lung cancer.
Li H, Chen S, Liu J, Guo X, Xiang X, Dong T, Ran P, Li Q, Zhu B, Zhang X, Wang D, Xiao C, Zheng S. Li H, et al. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2350-2355. doi: 10.1016/j.bbrc.2017.12.114. Epub 2017 Dec 23. Biochem Biophys Res Commun. 2018. PMID: 29277611
Dysregulated long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in the development of human cancers. The lncRNA plasmacytoma variant translocation 1 (PVT1) is reported to be an oncogene in a variety of cancers. However, the roles of PVT1-5 and its …
Dysregulated long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in the development of human cancers. The lncRNA pla …
Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor.
Rii J, Sakamoto S, Sugiura M, Kanesaka M, Fujimoto A, Yamada Y, Maimaiti M, Ando K, Wakai K, Xu M, Imamura Y, Shindo N, Hirota T, Kaneda A, Kanai Y, Ikehara Y, Anzai N, Ichikawa T. Rii J, et al. Cancer Sci. 2021 Sep;112(9):3871-3883. doi: 10.1111/cas.14991. Epub 2021 Jul 8. Cancer Sci. 2021. PMID: 34050700 Free PMC article.
L-type amino acid transporter 3 (LAT3, SLC43A1) is abundantly expressed in prostate cancer (PC) and is thought to play an essential role in PC progression through the cellular uptake of essential amino acids. ...
L-type amino acid transporter 3 (LAT3, SLC43A1) is abundantly expressed in prostate cancer (PC) and is thought to play an essential r …
23 results