Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 1
2005 1
2011 3
2012 3
2013 1
2014 5
2015 2
2016 2
2018 4
2019 4
2020 7
2021 7
2022 1
2023 5
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

48 results

Results by year

Filters applied: . Clear all
Page 1
Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells.
Montero S, Seras-Franzoso J, Andrade F, Martinez-Trucharte F, Vilar-Hernández M, Quesada M, Xandri H, Arango D, Abasolo I, Rafael D, Schwartz S Jr. Montero S, et al. Pharmaceutics. 2020 Feb 21;12(2):185. doi: 10.3390/pharmaceutics12020185. Pharmaceutics. 2020. PMID: 32098204 Free PMC article.
SMC2 over-expression has been related with tumorigenesis and cancer malignancy and its inhibition is regarded as a potential therapeutic strategy even though no drugs are currently available. Here, we propose to inhibit SMC2 by intracellular delivery of speci …
SMC2 over-expression has been related with tumorigenesis and cancer malignancy and its inhibition is regarded as a potential t …
Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.
Feng Y, Liu H, Duan B, Liu Z, Abbruzzese J, Walsh KM, Zhang X, Wei Q. Feng Y, et al. Carcinogenesis. 2019 Jun 10;40(4):521-528. doi: 10.1093/carcin/bgz029. Carcinogenesis. 2019. PMID: 30794721 Free PMC article.
Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic cancer. To test this hypothesis, we used three large publically available pancreatic cancer genome-wide association study (GWAS) datasets (PanScan I, II/III a …
Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic cancer. To test this hypo …
Identification of SMC2 and SMC4 as prognostic markers in breast cancer through bioinformatics analysis.
Pei L, Li Y, Gu H, Wang S, Wu W, Fan S, Shi X, Si X. Pei L, et al. Clin Transl Oncol. 2024 May 21. doi: 10.1007/s12094-024-03521-5. Online ahead of print. Clin Transl Oncol. 2024. PMID: 38773061
BACKGROUND: Breast cancer (BRCA) is one of the most common malignant tumors. The structural maintenance of chromosome (SMC) gene family has been shown to play an important role in human cancers. ...Tumor growth and weights were significantly decreased in si-SMC2 …
BACKGROUND: Breast cancer (BRCA) is one of the most common malignant tumors. The structural maintenance of chromosome (SMC) gene fami …
A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer.
Zhong J, Jermusyk A, Wu L, Hoskins JW, Collins I, Mocci E, Zhang M, Song L, Chung CC, Zhang T, Xiao W, Albanes D, Andreotti G, Arslan AA, Babic A, Bamlet WR, Beane-Freeman L, Berndt S, Borgida A, Bracci PM, Brais L, Brennan P, Bueno-de-Mesquita B, Buring J, Canzian F, Childs EJ, Cotterchio M, Du M, Duell EJ, Fuchs C, Gallinger S, Gaziano JM, Giles GG, Giovannucci E, Goggins M, Goodman GE, Goodman PJ, Haiman C, Hartge P, Hasan M, Helzlsouer KJ, Holly EA, Klein EA, Kogevinas M, Kurtz RJ, LeMarchand L, Malats N, Männistö S, Milne R, Neale RE, Ng K, Obazee O, Oberg AL, Orlow I, Patel AV, Peters U, Porta M, Rothman N, Scelo G, Sesso HD, Severi G, Sieri S, Silverman D, Sund M, Tjønneland A, Thornquist MD, Tobias GS, Trichopoulou A, Van Den Eeden SK, Visvanathan K, Wactawski-Wende J, Wentzensen N, White E, Yu H, Yuan C, Zeleniuch-Jacquotte A, Hoover R, Brown K, Kooperberg C, Risch HA, Jacobs EJ, Li D, Yu K, Shu XO, Chanock SJ, Wolpin BM, Stolzenberg-Solomon RZ, Chatterjee N, Klein AP, Smith JP, Kraft P, Shi J, Petersen GM, Zheng W, Amundadottir LT. Zhong J, et al. J Natl Cancer Inst. 2020 Oct 1;112(10):1003-1012. doi: 10.1093/jnci/djz246. J Natl Cancer Inst. 2020. PMID: 31917448 Free PMC article.
METHODS: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. ...RESULTS: We identified 25 genes w …
METHODS: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcripto …
SMC2 knockdown inhibits malignant progression of lung adenocarcinoma by upregulating BTG2 expression.
He Y, Wang Y, Luo Z, Zhang X, Bai H, Wang J. He Y, et al. Cell Signal. 2024 May 8;120:111216. doi: 10.1016/j.cellsig.2024.111216. Online ahead of print. Cell Signal. 2024. PMID: 38729325 Free article.
Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer worldwide. Structural maintenance of chromosomes 2 (SMC2) serves as a predictor of poor prognosis across various cancer types. This study aims to explore the role and underlying mechanism …
Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer worldwide. Structural maintenance of chromosomes 2 (SMC2 …
Multiscale protein networks systematically identify aberrant protein interactions and oncogenic regulators in seven cancer types.
Song WM, Elmas A, Farias R, Xu P, Zhou X, Hopkins B, Huang KL, Zhang B. Song WM, et al. J Hematol Oncol. 2023 Dec 15;16(1):120. doi: 10.1186/s13045-023-01517-2. J Hematol Oncol. 2023. PMID: 38102665 Free PMC article.
Cross-cancer comparison identified highly preserved protein modules showing robust pan-cancer interactions and identified endoplasmic reticulum-associated degradation (ERAD) and N-acetyltransferase activity as the central functional axes. We further utilized these n …
Cross-cancer comparison identified highly preserved protein modules showing robust pan-cancer interactions and identified endo …
Structural maintenance of chromosomes 2 is identified as an oncogene in bladder cancer in vitro and in vivo.
Han YH, Wan Y, Xiong H, Sun GL. Han YH, et al. Neoplasma. 2020 Mar;67(2):364-370. doi: 10.4149/neo_2020_190510N419. Epub 2020 Jan 27. Neoplasma. 2020. PMID: 31986889
Structural maintenance of chromosomes 2 (SMC2) was inhibited after TUG1 knockdown. The depletion of TUG1 or SMC2 led to G2/M phase arrest in bladder cancer cells. ...Our data suggest that SMC2 is an oncogene in bladder cancer and depletion of …
Structural maintenance of chromosomes 2 (SMC2) was inhibited after TUG1 knockdown. The depletion of TUG1 or SMC2 led to G2/M p …
A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk.
Liu D, Zhou D, Sun Y, Zhu J, Ghoneim D, Wu C, Yao Q, Gamazon ER, Cox NJ, Wu L. Liu D, et al. Cancer Res. 2020 Oct 15;80(20):4346-4354. doi: 10.1158/0008-5472.CAN-20-1353. Epub 2020 Sep 9. Cancer Res. 2020. PMID: 32907841 Free PMC article.
Pancreatic cancer is among the most well-characterized cancer types, yet a large proportion of the heritability of pancreatic cancer risk remains unclear. ...These prediction models were applied to the genetic data of 8,275 pancreatic cancer cases and …
Pancreatic cancer is among the most well-characterized cancer types, yet a large proportion of the heritability of pancreatic …
Mutational and expressional analysis of SMC2 gene in gastric and colorectal cancers with microsatellite instability.
Je EM, Yoo NJ, Lee SH. Je EM, et al. APMIS. 2014 Jun;122(6):499-504. doi: 10.1111/apm.12193. Epub 2014 Feb 1. APMIS. 2014. PMID: 24483990
The mutations were detected exclusively in MSI-H cancers, but not in MSI-L/MSS cancers. Loss of SMC2 expression was observed in 22% of GC and 25% of CRC. Of note, all of the cancers with SMC2 frameshift mutations displayed loss of SMC2 ex …
The mutations were detected exclusively in MSI-H cancers, but not in MSI-L/MSS cancers. Loss of SMC2 expression was obs …
Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.
Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K. Murakami-Tonami Y, et al. Cell Cycle. 2014;13(7):1115-31. doi: 10.4161/cc.27983. Epub 2014 Feb 7. Cell Cycle. 2014. PMID: 24553121 Free PMC article.
This study demonstrates that the gene encoding the condensin complex subunit SMC2 is transcriptionally regulated by MYCN. SMC2 also transcriptionally regulates DNA damage response genes in cooperation with MYCN. ...Finally, this study found that patients bearing MYC …
This study demonstrates that the gene encoding the condensin complex subunit SMC2 is transcriptionally regulated by MYCN. SMC2 …
48 results