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Page 1
SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression.
Bastos N, Castaldo SA, Adem B, Machado JC, Melo CA, Melo SA. Bastos N, et al. J Transl Med. 2023 Aug 28;21(1):578. doi: 10.1186/s12967-023-04448-1. J Transl Med. 2023. PMID: 37641131 Free PMC article.
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males and females in the US, only lagging behind lung cancer. ...SMC3 methylation is present in human PDAC …
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer …
Hydrogen gas inhibits lung cancer progression through targeting SMC3.
Wang D, Wang L, Zhang Y, Zhao Y, Chen G. Wang D, et al. Biomed Pharmacother. 2018 Aug;104:788-797. doi: 10.1016/j.biopha.2018.05.055. Epub 2018 May 29. Biomed Pharmacother. 2018. PMID: 29852353
Besides, we confirmed the structural maintenance of chromosomes 3 (SMC3) and H(2) on the progression of lung cancer in vitro and vivo. ...All data suggested that H(2) inhibited lung cancer progression through down-regulating SMC3, a regulator for chrom …
Besides, we confirmed the structural maintenance of chromosomes 3 (SMC3) and H(2) on the progression of lung cancer in vitro a …
Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops.
Bastié N, Chapard C, Dauban L, Gadal O, Beckouët F, Koszul R. Bastié N, et al. Nat Struct Mol Biol. 2022 Jun;29(6):575-585. doi: 10.1038/s41594-022-00780-0. Epub 2022 Jun 16. Nat Struct Mol Biol. 2022. PMID: 35710835
We demonstrate that Scc2, which stimulates cohesin ATPase activity, is also essential for cohesin translocation, driving loop expansion in vivo. Smc3 acetylation during the S phase counteracts this activity through the stabilization of Pds5, which finely tunes the size and …
We demonstrate that Scc2, which stimulates cohesin ATPase activity, is also essential for cohesin translocation, driving loop expansion in v …
The multifaceted roles of cohesin in cancer.
Di Nardo M, Pallotta MM, Musio A. Di Nardo M, et al. J Exp Clin Cancer Res. 2022 Mar 14;41(1):96. doi: 10.1186/s13046-022-02321-5. J Exp Clin Cancer Res. 2022. PMID: 35287703 Free PMC article. Review.
In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity. The core complex subunits SMC1A, SMC3, STAG1/2, and RAD21 as well as its modulators, have been found to be recurrently mutated in …
In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integri …
Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model.
Arkoun B, Robert E, Boudia F, Mazzi S, Dufour V, Siret A, Mammasse Y, Aid Z, Vieira M, Imanci A, Aglave M, Cambot M, Petermann R, Souquere S, Rameau P, Catelain C, Diot R, Tachdjian G, Hermine O, Droin N, Debili N, Plo I, Malinge S, Soler E, Raslova H, Mercher T, Vainchenker W. Arkoun B, et al. J Clin Invest. 2022 Jul 15;132(14):e156290. doi: 10.1172/JCI156290. J Clin Invest. 2022. PMID: 35587378 Free PMC article.
We modeled the megakaryocyte differentiation defect through stepwise gene editing of GATA1s, SMC3+/-, and MPLW515K, providing 20 different T21 or disomy 21 (D21) induced pluripotent stem cell (iPSC) clones. GATA1s profoundly reshaped iPSC-derived hematopoietic architecture …
We modeled the megakaryocyte differentiation defect through stepwise gene editing of GATA1s, SMC3+/-, and MPLW515K, providing 20 diff …
3D CRISPR screen in prostate cancer cells reveals PARP inhibitor sensitization through TBL1XR1-SMC3 interaction.
Zhang H, Gao H, Gu Y, John A, Wei L, Huang M, Yu J, Adeosun AA, Weinshilboum RM, Wang L. Zhang H, et al. Front Oncol. 2022 Nov 29;12:999302. doi: 10.3389/fonc.2022.999302. eCollection 2022. Front Oncol. 2022. PMID: 36523978 Free PMC article.
One of these genes, TBL1XR1, regulates sensitivity to PARPi in prostate cancer cells. Mechanistically, we show that TBL1XR1 interacts with and stabilizes SMC3 on chromatin and promotes gammaH2AX spreading along the chromatin of the cells under DNA replication stress …
One of these genes, TBL1XR1, regulates sensitivity to PARPi in prostate cancer cells. Mechanistically, we show that TBL1XR1 interacts …
Cohesin mutations in human cancer.
Hill VK, Kim JS, Waldman T. Hill VK, et al. Biochim Biophys Acta. 2016 Aug;1866(1):1-11. doi: 10.1016/j.bbcan.2016.05.002. Epub 2016 May 17. Biochim Biophys Acta. 2016. PMID: 27207471 Free PMC article. Review.
Recent studies have demonstrated that genes encoding cohesin subunits are somatically mutated in a wide range of human cancers. STAG2 is the most commonly mutated subunit, and in a recent analysis was identified as one of only 12 genes that are significantly mutated in fou …
Recent studies have demonstrated that genes encoding cohesin subunits are somatically mutated in a wide range of human cancers. STAG2 …
ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex.
Fu J, Zhou S, Xu H, Liao L, Shen H, Du P, Zheng X. Fu J, et al. Nucleic Acids Res. 2023 Aug 11;51(14):7376-7391. doi: 10.1093/nar/gkad533. Nucleic Acids Res. 2023. PMID: 37377435 Free PMC article.
Furthermore, depletion of ESCO2 in both colorectal cancer cells and xenografted nude mice sensitizes cancer cells to chemotherapeutic drugs. Collectively, our results reveal a molecular mechanism for the ATM-ESCO2-SMC3 axis in DSB repair and genome integrity …
Furthermore, depletion of ESCO2 in both colorectal cancer cells and xenografted nude mice sensitizes cancer cells to chemother …
Cohesin mutations in myeloid malignancies.
Jann JC, Tothova Z. Jann JC, et al. Blood. 2021 Aug 26;138(8):649-661. doi: 10.1182/blood.2019004259. Blood. 2021. PMID: 34157074 Free PMC article. Review.
It is essential for sister chromatid cohesion, chromatin organization, transcriptional regulation, and DNA damage repair and plays a major role in dynamically shaping the genome architecture and maintaining DNA integrity. The core complex subunits STAG2, RAD21, SMC1, and SMC3 …
It is essential for sister chromatid cohesion, chromatin organization, transcriptional regulation, and DNA damage repair and plays a major r …
Heterozygous loss-of-function SMC3 variants are associated with variable and incompletely penetrant growth and developmental features.
Ansari M, Faour KNW, Shimamura A, Grimes G, Kao EM, Denhoff ER, Blatnik A, Ben-Isvy D, Wang L, Helm BM, Firth H, Breman AM, Bijlsma EK, Iwata-Otsubo A, de Ravel TJL, Fusaro V, Fryer A, Nykamp K, Stühn LG, Haack TB, Korenke GC, Constantinou P, Bujakowska KM, Low KJ, Place E, Humberson J, Napier MP, Hoffman J, Juusola J, Deardorff MA, Shao W, Rockowitz S, Krantz I, Kaur M, Raible S, Kliesch S, Singer-Berk M, Groopman E, DiTroia S, Ballal S, Srivastava S, Rothfelder K, Biskup S, Rzasa J, Kerkhof J, McConkey H, O'Donnell-Luria A, Sadikovic B, Hilton S, Banka S, Tüttelmann F, Conrad D, Talkowski ME, FitzPatrick DR, Boone PM. Ansari M, et al. medRxiv [Preprint]. 2023 Sep 28:2023.09.27.23294269. doi: 10.1101/2023.09.27.23294269. medRxiv. 2023. PMID: 37808847 Free PMC article. Updated. Preprint.
Comparisons to individuals with SMC3 missense/in-frame indel variants demonstrated a milder presentation in pLoF carriers. ...Analyses of transcriptomic and epigenetic data suggest that SMC3 pLoF variants reduce SMC3 expression but do not result in a blood DN …
Comparisons to individuals with SMC3 missense/in-frame indel variants demonstrated a milder presentation in pLoF carriers. ...Analyse …
183 results