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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1984 1
1991 1
1992 1
1996 2
1997 2
1998 4
1999 9
2000 4
2001 7
2002 6
2003 11
2004 18
2005 20
2006 40
2007 25
2008 42
2009 58
2010 69
2011 84
2012 106
2013 118
2014 137
2015 120
2016 129
2017 113
2018 143
2019 134
2020 132
2021 136
2022 122
2023 99
2024 45

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1,703 results

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Page 1
The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Skoda AM, Simovic D, Karin V, Kardum V, Vranic S, Serman L. Skoda AM, et al. Bosn J Basic Med Sci. 2018 Feb 20;18(1):8-20. doi: 10.17305/bjbms.2018.2756. Bosn J Basic Med Sci. 2018. PMID: 29274272 Free PMC article. Review.
Deregulation of the Hh signaling pathway is associated with developmental anomalies and cancer, including Gorlin syndrome, and sporadic cancers, such as basal cell carcinoma, medulloblastoma, pancreatic, breast, colon, ovarian, and small-cell lung carcinomas. ...Sev …
Deregulation of the Hh signaling pathway is associated with developmental anomalies and cancer, including Gorlin syndrome, and sporad …
Hedgehog signaling mechanism and role in cancer.
Jiang J. Jiang J. Semin Cancer Biol. 2022 Oct;85:107-122. doi: 10.1016/j.semcancer.2021.04.003. Epub 2021 Apr 6. Semin Cancer Biol. 2022. PMID: 33836254 Free PMC article. Review.
Deregulation of these signaling pathways has been implicated in a wide range of human diseases including cancer. One such pathway is the Hedgehog (Hh) pathway, which was originally discovered in Drosophila and later found to play a fundamental role in human development and …
Deregulation of these signaling pathways has been implicated in a wide range of human diseases including cancer. One such pathway is …
Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures.
Khan NH, Mir M, Qian L, Baloch M, Ali Khan MF, Rehman AU, Ngowi EE, Wu DD, Ji XY. Khan NH, et al. J Adv Res. 2021 Jun 16;36:223-247. doi: 10.1016/j.jare.2021.06.014. eCollection 2022 Feb. J Adv Res. 2021. PMID: 35127174 Free PMC article. Review.
BACKGROUND: Skin cancer has been the leading type of cancer worldwide. Melanoma and non-melanoma skin cancers are now the most common types of skin cancer that have been reached to epidemic proportion. Based on the rapid prevalence of skin cancers …
BACKGROUND: Skin cancer has been the leading type of cancer worldwide. Melanoma and non-melanoma skin cancers are now t …
State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures.
Espinosa-Bustos C, Mella J, Soto-Delgado J, Salas CO. Espinosa-Bustos C, et al. Future Med Chem. 2019 Mar;11(6):617-638. doi: 10.4155/fmc-2018-0497. Epub 2019 Mar 26. Future Med Chem. 2019. PMID: 30912670 Review.
Since the Hedgehog signaling pathway has been associated with cancer, it has emerged as a therapeutic target for cancer therapy. ...However, early resistance of these drugs has spawned the need to understand the molecular bases of this phenomena. We therefore review …
Since the Hedgehog signaling pathway has been associated with cancer, it has emerged as a therapeutic target for cancer therap …
The Role of Smoothened in Cancer.
Jeng KS, Sheen IS, Leu CM, Tseng PH, Chang CF. Jeng KS, et al. Int J Mol Sci. 2020 Sep 18;21(18):6863. doi: 10.3390/ijms21186863. Int J Mol Sci. 2020. PMID: 32962123 Free PMC article. Review.
The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. ...In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apopto …
The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. …
Cancer interception.
Blackburn EH. Blackburn EH. Cancer Prev Res (Phila). 2011 Jun;4(6):787-92. doi: 10.1158/1940-6207.CAPR-11-0195. Cancer Prev Res (Phila). 2011. PMID: 21636545
Risk avoidance approaches are certainly important, but other approaches are important as well, as exemplified by the irony that most new lung cancers occur in former smokers, or current avoiders. Cancer interception is the active way of combating cancer and c …
Risk avoidance approaches are certainly important, but other approaches are important as well, as exemplified by the irony that most new lun …
Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer.
Mohd Ariffin K, Abd Ghani F, Hussin H, Md Said S, Yunus R, Veerakumarasivam A, Abdullah MA. Mohd Ariffin K, et al. Malays J Pathol. 2021 Apr;43(1):49-54. Malays J Pathol. 2021. PMID: 33903305 Free article.
SMO expression showed statistically significant association with higher grade (p=0.001) and higher stage (p=0.042) of bladder cancer. ...CONCLUSION: These findings indicate that SMO expression may be a poor prognostic marker in bladder cancer....
SMO expression showed statistically significant association with higher grade (p=0.001) and higher stage (p=0.042) of bladder canc …
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K. Tanese K. Curr Treat Options Oncol. 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. Curr Treat Options Oncol. 2019. PMID: 30741348 Review.
Basal cell carcinomas (BCCs) are common skin cancers that tend to appear on sun-exposed skin. Pathobiologically, activation of the Hedgehog signaling pathway characterizes the majority of cases. ...
Basal cell carcinomas (BCCs) are common skin cancers that tend to appear on sun-exposed skin. Pathobiologically, activation of the He …
Targeting GLI Transcription Factors in Cancer.
Didiasova M, Schaefer L, Wygrecka M. Didiasova M, et al. Molecules. 2018 Apr 24;23(5):1003. doi: 10.3390/molecules23051003. Molecules. 2018. PMID: 29695137 Free PMC article. Review.
Aberrant activation of hedgehog (Hh) signaling has been observed in a wide variety of tumors and accounts for more than 25% of human cancer deaths. Inhibitors targeting the Hh signal transducer Smoothened (SMO) are widely used and display a good initial efficacy in …
Aberrant activation of hedgehog (Hh) signaling has been observed in a wide variety of tumors and accounts for more than 25% of human canc …
SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features.
Li T, Liao X, Lochhead P, Morikawa T, Yamauchi M, Nishihara R, Inamura K, Kim SA, Mima K, Sukawa Y, Kuchiba A, Imamura Y, Baba Y, Shima K, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S, Qian ZR. Li T, et al. Ann Surg Oncol. 2014 Dec;21(13):4164-73. doi: 10.1245/s10434-014-3888-y. Epub 2014 Jul 15. Ann Surg Oncol. 2014. PMID: 25023548 Free PMC article.
SMO expression was not significantly associated with colorectal cancer-specific or overall survival. However, in CIMP-high tumors, but not CIMP-low/0 tumors, SMO expression was significantly associated with better colorectal cancer-specific survival (l …
SMO expression was not significantly associated with colorectal cancer-specific or overall survival. However, in CIMP-high tum …
1,703 results