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Page 1
The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer.
Raja S, Van Houten B. Raja S, et al. Int J Mol Sci. 2021 Feb 17;22(4):1981. doi: 10.3390/ijms22041981. Int J Mol Sci. 2021. PMID: 33671338 Free PMC article. Review.
Rodent studies suggest that, while SMUG1 shares substrate specificity with another uracil glycosylase UNG2, loss of SMUG1 can have unique cellular phenotypes. This review highlights the multiple roles SMUG1 may play in preserving genome stability, and how the …
Rodent studies suggest that, while SMUG1 shares substrate specificity with another uracil glycosylase UNG2, loss of SMUG1 can …
REV1-Polzeta maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.
Taglialatela A, Leuzzi G, Sannino V, Cuella-Martin R, Huang JW, Wu-Baer F, Baer R, Costanzo V, Ciccia A. Taglialatela A, et al. Mol Cell. 2021 Oct 7;81(19):4008-4025.e7. doi: 10.1016/j.molcel.2021.08.016. Epub 2021 Sep 10. Mol Cell. 2021. PMID: 34508659 Free PMC article.
Here, we report that these cells accumulate ssDNA gaps and spontaneous mutations during unperturbed DNA replication due to repriming by the DNA primase-polymerase PRIMPOL. Gap accumulation requires the DNA glycosylase SMUG1 and is exacerbated by depletion of the translesio …
Here, we report that these cells accumulate ssDNA gaps and spontaneous mutations during unperturbed DNA replication due to repriming by the …
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.
Fugger K, Bajrami I, Silva Dos Santos M, Young SJ, Kunzelmann S, Kelly G, Hewitt G, Patel H, Goldstone R, Carell T, Boulton SJ, MacRae J, Taylor IA, West SC. Fugger K, et al. Science. 2021 Apr 9;372(6538):156-165. doi: 10.1126/science.abb4542. Science. 2021. PMID: 33833118 Free PMC article.
Mutations in the BRCA1 or BRCA2 tumor suppressor genes predispose individuals to breast and ovarian cancer. In the clinic, these cancers are treated with inhibitors that target poly(ADP-ribose) polymerase (PARP). ...Because genomic hmdU is a key determinant of PARPi …
Mutations in the BRCA1 or BRCA2 tumor suppressor genes predispose individuals to breast and ovarian cancer. In the clinic, these c …
UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties.
Jang S, Raja SJ, Roginskaya V, Schaich MA, Watkins SC, Van Houten B. Jang S, et al. Nucleic Acids Res. 2023 Jun 9;51(10):4881-4898. doi: 10.1093/nar/gkad206. Nucleic Acids Res. 2023. PMID: 36971122 Free PMC article.
Electrophoretic mobility shift assays indicated that UV-DDB displaced SMUG1 from abasic site products. Single-molecule analysis revealed that UV-DDB decreases the half-life of SMUG1 on DNA by 8-fold. Immunofluorescence experiments demonstrated that cellular treatmen …
Electrophoretic mobility shift assays indicated that UV-DDB displaced SMUG1 from abasic site products. Single-molecule analysis revea …
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
Carracedo S, Lirussi L, Alsøe L, Segers F, Wang C, Bartosova Z, Bohov P, Tekin NB, Kong XY, Esbensen QY, Chen L, Wennerström A, Kroustallaki P, Ceolotto D, Tönjes A, Berge RK, Bruheim P, Wong G, Böttcher Y, Halvorsen B, Nilsen H. Carracedo S, et al. DNA Repair (Amst). 2022 Dec;120:103410. doi: 10.1016/j.dnarep.2022.103410. Epub 2022 Oct 3. DNA Repair (Amst). 2022. PMID: 36244177
Recently, a correlation between the base excision repair enzyme SMUG1 and metabolic homeostasis was identified. As the molecular mechanisms remain unknown, we exploited a SMUG1-knockout mouse model to gain insights into this association by characterizing the liver p …
Recently, a correlation between the base excision repair enzyme SMUG1 and metabolic homeostasis was identified. As the molecular mech …
A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours.
Lirussi L, Ayyildiz D, Liu Y, Montaldo NP, Carracedo S, Aure MR, Jobert L, Tekpli X, Touma J, Sauer T, Dalla E, Kristensen VN, Geisler J, Piazza S, Tell G, Nilsen H. Lirussi L, et al. Nucleic Acids Res. 2022 Oct 14;50(18):10449-10468. doi: 10.1093/nar/gkac807. Nucleic Acids Res. 2022. PMID: 36156150 Free PMC article.
SMUG1 status has been associated with cancer risk and therapeutic response in breast carcinomas and other cancer types. ...Interestingly, we identified hsa-let-7b-5p microRNA as an upstream regulator of the SMUG1 interactome. Expression of SMUG1 …
SMUG1 status has been associated with cancer risk and therapeutic response in breast carcinomas and other cancer types. …
Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.
Cumova A, Vymetalkova V, Opattova A, Bouskova V, Pardini B, Kopeckova K, Kozevnikovova R, Lickova K, Ambrus M, Vodickova L, Naccarati A, Soucek P, Vodicka P. Cumova A, et al. Mutagenesis. 2021 Aug 27;36(4):269-279. doi: 10.1093/mutage/geab017. Mutagenesis. 2021. PMID: 34097065
We have previously reported a significant association of miRSNPs in the SMUG1 and NEIL2 genes with overall survival in colorectal cancer patients. SMUG1 and NEIL2 are DNA glycosylases involved in base excision DNA repair. ...
We have previously reported a significant association of miRSNPs in the SMUG1 and NEIL2 genes with overall survival in colorectal …
Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.
Abdel-Fatah TM, Albarakati N, Bowell L, Agarwal D, Moseley P, Hawkes C, Ball G, Chan S, Ellis IO, Madhusudan S. Abdel-Fatah TM, et al. Breast Cancer Res Treat. 2013 Dec;142(3):515-27. doi: 10.1007/s10549-013-2769-6. Epub 2013 Nov 20. Breast Cancer Res Treat. 2013. PMID: 24253812
We investigated SMUG1 mRNA expression in 249 primary breast cancers. SMUG1 protein expression was investigated in 1,165 breast tumours randomised into two cohorts [training set (n = 583) and test set (n = 582)]. ...Our study suggests that low SMUG1 exp …
We investigated SMUG1 mRNA expression in 249 primary breast cancers. SMUG1 protein expression was investigated in 1,165 …
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Kemmerich K, Dingler FA, Rada C, Neuberger MS. Kemmerich K, et al. Nucleic Acids Res. 2012 Jul;40(13):6016-25. doi: 10.1093/nar/gks259. Epub 2012 Mar 24. Nucleic Acids Res. 2012. PMID: 22447450 Free PMC article.
Both Smug1-knockout and Smug1/Ung-double knockout mice breed normally and remain apparently healthy beyond 1 year of age. However, combined deficiency in SMUG1 and UNG exacerbates the cancer predisposition of Msh2(-/-) mice suggesting that when both ba …
Both Smug1-knockout and Smug1/Ung-double knockout mice breed normally and remain apparently healthy beyond 1 year of age. Howe …
Ablation of SMUG1 Reduces Cell Viability and Increases UVC-Mediated Apoptosis in Hepatocarcinoma HepG2 Cells.
An MJ, Shin GS, Lee HM, Kim JW. An MJ, et al. Genes (Basel). 2021 Jan 30;12(2):201. doi: 10.3390/genes12020201. Genes (Basel). 2021. PMID: 33573186 Free PMC article.
Moreover, the apoptotic cells by DNA damage accumulation were markedly increased in SMUG1 KD and KO cells after ultraviolet C irradiation. Transcriptomic analysis using RNA-seq revealed that SMUG1 was involved in gene sets expression including cell cycle transition …
Moreover, the apoptotic cells by DNA damage accumulation were markedly increased in SMUG1 KD and KO cells after ultraviolet C irradia …
89 results