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17 results

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Page 1
Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of beta-catenin.
Rines AK, Burke MA, Fernandez RP, Volpert OV, Ardehali H. Rines AK, et al. FASEB J. 2012 Nov;26(11):4685-95. doi: 10.1096/fj.12-212282. Epub 2012 Aug 8. FASEB J. 2012. PMID: 22874833 Free PMC article.
Furthermore, SNRK inhibited colon cancer cell proliferation, and CacyBP down-regulation reversed the SNRK-mediated decrease in proliferation and beta-catenin. ...SNRK transcript levels were reduced in human colon tumors compared to normal tissue by 35. …
Furthermore, SNRK inhibited colon cancer cell proliferation, and CacyBP down-regulation reversed the SNRK-mediated decr …
SNRK: a metabolic regulator with multifaceted role in development and disease.
Thirugnanam K, Ramchandran R. Thirugnanam K, et al. Vessel Plus. 2020;4:26. Epub 2020 Aug 21. Vessel Plus. 2020. PMID: 32968716 Free PMC article.
SNRK is an important mediator in maintaining cellular metabolic homeostasis. ...Finally, we review SNRK's potential as a target in various metabolic dysfunction-associated diseases such as cardiovascular diseases, diabetes, obesity, and cancer. ...
SNRK is an important mediator in maintaining cellular metabolic homeostasis. ...Finally, we review SNRK's potential as a targe …
Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features.
Hopp EE, Cossette SM, Kumar SN, Eastwood D, Ramchandran R, Bishop E. Hopp EE, et al. Cancer Invest. 2017 Aug 9;35(7):456-462. doi: 10.1080/07357907.2017.1337781. Epub 2017 Jul 19. Cancer Invest. 2017. PMID: 28722495 Free PMC article.
Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in benign and malignant human ovarian tissue using immunohistochemistry and qPCR. ...The most strongly stained malignant SNRK+ nuclei we …
Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in …
LKB1 signaling and patient survival outcomes in hepatocellular carcinoma.
Nguyen K, Hebert K, McConnell E, Cullen N, Cheng T, Awoyode S, Martin E, Chen W, Wu T, Alahari SK, Izadpanah R, Collins-Burow BM, Lee SB, Drewry DH, Burow ME. Nguyen K, et al. Pharmacol Res. 2023 Jun;192:106757. doi: 10.1016/j.phrs.2023.106757. Epub 2023 Apr 5. Pharmacol Res. 2023. PMID: 37023992 Free article. Review.
Furthermore, liver cancer is the most common cause of death associated with cirrhosis and is the 3rd leading cause of global cancer deaths. ...Furthermore, LKB1 signaling has been found to be involved in many cancers with most reports identifying LKB1 to have …
Furthermore, liver cancer is the most common cause of death associated with cirrhosis and is the 3rd leading cause of global cance …
Primary vascular tumours of the kidney.
Omiyale AO. Omiyale AO. World J Clin Oncol. 2021 Dec 24;12(12):1157-1168. doi: 10.5306/wjco.v12.i12.1157. World J Clin Oncol. 2021. PMID: 35070735 Free PMC article. Review.
This article summarizes the clinical and pathological features of primary renal angiosarcoma and anastomosing haemangioma of the kidney including epidemiology, genetics, and prognosis. Renal anastomosing haemangiomas are benign neoplasms characterized by anastomosing capil …
This article summarizes the clinical and pathological features of primary renal angiosarcoma and anastomosing haemangioma of the kidney incl …
Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-kappaB/p65 regulatory axis.
Lu Q, Ma Z, Ding Y, Bedarida T, Chen L, Xie Z, Song P, Zou MH. Lu Q, et al. Nat Commun. 2019 May 13;10(1):2145. doi: 10.1038/s41467-019-10116-0. Nat Commun. 2019. PMID: 31086184 Free PMC article.
We find that SNRK exerts anti-inflammatory effects by interacting with activated nuclear factor-kappaB (NF-kappaB)/p65. ...Together, our work identifies miR-103a-3p/SNRK/NF-kappaB/p65 as a regulatory axis of AngII-induced renal inflammation and fibrosis....
We find that SNRK exerts anti-inflammatory effects by interacting with activated nuclear factor-kappaB (NF-kappaB)/p65. ...Together, …
Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries.
Osman Y, Elsharkawy T, Hashim TM, Alratroot JA, Aljindan F, Almulla L, Alsuwat HS, Al Otaibi WM, Hegazi FM, Ibrahim AM, Borgio JF, AbdulAzeez S. Osman Y, et al. Int J Breast Cancer. 2022 Oct 11;2022:2442109. doi: 10.1155/2022/2442109. eCollection 2022. Int J Breast Cancer. 2022. PMID: 36268271 Free PMC article.
The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We …
The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of …
Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.
Gan RY, Li HB. Gan RY, et al. Int J Mol Sci. 2014 Sep 19;15(9):16698-718. doi: 10.3390/ijms150916698. Int J Mol Sci. 2014. PMID: 25244018 Free PMC article. Review.
Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated protein kinase (AMPK)-related protein kinases, and possesses versatile biological …
Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical cancer suppressor in many cancer …
Dusp-5 and Snrk-1 coordinately function during vascular development and disease.
Pramanik K, Chun CZ, Garnaas MK, Samant GV, Li K, Horswill MA, North PE, Ramchandran R. Pramanik K, et al. Blood. 2009 Jan 29;113(5):1184-91. doi: 10.1182/blood-2008-06-162180. Epub 2008 Oct 16. Blood. 2009. PMID: 18927432 Free PMC article.
Together, Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1. Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, im …
Together, Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snr …
Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment.
Nguyen K, Rivera A, Alzoubi M, Wathieu H, Dong S, Yousefi H, Matossian M, Alahari S, Drewry D, Burow M, Collins-Burow B. Nguyen K, et al. Oncotarget. 2021 May 25;12(11):1110-1115. doi: 10.18632/oncotarget.27929. eCollection 2021 May 25. Oncotarget. 2021. PMID: 34084284 Free PMC article. Review.
LKB1-signaling has prominent roles in cancer development and metastasis. This report evaluates LKB1-signaling pathway gene expression associations with patient survival in overall breast cancer, specific subtypes, as well as pre- and post-chemotherapy. ...Our findin …
LKB1-signaling has prominent roles in cancer development and metastasis. This report evaluates LKB1-signaling pathway gene expression …
17 results