Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 4
1994 6
1995 4
1996 6
1997 8
1998 3
1999 4
2000 6
2001 8
2002 15
2003 5
2004 9
2005 7
2006 9
2007 22
2008 27
2009 32
2010 35
2011 25
2012 35
2013 28
2014 33
2015 35
2016 46
2017 52
2018 44
2019 72
2020 52
2021 62
2022 72
2023 67
2024 29

Text availability

Article attribute

Article type

Publication date

Search Results

759 results

Results by year

Filters applied: . Clear all
Page 1
Noonan syndrome and clinically related disorders.
Tartaglia M, Gelb BD, Zenker M. Tartaglia M, et al. Best Pract Res Clin Endocrinol Metab. 2011 Feb;25(1):161-79. doi: 10.1016/j.beem.2010.09.002. Best Pract Res Clin Endocrinol Metab. 2011. PMID: 21396583 Free PMC article. Review.
Noonan syndrome is transmitted as an autosomal dominant trait, and is genetically heterogeneous. So far, heterozygous mutations in nine genes (PTPN11, SOS1, KRAS, NRAS, RAF1, BRAF, SHOC2, MEK1 and CBL) have been documented to underlie this disorder or clinically rel …
Noonan syndrome is transmitted as an autosomal dominant trait, and is genetically heterogeneous. So far, heterozygous mutations in nine g …
CycC1;1-WRKY75 complex-mediated transcriptional regulation of SOS1 controls salt stress tolerance in Arabidopsis.
Lu KK, Song RF, Guo JX, Zhang Y, Zuo JX, Chen HH, Liao CY, Hu XY, Ren F, Lu YT, Liu WC. Lu KK, et al. Plant Cell. 2023 Jun 26;35(7):2570-2591. doi: 10.1093/plcell/koad105. Plant Cell. 2023. PMID: 37040621 Free PMC article.
SALT OVERLY SENSITIVE1 (SOS1) is a key component of plant salt tolerance. However, how SOS1 transcription is dynamically regulated in plant response to different salinity conditions remains elusive. ...Enhanced salt tolerance of the cycc1;1 mutant was completely com …
SALT OVERLY SENSITIVE1 (SOS1) is a key component of plant salt tolerance. However, how SOS1 transcription is dynamically regul …
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B. Hillig RC, et al. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25. Proc Natl Acad Sci U S A. 2019. PMID: 30683722 Free PMC article.
Since the late 1980s, mutations in the RAS genes have been recognized as major oncogenes with a high occurrence rate in human cancers. ...The binding sites, mode of action, and selectivity were elucidated using crystal structures of KRAS(G12C)-SOS1, SOS1, and …
Since the late 1980s, mutations in the RAS genes have been recognized as major oncogenes with a high occurrence rate in human cancers …
Targeting RAS oncogenesis with SOS1 inhibitors.
Hillig RC, Bader B. Hillig RC, et al. Adv Cancer Res. 2022;153:169-203. doi: 10.1016/bs.acr.2021.07.001. Epub 2021 Sep 15. Adv Cancer Res. 2022. PMID: 35101230 Review.
As an alternative approach, inhibitors for the RAS guanine nucleotide exchange factor SOS1 have been investigated by several academic groups and companies, and major progress has been achieved in recent years in the optimization of small molecule activators and inhibitors …
As an alternative approach, inhibitors for the RAS guanine nucleotide exchange factor SOS1 have been investigated by several academic …
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules.
Tulpule A, Guan J, Neel DS, Allegakoen HR, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhija S, Huang B, Bivona TG. Tulpule A, et al. Cell. 2021 May 13;184(10):2649-2664.e18. doi: 10.1016/j.cell.2021.03.031. Epub 2021 Apr 12. Cell. 2021. PMID: 33848463 Free PMC article.
These pathogenic biomolecular condensates locally concentrate the RAS activating complex GRB2/SOS1 and activate RAS in a lipid membrane-independent manner. RTK protein granule formation is critical for oncogenic RAS/MAPK signaling output in these cells. ...
These pathogenic biomolecular condensates locally concentrate the RAS activating complex GRB2/SOS1 and activate RAS in a lipid membra …
Translational relevance of SOS1 targeting for KRAS-mutant colorectal cancer.
Alem D, Yang X, Beato F, Sarcar B, Tassielli AF, Dai R, Hogenson TL, Park MA, Jiang K, Cai J, Yuan Y, Fernandez-Zapico ME, Tan AC, Fleming JB, Xie H. Alem D, et al. Mol Carcinog. 2023 Jul;62(7):1025-1037. doi: 10.1002/mc.23543. Epub 2023 Apr 12. Mol Carcinog. 2023. PMID: 37042566
Finally, we showed that GTP-bound RAS level underwent rebound even in BI3406-sensitive PDOs with no change of KRAS downstream effector genes, thus suggesting upregulation of guanine nucleotide exchange factor as potential cellular adaptation mechanisms to SOS1 inhib …
Finally, we showed that GTP-bound RAS level underwent rebound even in BI3406-sensitive PDOs with no change of KRAS downstream effector ge …
SOS1 gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population: Results from a nested case-control study in Taiyuan, China.
Chen Q, Yang H, Feng Y, Zhang P, Wu W, Li S, Thompson B, Wang X, Peng T, Wang F, Xie B, Guo P, Li M, Wang Y, Zhao N, Wang S, Zhang Y. Chen Q, et al. Diab Vasc Dis Res. 2018 Mar;15(2):158-161. doi: 10.1177/1479164117745260. Epub 2017 Dec 13. Diab Vasc Dis Res. 2018. PMID: 29233017 Free article.
At the gene level, SOS1 was statistically significantly associated with gestational diabetes mellitus risk after adjusting for multiple comparisons. Moreover, AGGA and GGGG haplotypes in SOS1 gene were associated with reduced risk of gestational diabet …
At the gene level, SOS1 was statistically significantly associated with gestational diabetes mellitus risk after adjusting for …
SOS1 and halophytism.
Oh DH, Zahir A, Yun DJ, Bressan RA, Bohnert HJ. Oh DH, et al. Plant Signal Behav. 2009 Nov;4(11):1081-3. doi: 10.4161/psb.4.11.9786. Epub 2009 Nov 11. Plant Signal Behav. 2009. PMID: 19838069 Free PMC article.
Much is already known about the function and functioning of the three genes that make up the SOS (Salt-Overly-Sensitive) pathway in plants, but recent studies indicate that the linkage between external increases in salinity and stress protection provided by genes …
Much is already known about the function and functioning of the three genes that make up the SOS (Salt-Overly-Sensitive) pathway in p …
Noonan syndrome patient-specific induced cardiomyocyte model carrying SOS1 gene variant c.1654A>G.
Gurusamy N, Rajasingh S, Sigamani V, Rajasingh R, Isai DG, Czirok A, Bittel D, Rajasingh J. Gurusamy N, et al. Exp Cell Res. 2021 Mar 1;400(1):112508. doi: 10.1016/j.yexcr.2021.112508. Epub 2021 Feb 4. Exp Cell Res. 2021. PMID: 33549576 Free PMC article.
NS associated with the Son of Sevenless homolog 1 (SOS1) gene mutation attributes to the development of cardiomyopathy and congenital heart defects. ...We report for the first time that NS-iPSCs carry a single nucleotide variation in the SOS1 gene at t …
NS associated with the Son of Sevenless homolog 1 (SOS1) gene mutation attributes to the development of cardiomyopathy and con …
SOS1 gene overexpression increased salt tolerance in transgenic tobacco by maintaining a higher K(+)/Na(+) ratio.
Yue Y, Zhang M, Zhang J, Duan L, Li Z. Yue Y, et al. J Plant Physiol. 2012 Feb 15;169(3):255-61. doi: 10.1016/j.jplph.2011.10.007. Epub 2011 Nov 23. J Plant Physiol. 2012. PMID: 22115741
Crop productivity is greatly affected by soil salinity, so improvement in salinity tolerance of crops is a major objective of many studies. We overexpressed the Arabidopsis thaliana SOS1 gene, which encodes a plasma membrane Na(+)/H(+) antiporter, in tobacco (Nicoti …
Crop productivity is greatly affected by soil salinity, so improvement in salinity tolerance of crops is a major objective of many studies. …
759 results