Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1997 1
1998 4
1999 1
2000 4
2001 1
2002 2
2003 9
2004 4
2005 13
2006 11
2007 32
2008 56
2009 93
2010 142
2011 186
2012 226
2013 296
2014 337
2015 390
2016 438
2017 402
2018 432
2019 469
2020 518
2021 462
2022 438
2023 395
2024 144

Text availability

Article attribute

Article type

Publication date

Search Results

4,872 results

Results by year

Filters applied: . Clear all
Page 1
SOX2 in development and cancer biology.
Novak D, Hüser L, Elton JJ, Umansky V, Altevogt P, Utikal J. Novak D, et al. Semin Cancer Biol. 2020 Dec;67(Pt 1):74-82. doi: 10.1016/j.semcancer.2019.08.007. Epub 2019 Aug 11. Semin Cancer Biol. 2020. PMID: 31412296 Free article. Review.
On the other hand, dysregulation of SOX2 expression is associated with a multitude of cancer types and it has been shown that SOX2 positively affects cancer cell traits such as the capacity to proliferate, migrate, invade and metastasize. Moreover, the …
On the other hand, dysregulation of SOX2 expression is associated with a multitude of cancer types and it has been shown that …
TM4SF1 promotes EMT and cancer stemness via the Wnt/beta-catenin/SOX2 pathway in colorectal cancer.
Tang Q, Chen J, Di Z, Yuan W, Zhou Z, Liu Z, Han S, Liu Y, Ying G, Shu X, Di M. Tang Q, et al. J Exp Clin Cancer Res. 2020 Nov 5;39(1):232. doi: 10.1186/s13046-020-01690-z. J Exp Clin Cancer Res. 2020. PMID: 33153498 Free PMC article.
BACKGROUND: Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and is closely associated with poor prognosis. However, the role of TM4SF1 and its potential mechanism in colorectal cancer (CRC) remain elusive. ...CONCLUSION: O …
BACKGROUND: Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and is closely associated wit …
MicroRNAs regulating SOX2 in cancer progression and therapy response.
Mirzaei S, Saebfar H, Gholami MH, Hashemi F, Zarrabi A, Zabolian A, Entezari M, Hushmandi K, Samarghandian S, Aref AR, Ashrafizadeh M, Khan H. Mirzaei S, et al. Expert Rev Mol Med. 2021 Sep 29;23:e13. doi: 10.1017/erm.2021.15. Expert Rev Mol Med. 2021. PMID: 34583803 Review.
The lncRNAs and circRNAs can function as upstream mediators of miRNA/SOX2 axis in cancers. In addition, NF-kappaB, TNF-alpha and SOX17 are among other molecular pathways regulating miRNA/SOX2 axis in cancer. Noteworthy, anti-cancer compounds inc …
The lncRNAs and circRNAs can function as upstream mediators of miRNA/SOX2 axis in cancers. In addition, NF-kappaB, TNF-alpha a …
SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial-mesenchymal transition by beta-catenin and Beclin1/autophagy signaling in colorectal cancer.
Zhu Y, Huang S, Chen S, Chen J, Wang Z, Wang Y, Zheng H. Zhu Y, et al. Cell Death Dis. 2021 May 5;12(5):449. doi: 10.1038/s41419-021-03733-5. Cell Death Dis. 2021. PMID: 33953166 Free PMC article.
Sex-determining region Y-box2 (SOX2), a master regulator of embryonic and induced pluripotent stem cells, drives cancer stem cells (CSCs) properties, fuels tumor initiation, and contributes to tumor aggressiveness. Our previous study has demonstrated the oncogenic r …
Sex-determining region Y-box2 (SOX2), a master regulator of embryonic and induced pluripotent stem cells, drives cancer stem c …
The dark side of SOX2: cancer - a comprehensive overview.
Wuebben EL, Rizzino A. Wuebben EL, et al. Oncotarget. 2017 Jul 4;8(27):44917-44943. doi: 10.18632/oncotarget.16570. Oncotarget. 2017. PMID: 28388544 Free PMC article. Review.
Over the past 10 years, SOX2 has been shown to be expressed in at least 25 different cancers. This review provides a comprehensive overview of the roles of SOX2 in cancer and focuses on two broad topics. The first delves into the expression and functio …
Over the past 10 years, SOX2 has been shown to be expressed in at least 25 different cancers. This review provides a comprehen …
Clinical and Biological Features of Neuroendocrine Prostate Cancer.
Yamada Y, Beltran H. Yamada Y, et al. Curr Oncol Rep. 2021 Jan 12;23(2):15. doi: 10.1007/s11912-020-01003-9. Curr Oncol Rep. 2021. PMID: 33433737 Free PMC article. Review.
PURPOSE OF REVIEW: Neuroendocrine prostate cancer (NEPC) is an aggressive histologic subtype of prostate cancer that most commonly arises in later stages of prostate cancer as a mechanism of treatment resistance. ...RECENT FINDINGS: NEPC can arise "de novo" b …
PURPOSE OF REVIEW: Neuroendocrine prostate cancer (NEPC) is an aggressive histologic subtype of prostate cancer that most comm …
Understanding the function and regulation of Sox2 for its therapeutic potential in breast cancer.
Dey A, Kundu M, Das S, Jena BC, Mandal M. Dey A, et al. Biochim Biophys Acta Rev Cancer. 2022 Mar;1877(2):188692. doi: 10.1016/j.bbcan.2022.188692. Epub 2022 Feb 2. Biochim Biophys Acta Rev Cancer. 2022. PMID: 35122882 Review.
Sox family of transcriptional factors play essential functions in development and are implicated in multiple clinical disorders, including cancer. Sox2 being their most prominent member and performing a critical role in reprogramming differentiated adult cells to an …
Sox family of transcriptional factors play essential functions in development and are implicated in multiple clinical disorders, including …
ANGPTL1, Foxo3a-Sox2, and colorectal cancer metastasis.
Jiang K, Chen H, Ding K. Jiang K, et al. Clin Sci (Lond). 2022 Sep 30;136(18):1367-1370. doi: 10.1042/CS20220394. Clin Sci (Lond). 2022. PMID: 36156125 Free PMC article.
In the present commentary, we discuss new observations stating that angiopoietin-like protein 1 (ANGPTL1) attenuates cancer metastasis and stemness through Forkhead box O-3a (Foxo3a)-SRY-related HMG-box-2 (Sox2) axis in colorectal cancer (Clin. ...Here, we in …
In the present commentary, we discuss new observations stating that angiopoietin-like protein 1 (ANGPTL1) attenuates cancer metastasi …
LncRNA PCAT1 activates SOX2 and suppresses radioimmune responses via regulating cGAS/STING signalling in non-small cell lung cancer.
Gao Y, Zhang N, Zeng Z, Wu Q, Jiang X, Li S, Sun W, Zhang J, Li Y, Li J, He F, Huang Z, Zhang J, Gong Y, Xie C. Gao Y, et al. Clin Transl Med. 2022 Apr;12(4):e792. doi: 10.1002/ctm2.792. Clin Transl Med. 2022. PMID: 35415876 Free PMC article.
BACKGROUND: The expression of long non-coding RNA (lncRNA) prostate cancer-associated ncRNA transcripts 1 (PCAT1) is increased in non-small cell lung cancer (NSCLC). ...PCAT1 knockdown restrained proliferation, increased apoptosis, and repressed cell metastasis in v …
BACKGROUND: The expression of long non-coding RNA (lncRNA) prostate cancer-associated ncRNA transcripts 1 (PCAT1) is increased in non …
SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond.
Schaefer T, Lengerke C. Schaefer T, et al. Oncogene. 2020 Jan;39(2):278-292. doi: 10.1038/s41388-019-0997-x. Epub 2019 Sep 2. Oncogene. 2020. PMID: 31477842 Free PMC article. Review.
Research of the past view years expanded our understanding of the various physiological functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis, reprogramming, and cancer. However, while scientific reports featuring novel and exciting asp …
Research of the past view years expanded our understanding of the various physiological functions the cell-fate determining transcription fa …
4,872 results