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1993 1
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1,458 results

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Page 1
SOX9: An emerging driving factor from cancer progression to drug resistance.
Panda M, Tripathi SK, Biswal BK. Panda M, et al. Biochim Biophys Acta Rev Cancer. 2021 Apr;1875(2):188517. doi: 10.1016/j.bbcan.2021.188517. Epub 2021 Jan 29. Biochim Biophys Acta Rev Cancer. 2021. PMID: 33524528 Review.
Interestingly, SOX9 acts as a proto-oncogene or tumor suppressor gene, relying upon kinds of cancer. ...However, the link between SOX9 and cancer drug resistance has only recently been discovered. ...
Interestingly, SOX9 acts as a proto-oncogene or tumor suppressor gene, relying upon kinds of cancer. ...However, the link betw …
SOX9: The master regulator of cell fate in breast cancer.
Jana S, Madhu Krishna B, Singhal J, Horne D, Awasthi S, Salgia R, Singhal SS. Jana S, et al. Biochem Pharmacol. 2020 Apr;174:113789. doi: 10.1016/j.bcp.2019.113789. Epub 2020 Jan 3. Biochem Pharmacol. 2020. PMID: 31911091 Free PMC article. Review.
SOX9 overexpression is a frequent event in breast cancer (BC) subtypes. ...The focus of this review is to appraise recent advances regarding the involvement of SOX9 in BC pathogenesis. First, we provide a general overview of SOX9 structure and function …
SOX9 overexpression is a frequent event in breast cancer (BC) subtypes. ...The focus of this review is to appraise recent adva …
CD73 sustained cancer-stem-cell traits by promoting SOX9 expression and stability in hepatocellular carcinoma.
Ma XL, Hu B, Tang WG, Xie SH, Ren N, Guo L, Lu RQ. Ma XL, et al. J Hematol Oncol. 2020 Feb 5;13(1):11. doi: 10.1186/s13045-020-0845-z. J Hematol Oncol. 2020. PMID: 32024555 Free PMC article.
Mechanistically, CD73 exerted its pro-stemness activity through dual AKT-dependent mechanisms: activating SOX9 transcription via c-Myc, and preventing SOX9 degradation by inhibiting glycogen synthase kinase 3beta. Clinically, the combined analysis of CD73 and SOX …
Mechanistically, CD73 exerted its pro-stemness activity through dual AKT-dependent mechanisms: activating SOX9 transcription via c-My …
Interplay between SOX9 transcription factor and microRNAs in cancer.
Ashrafizadeh M, Zarrabi A, Orouei S, Zabolian A, Saleki H, Azami N, Bejandi AK, Mirzaei S, Janaghard MN, Hushmandi K, Nabavi N, Baradaran B, Kumar AP, Makvandi P, Samarghandian S, Khan H, Hamblin MR. Ashrafizadeh M, et al. Int J Biol Macromol. 2021 Jul 31;183:681-694. doi: 10.1016/j.ijbiomac.2021.04.185. Epub 2021 May 3. Int J Biol Macromol. 2021. PMID: 33957202 Review.
Since miRNAs can affect differentiation, migration, proliferation and other physiological mechanisms, disturbances in their expression have been associated with cancer development. In this review, we evaluate the relationship between miRNAs and SOX9 in different …
Since miRNAs can affect differentiation, migration, proliferation and other physiological mechanisms, disturbances in their expression have …
An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer.
Liang X, Duronio GN, Yang Y, Bala P, Hebbar P, Spisak S, Sahgal P, Singh H, Zhang Y, Xie Y, Cejas P, Long HW, Bass AJ, Sethi NS. Liang X, et al. Gastroenterology. 2022 Jan;162(1):209-222. doi: 10.1053/j.gastro.2021.09.044. Epub 2021 Sep 25. Gastroenterology. 2022. PMID: 34571027 Free PMC article.
Disrupting SOX9 activity impairs primary CRC tumor growth by inducing intestinal differentiation. ...SOX9 up-regulates PROM1 via a Wnt-responsive intronic enhancer. A pentaspan transmembrane protein, PROM1 uses its first intracellular domain to support stem cell sig …
Disrupting SOX9 activity impairs primary CRC tumor growth by inducing intestinal differentiation. ...SOX9 up-regulates PROM1 v …
Regenerative lineages and immune-mediated pruning in lung cancer metastasis.
Laughney AM, Hu J, Campbell NR, Bakhoum SF, Setty M, Lavallée VP, Xie Y, Masilionis I, Carr AJ, Kottapalli S, Allaj V, Mattar M, Rekhtman N, Xavier JB, Mazutis L, Poirier JT, Rudin CM, Pe'er D, Massagué J. Laughney AM, et al. Nat Med. 2020 Feb;26(2):259-269. doi: 10.1038/s41591-019-0750-6. Epub 2020 Feb 10. Nat Med. 2020. PMID: 32042191 Free PMC article.
Developmental processes underlying normal tissue regeneration have been implicated in cancer, but the degree of their enactment during tumor progression and under the selective pressures of immune surveillance, remain unknown. ...In contrast, metastases are enriched for ke …
Developmental processes underlying normal tissue regeneration have been implicated in cancer, but the degree of their enactment durin …
Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment.
Fan Y, Li Y, Yao X, Jin J, Scott A, Liu B, Wang S, Huo L, Wang Y, Wang R, Pool Pizzi M, Ma L, Shao S, Sewastjanow-Silva M, Waters R, Chatterjee D, Liu B, Shanbhag N, Peng G, Calin GA, Mazur PK, Hanash SM, Ishizawa J, Hirata Y, Nagano O, Wang Z, Wang L, Xian W, McKeon F, Ajani JA, Song S. Fan Y, et al. Gut. 2023 Apr;72(4):624-637. doi: 10.1136/gutjnl-2021-326581. Epub 2022 Aug 24. Gut. 2023. PMID: 36002248
Here, we aim to dissect the role of SOX9-mediated cancer stemness attributes and immunosuppressive microenvironment in advanced gastric adenocarcinoma (GAC) for novel therapeutic discoveries. ...Cotargeting LIF/LIFR and CSF1R has great potential in targeting SOX9 …
Here, we aim to dissect the role of SOX9-mediated cancer stemness attributes and immunosuppressive microenvironment in advance …
Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis.
Liu Y, Zhuo S, Zhou Y, Ma L, Sun Z, Wu X, Wang XW, Gao B, Yang Y. Liu Y, et al. J Hepatol. 2022 Mar;76(3):652-664. doi: 10.1016/j.jhep.2021.11.010. Epub 2021 Nov 15. J Hepatol. 2022. PMID: 34793870 Free PMC article.
METHODS: To evaluate the function of Sox9 in YAP-induced hepatocarcinogenesis in vivo, we used several genetic mouse models of inducible hepatocyte-specific YAP activation with simultaneous Sox9 removal. ...We also found that human YAP and SOX9 may play simil …
METHODS: To evaluate the function of Sox9 in YAP-induced hepatocarcinogenesis in vivo, we used several genetic mouse models of induci …
SOX9 as an emerging target for anticancer drugs and a prognostic biomarker for cancer drug resistance.
Tripathi SK, Sahoo RK, Biswal BK. Tripathi SK, et al. Drug Discov Today. 2022 Sep;27(9):2541-2550. doi: 10.1016/j.drudis.2022.05.022. Epub 2022 May 27. Drug Discov Today. 2022. PMID: 35636723 Review.
Differential expression of SOX9 has been positively correlated with cancer cell growth, invasion, migration, metastasis, and therapy resistance. ...Therefore, in this review, we summarize current research focusing on SOX9 as a cancer therapeutic target …
Differential expression of SOX9 has been positively correlated with cancer cell growth, invasion, migration, metastasis, and t …
Therapeutic relevance of SOX9 stem cell factor in gastric cancer.
Carrasco-Garcia E, Álvarez-Satta M, García-Puga M, Ribeiro ML, Arevalo S, Arauzo-Bravo M, Matheu A. Carrasco-Garcia E, et al. Expert Opin Ther Targets. 2019 Feb;23(2):143-152. doi: 10.1080/14728222.2019.1559826. Epub 2018 Dec 20. Expert Opin Ther Targets. 2019. PMID: 30572738 Review.
Recent comprehensive genetic and molecular profiling has identified molecular subtypes of gastric cancer (GC) and has linked them to clinical information. Moreover, SOX9 has been recently described as a relevant regulator of the population of GC stem cells (gCSCs), …
Recent comprehensive genetic and molecular profiling has identified molecular subtypes of gastric cancer (GC) and has linked them to …
1,458 results