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Did you mean sen cancer (36,925 results)?
Pan-cancer analysis identifies SPEN mutation as a predictive biomarker with the efficacy of immunotherapy.
Li YD, Huang H, Ren ZJ, Yuan Y, Wu H, Liu C. Li YD, et al. BMC Cancer. 2023 Aug 24;23(1):793. doi: 10.1186/s12885-023-11235-0. BMC Cancer. 2023. PMID: 37620924 Free PMC article.
Thus, we firstly analyzed the potential role of SPEN in the TCGA pan-cancer cohort and clinical samples. Bioinformatics analysis and immunohistochemistry (IHC) staining confirm that the expression of SPEN is significantly different in various cancers a …
Thus, we firstly analyzed the potential role of SPEN in the TCGA pan-cancer cohort and clinical samples. Bioinformatics analys …
The long tail of oncogenic drivers in prostate cancer.
Armenia J, Wankowicz SAM, Liu D, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, Montgomery B, Pritchard C, Morrissey C, Barbieri CE, Beltran H, Sboner A, Zafeiriou Z, Miranda S, Bielski CM, Penson AV, Tolonen C, Huang FW, Robinson D, Wu YM, Lonigro R, Garraway LA, Demichelis F, Kantoff PW, Taplin ME, Abida W, Taylor BS, Scher HI, Nelson PS, de Bono JS, Rubin MA, Sawyers CL, Chinnaiyan AM; PCF/SU2C International Prostate Cancer Dream Team; Schultz N, Van Allen EM. Armenia J, et al. Nat Genet. 2018 May;50(5):645-651. doi: 10.1038/s41588-018-0078-z. Epub 2018 Apr 2. Nat Genet. 2018. PMID: 29610475 Free PMC article.
Here we aggregate and uniformly analyze exome sequencing data from 1,013 prostate cancers. We identify and validate a new class of E26 transformation-specific (ETS)-fusion-negative tumors defined by mutations in epigenetic regulators, as well as alterations in pathways not …
Here we aggregate and uniformly analyze exome sequencing data from 1,013 prostate cancers. We identify and validate a new class of E2 …
SPEN, a new player in primary cilia formation and cell migration in breast cancer.
Légaré S, Chabot C, Basik M. Légaré S, et al. Breast Cancer Res. 2017 Sep 6;19(1):104. doi: 10.1186/s13058-017-0897-3. Breast Cancer Res. 2017. PMID: 28877752 Free PMC article.
METHODS: We determined the hormone-independent transcriptional program regulated by the ERalpha cofactor SPEN in breast cancer using DNA microarrays. The biological functions regulated by SPEN independently of hormones were studied in vitro in ERalpha-positiv …
METHODS: We determined the hormone-independent transcriptional program regulated by the ERalpha cofactor SPEN in breast cancer …
Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress.
Yang ZY, Yan XC, Zhang JY, Liang L, Gao CC, Zhang PR, Liu Y, Sun JX, Ruan B, Duan JL, Wang RN, Feng XX, Che B, Xiao T, Han H. Yang ZY, et al. J Clin Invest. 2023 Oct 16;133(20):e159860. doi: 10.1172/JCI159860. J Clin Invest. 2023. PMID: 37607001 Free PMC article.
In human cancer biopsies, a low endothelial SPEN level correlated with extended overall survival. ...Together, these results demonstrate that SPEN is required for angiogenesis by repressing pRNA to enable rRNA gene transcription and ribosomal biogenesis and t …
In human cancer biopsies, a low endothelial SPEN level correlated with extended overall survival. ...Together, these results d …
Systematic discovery of Xist RNA binding proteins.
Chu C, Zhang QC, da Rocha ST, Flynn RA, Bharadwaj M, Calabrese JM, Magnuson T, Heard E, Chang HY. Chu C, et al. Cell. 2015 Apr 9;161(2):404-16. doi: 10.1016/j.cell.2015.03.025. Epub 2015 Apr 2. Cell. 2015. PMID: 25843628 Free PMC article.
Specific interactors include HnrnpK, which participates in Xist-mediated gene silencing and histone modifications but not Xist localization, and Drosophila Split ends homolog Spen, which interacts via the A-repeat domain of Xist and is required for gene silencing. ...
Specific interactors include HnrnpK, which participates in Xist-mediated gene silencing and histone modifications but not Xist localization, …
SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma.
Li Y, Lv Y, Cheng C, Huang Y, Yang L, He J, Tao X, Hu Y, Ma Y, Su Y, Wu L, Yu G, Jiang Q, Liu S, Liu X, Liu Z. Li Y, et al. Cell Death Dis. 2020 Jul 2;11(7):509. doi: 10.1038/s41419-020-2699-2. Cell Death Dis. 2020. PMID: 32641685 Free PMC article.
SPEN family transcriptional repressor (SPEN), also known as the SMART/HDAC1-associated repressor protein (SHARP), has been reported to modulate the malignant phenotypes of breast cancer, colon cancer, and ovarian cancer. ...Elevated SPEN …
SPEN family transcriptional repressor (SPEN), also known as the SMART/HDAC1-associated repressor protein (SHARP), has been rep …
SPEN is required for Xist upregulation during initiation of X chromosome inactivation.
Robert-Finestra T, Tan BF, Mira-Bontenbal H, Timmers E, Gontan C, Merzouk S, Giaimo BD, Dossin F, van IJcken WFJ, Martens JWM, Borggrefe T, Heard E, Gribnau J. Robert-Finestra T, et al. Nat Commun. 2021 Dec 1;12(1):7000. doi: 10.1038/s41467-021-27294-5. Nat Commun. 2021. PMID: 34853312 Free PMC article.
Here, we show that SPEN plays an important role in initiation of XCI. Spen null female mouse embryonic stem cells (ESCs) are defective in Xist upregulation upon differentiation. We find that Xist-mediated SPEN recruitment to the Xi chromosome happens very ear …
Here, we show that SPEN plays an important role in initiation of XCI. Spen null female mouse embryonic stem cells (ESCs) are d …
Chromatin Regulator SPEN/SHARP in X Inactivation and Disease.
Giaimo BD, Robert-Finestra T, Oswald F, Gribnau J, Borggrefe T. Giaimo BD, et al. Cancers (Basel). 2021 Apr 1;13(7):1665. doi: 10.3390/cancers13071665. Cancers (Basel). 2021. PMID: 33916248 Free PMC article. Review.
The specificity factor for this process is the long non-coding RNA Xinactivespecifictranscript (Xist), which is upregulated from one X chromosome in female cells. Subsequently, Xist is bound by the corepressor SHARP/SPEN, recruiting and/or activating histone deacetylases ( …
The specificity factor for this process is the long non-coding RNA Xinactivespecifictranscript (Xist), which is upregulated from one X chrom …
An autonomous metabolic role for Spen.
Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T. Hazegh KE, et al. PLoS Genet. 2017 Jun 22;13(6):e1006859. doi: 10.1371/journal.pgen.1006859. eCollection 2017 Jun. PLoS Genet. 2017. PMID: 28640815 Free PMC article.
Spenito, a small Spen family member, counteracted Spen function in fat regulation. ...This study demonstrates that Spen is a key regulator of energy balance and provides a molecular context to understand the metabolic defects that arise from Spen dysfu …
Spenito, a small Spen family member, counteracted Spen function in fat regulation. ...This study demonstrates that Spen …
Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis.
Hill HA, Qi X, Jain P, Nomie K, Wang Y, Zhou S, Wang ML. Hill HA, et al. Blood Adv. 2020 Jul 14;4(13):2927-2938. doi: 10.1182/bloodadvances.2019001350. Blood Adv. 2020. PMID: 32598477 Free PMC article.
The genes with the highest mutational frequency difference (>5%) are TP53, ATM, KMT2A, MAP3K14, BTK, TRAF2, CHD2, TLR2, ARID2, RIMS2, NOTCH2, TET2, SPEN, NSD2, CARD11, CCND1, SP140, CDKN2A, and S1PR1. These findings provide a summary of the mutational landscape of MCL. …
The genes with the highest mutational frequency difference (>5%) are TP53, ATM, KMT2A, MAP3K14, BTK, TRAF2, CHD2, TLR2, ARID2, RIMS2, NOT …
143 results