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103 results

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Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB.
Ding M, Li Q, Tan X, Zhang L, Tan J, Zheng L. Ding M, et al. Aging (Albany NY). 2022 Aug 14;14(15):6338-6357. doi: 10.18632/aging.204225. Epub 2022 Aug 14. Aging (Albany NY). 2022. PMID: 35969172 Free PMC article.
However, no study has hitherto conducted a systematic pan-cancer analysis on SPIB. Herein, we analyzed the differential expression of SPIB in pan-cancer using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases and fou …
However, no study has hitherto conducted a systematic pan-cancer analysis on SPIB. Herein, we analyzed the differential expres …
SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.
Gu W, Qi G, Chen L. Gu W, et al. Iran J Immunol. 2023 Sep 1;20(3):335-347. doi: 10.22034/iji.2023.98236.2559. Iran J Immunol. 2023. PMID: 37452634 Free article.
OBJECTIVE: To investigate the functions and mechanisms of SPIB in ovarian cancer (OC) cells. METHODS: Cell proliferation, apoptosis, migration, and invasion were determined using colony formation, EdU, flow cytometry, and transwell assays, respectively. ...SPIB …
OBJECTIVE: To investigate the functions and mechanisms of SPIB in ovarian cancer (OC) cells. METHODS: Cell proliferation, apop …
Therapeutic targeting of SPIB/SPI1-facilitated interplay of cancer cells and neutrophils inhibits aerobic glycolysis and cancer progression.
Wang J, Wang X, Guo Y, Ye L, Li D, Hu A, Cai S, Yuan B, Jin S, Zhou Y, Li Q, Zheng L, Tong Q. Wang J, et al. Clin Transl Med. 2021 Nov;11(11):e588. doi: 10.1002/ctm2.588. Clin Transl Med. 2021. PMID: 34841706 Free PMC article.
Upregulation of SPI1 or SPIB was found to be associated with poor prognosis in patients suffering from colon cancer. CONCLUSIONS: Therapeutic targeting of SPIB/SPI1-facilitated interplay of cancerous cells and neutrophils suppresses aerobic glycolysis …
Upregulation of SPI1 or SPIB was found to be associated with poor prognosis in patients suffering from colon cancer. CONCLUSIO …
SPIB promotes anoikis resistance via elevated autolysosomal process in lung cancer cells.
Zhang H, Wang G, Zhou R, Li X, Sun Y, Li Y, Du W, Yan X, Yang J, Chang X, Liu Z, Ma Z. Zhang H, et al. FEBS J. 2020 Nov;287(21):4696-4709. doi: 10.1111/febs.15272. Epub 2020 Mar 24. FEBS J. 2020. PMID: 32129936 Free article.
However, the intersection of these two cellular responses in lung cancer cells has not been extensively studied. Here, we identified that upon matrix deprivation, the lymphocyte lineage-specific Ets transcription factor SPIB was activated and directly enhanced SNAP4 …
However, the intersection of these two cellular responses in lung cancer cells has not been extensively studied. Here, we identified …
SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells.
Zhao X, Li L, Yuan S, Zhang Q, Jiang X, Luo T. Zhao X, et al. Cell Signal. 2021 Dec;88:110148. doi: 10.1016/j.cellsig.2021.110148. Epub 2021 Sep 14. Cell Signal. 2021. PMID: 34530056
Previous studies have shown that the expression of SPIB is downregulated in human colorectal cancer tissues. The purpose of our study was to explore the biological function and related mechanism of SPIB in colorectal cancer cells. ...After silencing MA …
Previous studies have shown that the expression of SPIB is downregulated in human colorectal cancer tissues. The purpose of ou …
A co-regulatory network of SPIB, AQP8, and GUCA2B related to immune infiltration for early-stage colorectal cancer in silico and in vitro.
Hu JM, Liu PY, Chen YC, Lin WZ, Chou YC, Tsai WC, Chu CM, Wu CC, Chang YT. Hu JM, et al. Am J Cancer Res. 2023 Nov 15;13(11):5271-5288. eCollection 2023. Am J Cancer Res. 2023. PMID: 38058807 Free PMC article.
In early-stage colorectal cancer (CRC), AQP8, GUCA2B, and SPIB were important suppressor genes and frequently co-expressed. ...In clinical CRC tissues, SPIB, AQP8, and GUCA2B were barely expressed compared to normal mucosa. ...
In early-stage colorectal cancer (CRC), AQP8, GUCA2B, and SPIB were important suppressor genes and frequently co-expressed. .. …
A novel super-enhancer-related gene signature predicts prognosis and immune microenvironment for breast cancer.
Wu Q, Tao X, Luo Y, Zheng S, Lin N, Xie X. Wu Q, et al. BMC Cancer. 2023 Aug 18;23(1):776. doi: 10.1186/s12885-023-11241-2. BMC Cancer. 2023. PMID: 37596527 Free PMC article. Clinical Trial.
BACKGROUND: This study targeted at developing a robust, prognostic signature based on super-enhancer-related genes (SERGs) to reveal survival prognosis and immune microenvironment of breast cancer. METHODS: RNA-sequencing data of breast cancer were retrieved from Th …
BACKGROUND: This study targeted at developing a robust, prognostic signature based on super-enhancer-related genes (SERGs) to reveal surviva …
SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells.
Horiuchi S, Koike T, Takebuchi H, Hoshino K, Sasaki I, Fukuda-Ohta Y, Kaisho T, Kitamura D. Horiuchi S, et al. Front Immunol. 2023 Oct 27;14:1250719. doi: 10.3389/fimmu.2023.1250719. eCollection 2023. Front Immunol. 2023. PMID: 37965309 Free PMC article.
Further analysis in IgG1(+) cell-specific SpiB conditional knockout (cKO) mice showed that function of SpiB is critical for the generation of late memory B cells but not early memory B cells or GC B cells. ...We further revealed that SpiB upregulates anti-apo …
Further analysis in IgG1(+) cell-specific SpiB conditional knockout (cKO) mice showed that function of SpiB is critical for th …
A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity.
Alexandre YO, Schienstock D, Lee HJ, Gandolfo LC, Williams CG, Devi S, Pal B, Groom JR, Cao W, Christo SN, Gordon CL, Starkey G, D'Costa R, Mackay LK, Haque A, Ludewig B, Belz GT, Mueller SN. Alexandre YO, et al. Sci Immunol. 2022 Jan 7;7(67):eabj0641. doi: 10.1126/sciimmunol.abj0641. Epub 2022 Jan 7. Sci Immunol. 2022. PMID: 34995096
We found analogous fibroblastic stromal cell diversity in the human spleen. In addition, we identify the transcription factor SpiB as a critical regulator required to support white pulp FRC differentiation, homeostatic chemokine expression, and antiviral T cell responses. …
We found analogous fibroblastic stromal cell diversity in the human spleen. In addition, we identify the transcription factor SpiB as …
SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.
Jin J, Du X, Zhou L, Yao D, Zou Q. Jin J, et al. J Obstet Gynaecol Res. 2022 Sep;48(9):2419-2430. doi: 10.1111/jog.15336. Epub 2022 Jun 30. J Obstet Gynaecol Res. 2022. PMID: 35770729
AIM: The functions and molecular mechanisms of SPI1-related protein (SPIB) were examined in cervical cancer (CC) cells. METHODS: Genes related to miscarriage and prognosis in CC were identified by Kaplan-Meier and differential expression analysis, respectively. ...H …
AIM: The functions and molecular mechanisms of SPI1-related protein (SPIB) were examined in cervical cancer (CC) cells. METHOD …
103 results