Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 1
2009 3
2010 3
2011 2
2012 3
2013 3
2014 4
2015 2
2016 2
2017 4
2018 4
2019 5
2020 2
2021 3
2022 1
2023 5
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

44 results

Results by year

Filters applied: . Clear all
Page 1
Role of SSH1 in colorectal cancer prognosis and tumor progression.
Song X, Xie D, Xia X, Tan F, Pei Q, Li Y, Zhou Z, Zhou Y, Li C, Wang K, Pei H. Song X, et al. J Gastroenterol Hepatol. 2020 Jul;35(7):1180-1188. doi: 10.1111/jgh.15001. Epub 2020 Feb 14. J Gastroenterol Hepatol. 2020. PMID: 32020663
Here, we evaluated the role of SSH1 in colorectal cancer (CRC) development and its prognostic value in patients with CRC. ...RESULTS: SSH1 expression was upregulated in cancer tissue compared with paired non-cancerous tissue in patients with CRC …
Here, we evaluated the role of SSH1 in colorectal cancer (CRC) development and its prognostic value in patients with CRC. ...R …
SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis.
Maimaiti Y, Maimaitiming M, Li Y, Aibibula S, Ainiwaer A, Aili A, Sun Z, Abudureyimu K. Maimaiti Y, et al. BMC Gastroenterol. 2018 Jan 16;18(1):12. doi: 10.1186/s12876-018-0739-5. BMC Gastroenterol. 2018. PMID: 29338701 Free PMC article.
CONCLUSIONS: SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis. SSH1 may play an important role in the development of gastric cancer, and it is a promising target for prevention and/or treatment of gastric c …
CONCLUSIONS: SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis. SSH1 may play …
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis.
Chen F, Aye L, Yu L, Liu L, Liu Y, Lin Y, Gao D, Gao Q, Zhang S. Chen F, et al. Carcinogenesis. 2023 May 27;44(3):232-241. doi: 10.1093/carcin/bgad009. Carcinogenesis. 2023. PMID: 36857607
However, the underlying mechanisms of SSH1 in iCCA remain largely elusive. Here, the expression and clinical significance of SSH1 were assessed using the iCCA patient samples. The results showed that SSH1 was dramatically up-regulated in iCCA tissues and elev …
However, the underlying mechanisms of SSH1 in iCCA remain largely elusive. Here, the expression and clinical significance of SSH1 …
Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis.
Lai SW, Cheng YC, Huang WC, Yadav VK, Fong IH, Yeh CT, Yang CK, Lee WH, Chen MY. Lai SW, et al. Aging (Albany NY). 2023 Oct 13;15(20):11033-11051. doi: 10.18632/aging.205064. Epub 2023 Oct 13. Aging (Albany NY). 2023. PMID: 37837551 Free PMC article.
Its disruption is progressively linked with metabolic issues, oncogene triggers, and heightened cancer susceptibility. Research points to slingshot protein phosphatase 1 (SSH1), a modulator of cofilin-1 (CFL-1), as instrumental in the reformation of the actin cytosk …
Its disruption is progressively linked with metabolic issues, oncogene triggers, and heightened cancer susceptibility. Research point …
Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes.
Sousa-Squiavinato ACM, Vasconcelos RI, Gehren AS, Fernandes PV, de Oliveira IM, Boroni M, Morgado-Díaz JA. Sousa-Squiavinato ACM, et al. Cancer Cell Int. 2021 Jan 22;21(1):69. doi: 10.1186/s12935-021-01770-w. Cancer Cell Int. 2021. PMID: 33482809 Free PMC article.
BACKGROUND: Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1) and its modulators, LIMK1/SSH1, play …
BACKGROUND: Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequent …
Overexpression of SSH1 in gastric adenocarcinoma and its correlation with clinicopathological features.
Daryabari SS, Safaralizadeh R, Hosseinpourfeizi M, Moaddab Y, Shokouhi B. Daryabari SS, et al. J Gastrointest Oncol. 2018 Aug;9(4):728-733. doi: 10.21037/jgo.2018.03.09. J Gastrointest Oncol. 2018. PMID: 30151269 Free PMC article.
BACKGROUND: Gastric adenocarcinoma is known to be the fourth most common cancer type and the second cause of cancer-related deaths. Movement and invasion of cancer cells is one of the major characteristics of the cancer phenotype that various types of …
BACKGROUND: Gastric adenocarcinoma is known to be the fourth most common cancer type and the second cause of cancer-related de …
Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth.
Ramos-Alvarez I, Lee L, Jensen RT. Ramos-Alvarez I, et al. Front Physiol. 2023 Apr 17;14:1147572. doi: 10.3389/fphys.2023.1147572. eCollection 2023. Front Physiol. 2023. PMID: 37138671 Free PMC article.
In the pancreas it is important in islet insulin secretion, growth of pancreatic cancer cells and in pancreatitis. However, there are no studies on its role or activation in pancreatic acinar cells. ...Results: CCK (0.3 and 100 nM), TPA, carbachol, Bombesin, secretin and V …
In the pancreas it is important in islet insulin secretion, growth of pancreatic cancer cells and in pancreatitis. However, there are …
Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination.
Rademaker G, Costanza B, Pyr Dit Ruys S, Peiffer R, Agirman F, Maloujahmoum N, Vertommen D, Turtoi A, Bellahcène A, Castronovo V, Peulen O. Rademaker G, et al. Oncogenesis. 2022 Jul 26;11(1):42. doi: 10.1038/s41389-022-00416-4. Oncogenesis. 2022. PMID: 35882839 Free PMC article.
INTRODUCTION: Colorectal cancer remains a public health issue and most colon cancer patients succumb to the development of metastases. ...Thanks to immunoprecipitation experiments, we demonstrated that paladin, was interacting with SSH1, a phosphatase involve …
INTRODUCTION: Colorectal cancer remains a public health issue and most colon cancer patients succumb to the development of met …
LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance.
Aggelou H, Chadla P, Nikou S, Karteri S, Maroulis I, Kalofonos HP, Papadaki H, Bravou V. Aggelou H, et al. Virchows Arch. 2018 May;472(5):727-737. doi: 10.1007/s00428-018-2298-0. Epub 2018 Jan 19. Virchows Arch. 2018. PMID: 29352327
LIMKs and SSH promote cancer cell invasion and metastasis and represent novel anti-cancer targets. ...Active cofilin, LIMK1, LIMK2, and SSH1 also correlated with the EMT markers examined. In addition, immunofluorescence analysis showed increased expression of …
LIMKs and SSH promote cancer cell invasion and metastasis and represent novel anti-cancer targets. ...Active cofilin, LIMK1, L …
Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy.
Cai N, Cheng K, Ma Y, Liu S, Tao R, Li Y, Li D, Guo B, Jia W, Liang H, Zhao J, Xia L, Ding ZY, Chen J, Zhang W. Cai N, et al. Gut. 2024 May 10;73(6):985-999. doi: 10.1136/gutjnl-2023-331342. Gut. 2024. PMID: 38123979 Free PMC article.
The secretion of MMP9 from HCC mediated slingshot protein phosphatase 1 (SSH1) shedding from CD8(+) T cells, leading to the inhibition of C-X-C motif chemokine receptor 3 (CXCR3)-mediated intracellular of G protein-coupled receptors signalling. ...
The secretion of MMP9 from HCC mediated slingshot protein phosphatase 1 (SSH1) shedding from CD8(+) T cells, leading to the inhibitio …
44 results