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Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.
Zi Z, Zhang Z, Feng Q, Kim C, Wang XD, Scherer PE, Gao J, Levine B, Yu Y. Zi Z, et al. Nat Commun. 2022 Apr 1;13(1):1760. doi: 10.1038/s41467-022-29461-8. Nat Commun. 2022. PMID: 35365663 Free PMC article.
Knockout of STK11IP leads to a robust increase of autophagy flux. Dephosphorylation of STK11IP at Ser(404) represses the role of STK11IP as an autophagy inhibitor. Mechanistically, STK11IP binds to V-ATPase, and regulates the activity of V-ATPase. ...
Knockout of STK11IP leads to a robust increase of autophagy flux. Dephosphorylation of STK11IP at Ser(404) represses the role …
Typing tumors using pathways selected by somatic evolution.
Wang S, Ma J, Zhang W, Shen JP, Huang J, Peng J, Ideker T. Wang S, et al. Nat Commun. 2018 Oct 8;9(1):4159. doi: 10.1038/s41467-018-06464-y. Nat Commun. 2018. PMID: 30297789 Free PMC article.
These pathways are clinically prognostic and predictive, including the TP53-AXIN-ARHGEF17 combination in liver and CYLC2-STK11-STK11IP in lung cancer, which we validate in independent cohorts. This ESP framework substantially improves the definition of cancer …
These pathways are clinically prognostic and predictive, including the TP53-AXIN-ARHGEF17 combination in liver and CYLC2-STK11-STK11IP …
The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma.
Kirchner M, Kluck K, Brandt R, Volckmar AL, Penzel R, Kazdal D, Endris V, Neumann O, Seker-Cin H, Goldschmid H, Glade J, Allgäuer M, Kriegsmann M, Winter H, Muley T, Perner S, Frost N, Reck M, Fröhling S, Schirmacher P, Thomas M, Budczies J, Christopoulos P, Stenzinger A. Kirchner M, et al. ESMO Open. 2021 Oct;6(5):100253. doi: 10.1016/j.esmoop.2021.100253. Epub 2021 Sep 3. ESMO Open. 2021. PMID: 34487971 Free PMC article.
BACKGROUND: Targeted therapies have improved survival and quality of life for patients with non-small-cell lung cancer with actionable driver mutations. However, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 gene (HER2, also known as …
BACKGROUND: Targeted therapies have improved survival and quality of life for patients with non-small-cell lung cancer with actionabl …
Analysis of candidate genes expected to be essential for melanoma surviving.
Krivosheeva IA, Filatova AY, Moshkovskii SA, Baranova AV, Skoblov MY. Krivosheeva IA, et al. Cancer Cell Int. 2020 Oct 7;20:488. doi: 10.1186/s12935-020-01584-2. eCollection 2020. Cancer Cell Int. 2020. PMID: 33041669 Free PMC article.
INTRODUCTION: Cancers may be treated by selective targeting of the genes vital for their survival. ...Here we present the results of transient siRNA-mediated knockdown of the four of such genes, namely, UNC45A, STK11IP, RHPN2 and ZNFX1, in melanoma cell line A375, t …
INTRODUCTION: Cancers may be treated by selective targeting of the genes vital for their survival. ...Here we present the results of …
Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2.
Buchet-Poyau K, Mehenni H, Radhakrishna U, Antonarakis SE. Buchet-Poyau K, et al. Cytogenet Genome Res. 2002;97(3-4):171-8. doi: 10.1159/000066620. Cytogenet Genome Res. 2002. PMID: 12438709
Finally, we also excluded the recently identified STK11-interacting protein gene (STK11IP, alias LIP1) mapped in 2q36 as candidate for PJS in the PJS07 family, although this could be a good candidate in other non-STK11/LKB1 families....
Finally, we also excluded the recently identified STK11-interacting protein gene (STK11IP, alias LIP1) mapped in 2q36 as candidate fo …
Cell biology: a cellular choreographer.
Nelson WJ. Nelson WJ. Nature. 2004 Mar 4;428(6978):28-9. doi: 10.1038/428028a. Nature. 2004. PMID: 14999267 Free PMC article.
Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis.
Bhatt V, Khayati K, Hu ZS, Lee A, Kamran W, Su X, Guo JY. Bhatt V, et al. Genes Dev. 2019 Feb 1;33(3-4):150-165. doi: 10.1101/gad.320481.118. Epub 2019 Jan 28. Genes Dev. 2019. PMID: 30692209 Free PMC article.
Loss of tumor suppressor liver kinase B1 (LKB1) promotes cancer cell proliferation but also leads to decreased metabolic plasticity in dealing with energy crises. Autophagy is a protective process involving self-cannibalization to maintain cellular energy homeostasis durin …
Loss of tumor suppressor liver kinase B1 (LKB1) promotes cancer cell proliferation but also leads to decreased metabolic plasticity i …
Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity.
Pehkonen H, Filippou A, Väänänen J, Lindfors I, Vänttinen M, Ianevski P, Mäkelä A, Munne P, Klefström J, Toppila-Salmi S, Grénman R, Hagström J, Mäkitie AA, Karhemo PR, Monni O. Pehkonen H, et al. Mol Oncol. 2024 Mar;18(3):662-676. doi: 10.1002/1878-0261.13593. Epub 2024 Jan 24. Mol Oncol. 2024. PMID: 38264964 Free PMC article.
Liprin-alpha1 localizes to adhesive and invasive structures in the periphery of cancer cells, where it modulates migration and invasion in head and neck squamous cell carcinoma (HNSCC) and breast cancer. ...Our data suggest that liprin-alpha1 is an important contrib …
Liprin-alpha1 localizes to adhesive and invasive structures in the periphery of cancer cells, where it modulates migration and invasi …
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas.
Takeda H, Miyoshi H, Tamai Y, Oshima M, Taketo MM. Takeda H, et al. Br J Cancer. 2004 Feb 9;90(3):701-4. doi: 10.1038/sj.bjc.6601584. Br J Cancer. 2004. PMID: 14760387 Free PMC article.
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice. ...
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and micr …
15 results