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Page 1
Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis.
Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, Li X, Miao X, Li S, Mi X, Zhang J, Li L, Wei G, Xu ZX, Gao X, Huang C, Wei Z, Goding CR, Wang P, Deng X, Cui R. Yin C, et al. Cell. 2019 Feb 21;176(5):1113-1127.e16. doi: 10.1016/j.cell.2019.01.002. Epub 2019 Jan 31. Cell. 2019. PMID: 30712867 Free article.
Here, we identify a previously uncharacterized serine/threonine kinase STK19 as a novel NRAS activator. STK19 phosphorylates NRAS to enhance its binding to its downstream effectors and promotes oncogenic NRAS-mediated melanocyte malignant transformation. ...STK19 …
Here, we identify a previously uncharacterized serine/threonine kinase STK19 as a novel NRAS activator. STK19 phosphorylates N …
STK19: a new target for NRAS-driven cancer.
Asquith CRM, Temme L. Asquith CRM, et al. Nat Rev Drug Discov. 2020 Sep;19(9):579. doi: 10.1038/d41573-020-00116-x. Nat Rev Drug Discov. 2020. PMID: 32587355 No abstract available.
A landscape of driver mutations in melanoma.
Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DS, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L. Hodis E, et al. Cell. 2012 Jul 20;150(2):251-63. doi: 10.1016/j.cell.2012.06.024. Cell. 2012. PMID: 22817889 Free PMC article.
Analysis of large-scale melanoma exome data by this approach discovered six novel melanoma genes (PPP6C, RAC1, SNX31, TACC1, STK19, and ARID2), three of which-RAC1, PPP6C, and STK19-harbored recurrent and potentially targetable mutations. ...
Analysis of large-scale melanoma exome data by this approach discovered six novel melanoma genes (PPP6C, RAC1, SNX31, TACC1, STK19, a …
African-specific molecular taxonomy of prostate cancer.
Jaratlerdsiri W, Jiang J, Gong T, Patrick SM, Willet C, Chew T, Lyons RJ, Haynes AM, Pasqualim G, Louw M, Kench JG, Campbell R, Horvath LG, Chan EKF, Wedge DC, Sadsad R, Brum IS, Mutambirwa SBA, Stricker PD, Bornman MSR, Hayes VM. Jaratlerdsiri W, et al. Nature. 2022 Sep;609(7927):552-559. doi: 10.1038/s41586-022-05154-6. Epub 2022 Aug 31. Nature. 2022. PMID: 36045292 Free PMC article.
Here, through whole-genome sequencing of treatment-naive prostate cancer samples from 183 ancestrally (African versus European) and globally distinct patients, we generate a large cancer genomics resource for sub-Saharan Africa, identifying around 2 million somatic …
Here, through whole-genome sequencing of treatment-naive prostate cancer samples from 183 ancestrally (African versus European) and g …
Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver.
Rodríguez-Martínez M, Boissiére T, Noe Gonzalez M, Litchfield K, Mitter R, Walker J, Kjœr S, Ismail M, Downward J, Swanton C, Svejstrup JQ. Rodríguez-Martínez M, et al. Cell. 2020 Jun 11;181(6):1395-1405.e11. doi: 10.1016/j.cell.2020.04.014. Cell. 2020. PMID: 32531245 Free PMC article.
STK19 was proposed to be a cancer driver, and recent work by Yin et al. (2019) in Cell suggested that the frequently recurring STK19 D89N substitution represents a gain-of-function change, allowing increased phosphorylation of NRAS to enhance melanocyte trans …
STK19 was proposed to be a cancer driver, and recent work by Yin et al. (2019) in Cell suggested that the frequently recurring …
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ, McKee T, Letourneau A, Ribaux PG, Popadin K, Basset-Seguin N, Ben Chaabene R, Santoni FA, Andrianova MA, Guipponi M, Garieri M, Verdan C, Grosdemange K, Sumara O, Eilers M, Aifantis I, Michielin O, de Sauvage FJ, Antonarakis SE, Nikolaev SI. Bonilla X, et al. Nat Genet. 2016 Apr;48(4):398-406. doi: 10.1038/ng.3525. Epub 2016 Mar 7. Nat Genet. 2016. PMID: 26950094
Our genetic profiling of 293 BCCs found the highest mutation rate in cancer (65 mutations/Mb). Eighty-five percent of the BCCs harbored mutations in Hh pathway genes (PTCH1, 73% or SMO, 20% (P = 6.6 10(-8)) and SUFU, 8%) and in TP53 (61%). However, 85% of the BCCs also har …
Our genetic profiling of 293 BCCs found the highest mutation rate in cancer (65 mutations/Mb). Eighty-five percent of the BCCs harbor …
Annotation matters: validating the discovery of cancer drivers.
Rodríguez-Martínez M, Svejstrup JQ. Rodríguez-Martínez M, et al. Mol Cell Oncol. 2020 Aug 31;7(6):1806679. doi: 10.1080/23723556.2020.1806679. Mol Cell Oncol. 2020. PMID: 33235910 Free PMC article.
Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of STK19 (Serine Threonine Kinase 19), …
Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analy …
Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators.
Qiu Y, Wang Y, Chai Z, Ni D, Li X, Pu J, Chen J, Zhang J, Lu S, Lv C, Ji M. Qiu Y, et al. Acta Pharm Sin B. 2021 Nov;11(11):3433-3446. doi: 10.1016/j.apsb.2021.02.014. Epub 2021 Feb 25. Acta Pharm Sin B. 2021. PMID: 34900528 Free PMC article. Review.
RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for 19% of the global cancer burden. As a well-recognized target in malignancy, RAS has been intensively studied in the past decades. ...
RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for 19% of the global cancer burden. As …
Targeting NRAS-Mutant Cancers with the Selective STK19 Kinase Inhibitor Chelidonine.
Qian L, Chen K, Wang C, Chen Z, Meng Z, Wang P. Qian L, et al. Clin Cancer Res. 2020 Jul 1;26(13):3408-3419. doi: 10.1158/1078-0432.CCR-19-2604. Epub 2020 Mar 10. Clin Cancer Res. 2020. PMID: 32156748
Here, we describe a new pharmacologic inhibitor of STK19 kinase for the treatment of NRAS-mutant cancers. EXPERIMENTAL DESIGN: The STK19 kinase inhibitor was identified from a natural compound library using a luminescent phosphorylation assay as the primary s …
Here, we describe a new pharmacologic inhibitor of STK19 kinase for the treatment of NRAS-mutant cancers. EXPERIMENTAL DESIGN: …
STK19 is a DNA/RNA-binding protein critical for DNA damage repair and cell proliferation.
Li Y, Gong Y, Zhou Y, Xiao Y, Huang W, Zhou Q, Tu Y, Zhao Y, Zhang S, Dai L, Sun Q. Li Y, et al. J Cell Biol. 2024 Feb 5;223(2):e202301090. doi: 10.1083/jcb.202301090. Epub 2024 Jan 22. J Cell Biol. 2024. PMID: 38252411
STK19 also bound double-stranded RNA through the DNA-binding interface and regulated the expression levels of many mRNAs. ...To prevent further confusions, we renamed this protein as TWH19 (Tandem Winged Helix protein formerly known as STK19)....
STK19 also bound double-stranded RNA through the DNA-binding interface and regulated the expression levels of many mRNAs. ...To preve …
19 results