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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
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2003 2
2004 2
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2011 1
2012 1
2013 3
2014 3
2015 3
2017 4
2018 2
2019 3
2020 3
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35 results

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Page 1
STX2 drives colorectal cancer proliferation via upregulation of EXOSC4.
Wang YX, Li YZ, Zhu HF, Zhang ZY, Qian XL, He GY. Wang YX, et al. Life Sci. 2020 Dec 15;263:118597. doi: 10.1016/j.lfs.2020.118597. Epub 2020 Oct 16. Life Sci. 2020. PMID: 33075373
AIMS: To explore the biological function and mechanism of Syntaxin2 (STX2) in Colorectal cancer (CRC) proliferation. MAIN METHODS: A series of gain- and loss-of-function analysis were conducted the to explore the biological function of STX2 in CRC proliferati …
AIMS: To explore the biological function and mechanism of Syntaxin2 (STX2) in Colorectal cancer (CRC) proliferation. MAIN METH …
STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-kappaB pathway.
Wang Y, Xu H, Jiao H, Wang S, Xiao Z, Zhao Y, Bi J, Wei W, Liu S, Qiu J, Li T, Liang L, Ye Y, Liao W, Ding Y. Wang Y, et al. Cell Death Dis. 2018 May 31;9(6):664. doi: 10.1038/s41419-018-0675-x. Cell Death Dis. 2018. PMID: 29855462 Free PMC article.
Furthermore, chromatin immunoprecipitation (ChIP) analysis revealed that NF-kappaB directly bound to the STX2 promoter and drove STX2 transcription. Therefore, STX2 activated the NF-kappaB pathway, and in turn, NF-kappaB increased STX2 expression, form …
Furthermore, chromatin immunoprecipitation (ChIP) analysis revealed that NF-kappaB directly bound to the STX2 promoter and drove S …
Protection against Shiga Toxins.
Kavaliauskiene S, Dyve Lingelem AB, Skotland T, Sandvig K. Kavaliauskiene S, et al. Toxins (Basel). 2017 Feb 3;9(2):44. doi: 10.3390/toxins9020044. Toxins (Basel). 2017. PMID: 28165371 Free PMC article. Review.
Syntaxin 2 promotes colorectal cancer growth by increasing the secretion of exosomes.
Wang Y, Li Y, Zhou H, Qian X, Hu Y. Wang Y, et al. J Cancer. 2021 Feb 2;12(7):2050-2058. doi: 10.7150/jca.51494. eCollection 2021. J Cancer. 2021. PMID: 33754003 Free PMC article.
Background: Colorectal cancer (CRC) is one of the most common cancers with high mortality worldwide. ...Downregulation of STX2 repressed the growth of CRC. STX2 modulated exosomes secretion of CRC cells which might correlated with Rab8a expression. ...
Background: Colorectal cancer (CRC) is one of the most common cancers with high mortality worldwide. ...Downregulation of S …
Pancreatitis-Induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis.
Dolai S, Liang T, Orabi AI, Holmyard D, Xie L, Greitzer-Antes D, Kang Y, Xie H, Javed TA, Lam PP, Rubin DC, Thorn P, Gaisano HY. Dolai S, et al. Gastroenterology. 2018 May;154(6):1805-1821.e5. doi: 10.1053/j.gastro.2018.01.025. Epub 2018 Jan 31. Gastroenterology. 2018. PMID: 29360461 Free PMC article.
Using human pancreatic tissues and STX2-knockout (KO) mice, we investigated the functions of STX2 in zymogen granule-mediated exocytosis and autophagy. ...RESULTS: Human pancreatic tissues and dispersed pancreatic acini from control mice exposed to CCK-8 or ethanol …
Using human pancreatic tissues and STX2-knockout (KO) mice, we investigated the functions of STX2 in zymogen granule-mediated …
Pan-Cancer Multiomics Analysis of TC2N Gene Suggests its Important Role(s) in Tumourigenesis of Many Cancers.
Qureshi MA, Khan S, Tauheed MS, Syed SA, Ujjan ID, Lail A, Sharafat S. Qureshi MA, et al. Asian Pac J Cancer Prev. 2020 Nov 1;21(11):3199-3209. doi: 10.31557/APJCP.2020.21.11.3199. Asian Pac J Cancer Prev. 2020. PMID: 33247676 Free PMC article.
BACKGROUND: Role of TC2N in carcinogenesis has been largely unfathomed until recently when it was identified as a novel oncogene in lung cancer. Subsequently, a tumour suppressor role of TC2N was reported in breast cancer. ...METHODS: We investigated TC2N mRNA expre …
BACKGROUND: Role of TC2N in carcinogenesis has been largely unfathomed until recently when it was identified as a novel oncogene in lung …
Screening and regulatory network analysis of survival-related genes of patients with colorectal cancer.
Qi L, Ding Y. Qi L, et al. Sci China Life Sci. 2014 May;57(5):526-31. doi: 10.1007/s11427-014-4650-1. Epub 2014 Apr 11. Sci China Life Sci. 2014. PMID: 24722856
Through the above analysis, six upregulated genes in colorectal cancer related to the survival of colorectal cancer patients and highly regulated by transcription factors were selected, namely STX2, PODXL, KLK6, GRB10, EHBP1 and CREB5. These genes are involve …
Through the above analysis, six upregulated genes in colorectal cancer related to the survival of colorectal cancer patients a …
Epimorphin-induced MET sensitizes ovarian cancer cells to platinum.
Yew KH, Crow J, Hirst J, Pessetto Z, Godwin AK. Yew KH, et al. PLoS One. 2013 Sep 9;8(9):e72637. doi: 10.1371/journal.pone.0072637. eCollection 2013. PLoS One. 2013. PMID: 24039787 Free PMC article.
Distinctive genotypic and phenotypic features of ovarian cancer via epithelial-mesenchymal transition (EMT) have been correlated with drug resistance and disease recurrence. We investigated whether therapeutic reversal of EMT could re-sensitize ovarian cancer cells …
Distinctive genotypic and phenotypic features of ovarian cancer via epithelial-mesenchymal transition (EMT) have been correlated with …
Mucosa-Associated Escherichia coli in Colorectal Cancer Patients and Control Subjects: Variations in the Prevalence and Attributing Features.
Nouri R, Hasani A, Masnadi Shirazi K, Alivand MR, Sepehri B, Sotoudeh S, Hemmati F, Fattahzadeh A, Abdinia B, Ahangarzadeh Rezaee M. Nouri R, et al. Can J Infect Dis Med Microbiol. 2021 Nov 9;2021:2131787. doi: 10.1155/2021/2131787. eCollection 2021. Can J Infect Dis Med Microbiol. 2021. PMID: 34795808 Free PMC article.
This study aimed to investigate the prevalence and characterization of mucosa-associated E. coli obtained from the colorectal cancer (CRC) patients and control group. At two referral university-affiliated hospitals in northwest Iran, 100 patients, 50 with CRC and 50 withou …
This study aimed to investigate the prevalence and characterization of mucosa-associated E. coli obtained from the colorectal cancer …
Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking.
Selyunin AS, Iles LR, Bartholomeusz G, Mukhopadhyay S. Selyunin AS, et al. J Cell Biol. 2017 Oct 2;216(10):3249-3262. doi: 10.1083/jcb.201704015. Epub 2017 Sep 7. J Cell Biol. 2017. PMID: 28883040 Free PMC article.
Targeting this trafficking step has therapeutic promise, but the mechanism of trafficking for the more potent toxin STx2 is unclear. To identify host factors required for early endosome-to-Golgi trafficking of STx2, we performed a viability-based genome-wide siRNA s …
Targeting this trafficking step has therapeutic promise, but the mechanism of trafficking for the more potent toxin STx2 is unclear. …
35 results