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ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.
Wang J, Luo J, Wu X, Li Z. Wang J, et al. Hum Cell. 2022 Nov;35(6):1961-1975. doi: 10.1007/s13577-022-00789-z. Epub 2022 Sep 15. Hum Cell. 2022. PMID: 36107384
Further analysis revealed that ELK1 synergized with histone deacetylase 2 (HDAC2) to specifically bind to the synaptotagmin like 1 (SYTL1) promoter, thereby repressing SYTL1 transcription and protein expression. Depletion of SYTL1 reversed the repressive effe …
Further analysis revealed that ELK1 synergized with histone deacetylase 2 (HDAC2) to specifically bind to the synaptotagmin like 1 (SYTL1 …
LincRNA01703 Facilitates CD81(+) Exosome Secretion to Inhibit Lung Adenocarcinoma Metastasis via the Rab27a/SYTL1/CD81 Complex.
Huang Y, Guo S, Lin Y, Huo L, Yan H, Lin Z, Chen Z, Cai J, Wu J, Yuan J, Guan H, Wu G, Wu W, Tao T. Huang Y, et al. Cancers (Basel). 2023 Dec 9;15(24):5781. doi: 10.3390/cancers15245781. Cancers (Basel). 2023. PMID: 38136327 Free PMC article.
Metastasis, a major cause of cancer-related mortality worldwide, frequently occurs early in the diagnosis of lung adenocarcinoma (LUAD). ...Mechanistically, Linc01703 enhanced the interaction between Rab27a, SYTL1, and CD81, consequently promoting the secretion of C …
Metastasis, a major cause of cancer-related mortality worldwide, frequently occurs early in the diagnosis of lung adenocarcinoma (LUA …
WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in bladder cancer.
Wang J, Luo J, Wu X, Li Z. Wang J, et al. Histol Histopathol. 2024 May;39(5):633-646. doi: 10.14670/HH-18-671. Epub 2023 Oct 23. Histol Histopathol. 2024. PMID: 37933909
BACKGROUND: Bladder cancer (BCa) is the most frequent type of cancer in humans. The association between m6A modification and the anti-tumor effects of natural killer (NK) cells has been described in BCa. ...METHODS: The prognostic role of SYTL1 in BCa was inv …
BACKGROUND: Bladder cancer (BCa) is the most frequent type of cancer in humans. The association between m6A modification and t …
Exploration of Prognostic Biomarkers of Muscle-Invasive Bladder Cancer (MIBC) by Bioinformatics.
Xu X, Wang Y, Zhang S, Zhu Y, Wang J. Xu X, et al. Evol Bioinform Online. 2021 Oct 28;17:11769343211049270. doi: 10.1177/11769343211049270. eCollection 2021. Evol Bioinform Online. 2021. PMID: 34733102 Free PMC article.
Online data of MIBC were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus database (GEO) database. ...MIBC samples from TCGA and GEO were analyzed by WGCNA and univariate Cox analysis and intersected at 4 genes, CLK4, DEDD2, ENO1, and SYTL1. …
Online data of MIBC were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus database (GEO) database. ...MIBC sa …
Synaptotagmin-like protein 1 is a potential diagnostic and prognostic biomarker in endometrial cancer based on bioinformatics and experiments.
Meijuan C, Meng X, Fang L, Qian W. Meijuan C, et al. J Ovarian Res. 2023 Jan 19;16(1):16. doi: 10.1186/s13048-023-01097-2. J Ovarian Res. 2023. PMID: 36653850 Free PMC article.
And increased expression of SYTL1 was associated with age, clinical stage, histological type, histological grade and good overall survival (OS).SYTL1 DNA methylation is negatively associated with SYTL1 expression and UCEC patients' OS. SYTL1 expression …
And increased expression of SYTL1 was associated with age, clinical stage, histological type, histological grade and good overall sur …
Deregulation of Rab and Rab effector genes in bladder cancer.
Ho JR, Chapeaublanc E, Kirkwood L, Nicolle R, Benhamou S, Lebret T, Allory Y, Southgate J, Radvanyi F, Goud B. Ho JR, et al. PLoS One. 2012;7(6):e39469. doi: 10.1371/journal.pone.0039469. Epub 2012 Jun 19. PLoS One. 2012. PMID: 22724020 Free PMC article.
This systematic analysis of Rab and Rab effector gene deregulation in bladder cancer, taking relevant tumor subgroups into account, provides insight into the possible roles of Rab proteins and their effectors in bladder cancer pathogenesis. This approach is applicab …
This systematic analysis of Rab and Rab effector gene deregulation in bladder cancer, taking relevant tumor subgroups into account, p …
MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.
Yokoyama T, Nakatake M, Kuwata T, Couzinet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJ, Delwel R, Nakamura T. Yokoyama T, et al. J Clin Invest. 2016 May 2;126(5):1664-78. doi: 10.1172/JCI81516. Epub 2016 Mar 28. J Clin Invest. 2016. PMID: 27018596 Free PMC article.
Replacement of SYTL1 in MEIS1-deficent cells restored both cell migration and engraftment. Further analysis revealed that SYTL1 promotes cell migration via activation of the CXCL12/CXCR4 axis, as SYTL1 determines intracellular trafficking of CXCR4. ...
Replacement of SYTL1 in MEIS1-deficent cells restored both cell migration and engraftment. Further analysis revealed that SYTL1 …
Development and verification of a hypoxia- and immune-associated prognosis signature for esophageal squamous cell carcinoma.
Lian L, Teng SB, Xia YY, Shen XM, Zheng Y, Han SG, Wang WJ, Xu XF, Zhou C. Lian L, et al. J Gastrointest Oncol. 2022 Apr;13(2):462-477. doi: 10.21037/jgo-22-69. J Gastrointest Oncol. 2022. PMID: 35557566 Free PMC article.
BACKGROUND: Esophageal cancer is one of the most common gastrointestinal malignancies worldwide, with high morbidity and mortality in China. ...METHODS: The RNA-sequencing and clinical data of 173 cases of ESCC and 271 normal tissues were obtained from The Cancer Ge …
BACKGROUND: Esophageal cancer is one of the most common gastrointestinal malignancies worldwide, with high morbidity and mortality in …
In Vitro Fluorescence Resonance Energy Transfer-Based Assay Used to Determine the Rab27-Effector-Binding Affinity.
Al-Saad RZ, Kerr I, Hume AN. Al-Saad RZ, et al. Assay Drug Dev Technol. 2020 May/Jun;18(4):180-194. doi: 10.1089/adt.2019.960. Epub 2020 May 7. Assay Drug Dev Technol. 2020. PMID: 32384245
In recent years, a number of studies have identified roles for Rab27 proteins and their effectors in cancer cell invasion and metastasis, immune response, inflammation, and allergic responses. ...
In recent years, a number of studies have identified roles for Rab27 proteins and their effectors in cancer cell invasion and metasta …
Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells.
Catz SD. Catz SD. Methods Enzymol. 2008;438:25-40. doi: 10.1016/S0076-6879(07)38003-8. Methods Enzymol. 2008. PMID: 18413239
Prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are produced by prostate carcinoma cells. Their secretion has implications in both prostate cancer diagnosis and progression. The mechanisms involved in PSA and PSAP secretion in response to andr …
Prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are produced by prostate carcinoma cells. Their secretion has …
12 results