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SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.
Li Z, Tao Y, Gao Z, Peng S, Lai Y, Li K, Chen X, Huang H. Li Z, et al. J Transl Med. 2023 May 5;21(1):303. doi: 10.1186/s12967-023-04146-y. J Transl Med. 2023. PMID: 37147713 Free PMC article.
BACKGROUND: Metastatic prostate cancer (mPCa) has a poor prognosis with limited treatment options. ...Targeting FSCN1 enabled rescue and reversal of the oncogenic effect of SYTL2. CONCLUSIONS: Overall, our study established an FSCN1-dependent mechanism by which S …
BACKGROUND: Metastatic prostate cancer (mPCa) has a poor prognosis with limited treatment options. ...Targeting FSCN1 enabled rescue …
Comprehensive profiling of 1015 patients' exomes reveals genomic-clinical associations in colorectal cancer.
Zhao Q, Wang F, Chen YX, Chen S, Yao YC, Zeng ZL, Jiang TJ, Wang YN, Wu CY, Jing Y, Huang YS, Zhang J, Wang ZX, He MM, Pu HY, Mai ZJ, Wu QN, Long R, Zhang X, Huang T, Xu M, Qiu MZ, Luo HY, Li YH, Zhang DS, Jia WH, Chen G, Ding PR, Li LR, Lu ZH, Pan ZZ, Xu RH. Zhao Q, et al. Nat Commun. 2022 Apr 29;13(1):2342. doi: 10.1038/s41467-022-30062-8. Nat Commun. 2022. PMID: 35487942 Free PMC article.
The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. ...We identify 46 high-confident significantly mutated genes, 8 of which mutate in 14.9% of patients: LYST, DAPK …
The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targete …
Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer.
Sung HY, Han J, Ju W, Ahn JH. Sung HY, et al. Oncol Rep. 2016 Jul;36(1):535-41. doi: 10.3892/or.2016.4835. Epub 2016 May 24. Oncol Rep. 2016. PMID: 27220283
Ovarian cancer (OC) metastasis has unique biological behavior and most commonly occurs via the transcoelomic route. ...The mRNA expression of SYTL2 was significantly upregulated and the methylation of specific CpG sites within the SYTL2 promoter was decreased …
Ovarian cancer (OC) metastasis has unique biological behavior and most commonly occurs via the transcoelomic route. ...The mRNA expre …
ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma.
Tanaka M, Chuaychob S, Homme M, Yamazaki Y, Lyu R, Yamashita K, Ae K, Matsumoto S, Kumegawa K, Maruyama R, Qu W, Miyagi Y, Yokokawa R, Nakamura T. Tanaka M, et al. Nat Commun. 2023 Apr 7;14(1):1957. doi: 10.1038/s41467-023-37049-z. Nat Commun. 2023. PMID: 37029109 Free PMC article.
Using epigenomic CRISPR/dCas9 screening, we identify Pdgfb, Rab27a, Sytl2, and Vwf as critical targets associated with reduced enhancer activities due to the ASPSCR1::TFE3 loss. Upregulation of Rab27a and Sytl2 promotes angiogenic factor-trafficking to facilitate AS …
Using epigenomic CRISPR/dCas9 screening, we identify Pdgfb, Rab27a, Sytl2, and Vwf as critical targets associated with reduced enhanc …
Deregulation of Rab and Rab effector genes in bladder cancer.
Ho JR, Chapeaublanc E, Kirkwood L, Nicolle R, Benhamou S, Lebret T, Allory Y, Southgate J, Radvanyi F, Goud B. Ho JR, et al. PLoS One. 2012;7(6):e39469. doi: 10.1371/journal.pone.0039469. Epub 2012 Jun 19. PLoS One. 2012. PMID: 22724020 Free PMC article.
This systematic analysis of Rab and Rab effector gene deregulation in bladder cancer, taking relevant tumor subgroups into account, provides insight into the possible roles of Rab proteins and their effectors in bladder cancer pathogenesis. This approach is applicab …
This systematic analysis of Rab and Rab effector gene deregulation in bladder cancer, taking relevant tumor subgroups into account, p …
Long noncoding RNA BSN-AS2 induced by E2F1 promotes spinal osteosarcoma progression by targeting miR-654-3p/SYTL2 axis.
Zhou X, Li J, Teng J, Liu Y, Zhang D, Liu L, Zhang W. Zhou X, et al. Cancer Cell Int. 2020 Apr 25;20:133. doi: 10.1186/s12935-020-01205-y. eCollection 2020. Cancer Cell Int. 2020. PMID: 32351327 Free PMC article.
Long noncoding RNA (lncRNA) BSN-AS2 has been shown to be an oncogenic gene in several cancers. However, the role and function of BSN-AS2 in spinal OS were unfamiliar. ...In conclusion, the availability of miR-654-3p was antagonized by E2F1-induced BSN-AS2 for SYTL2- …
Long noncoding RNA (lncRNA) BSN-AS2 has been shown to be an oncogenic gene in several cancers. However, the role and function of BSN- …
Molecular insights into the development of hepatic metastases in colorectal cancer: a metastasis prediction study.
Yang J, Kim H, Shin K, Nam Y, Heo HJ, Kim GH, Hwang BY, Kim J, Woo S, Choi HS, Ko DS, Lee D, Kim YH. Yang J, et al. Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):12701-12708. doi: 10.26355/eurrev_202012_24168. Eur Rev Med Pharmacol Sci. 2020. PMID: 33378017 Free article.
OBJECTIVE: Colorectal cancer is presently the third most commonly diagnosed cancer in the United States. ...CONCLUSIONS: This study reveals the biological mechanisms underlying hepatic metastases in colorectal cancer and will help in developing targeted thera …
OBJECTIVE: Colorectal cancer is presently the third most commonly diagnosed cancer in the United States. ...CONCLUSIONS: This …
Construction of prognostic risk prediction model of oral squamous cell carcinoma based on co-methylated genes.
Zhu Q, Tian G, Gao J. Zhu Q, et al. Int J Mol Med. 2019 Sep;44(3):787-796. doi: 10.3892/ijmm.2019.4243. Epub 2019 Jun 13. Int J Mol Med. 2019. PMID: 31198983 Free PMC article.
For this purpose, the methylation data of patients with OSCC downloaded from The Cancer Genome Atlas were considered as a training dataset. The methylation profiles of GSE37745 for OSCC samples were downloaded from Gene Expression Omnibus and considered as validation datas …
For this purpose, the methylation data of patients with OSCC downloaded from The Cancer Genome Atlas were considered as a training da …
Diseasome and comorbidities complexities of SARS-CoV-2 infection with common malignant diseases.
Satu MS, Khan MI, Rahman MR, Howlader KC, Roy S, Roy SS, Quinn JMW, Moni MA. Satu MS, et al. Brief Bioinform. 2021 Mar 22;22(2):1415-1429. doi: 10.1093/bib/bbab003. Brief Bioinform. 2021. PMID: 33539530 Free PMC article.
In this study, we aimed to identify infectome, diseasome and comorbidities between COVID-19 and cancer via comprehensive bioinformatics analysis to identify the synergistic severity of the cancer patient for SARS-CoV-2 infection. ...Our bioinformatics approach revea …
In this study, we aimed to identify infectome, diseasome and comorbidities between COVID-19 and cancer via comprehensive bioinformati …
Daphnane diterpenes inhibit the metastatic potential of B16F10 murine melanoma cells in vitro and in vivo.
Villareal MO, Sato Y, Matsuyama K, Isoda H. Villareal MO, et al. BMC Cancer. 2018 Aug 29;18(1):856. doi: 10.1186/s12885-018-4693-y. BMC Cancer. 2018. PMID: 30157785 Free PMC article.
BACKGROUND: Melanoma is one of the most invasive and aggressive types of cancer with a very poor prognosis. Surgery remains the most efficient treatment prior melanoma invasion and metastasis formation. ...In this respect, it is important to continue to discover new can …
BACKGROUND: Melanoma is one of the most invasive and aggressive types of cancer with a very poor prognosis. Surgery remains the most …
14 results