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A controlled, randomized phase II clinical trial for efficacy and safety evaluation of mannuronic acid in secondary progressive form of multiple sclerosis.
Najafi S, Moghadam NB, Saadat P, Noorbakhsh SM, Mohammadi AV, Manouchehrinia A, Hosseini M, Matsuo H, Mirshafiey A. Najafi S, et al. Among authors: saadat p. Int J Neurosci. 2022 Apr;132(4):403-412. doi: 10.1080/00207454.2020.1818741. Epub 2020 Sep 7. Int J Neurosci. 2022. PMID: 32878514 Clinical Trial.
Evaluation of the Effect of Mannuronic Acid as a Novel NSAID With Immunosuppressive Properties on Expression of SOCS1, SOCS3, SHIP1, and TRAF6 Genes and Serum Levels of IL-6 and TNF-α in Patients With Multiple Sclerosis.
Najafi S, Saadat P, Beladi Moghadam N, Manoucherinia A, Aghazadeh Z, Vali Mohammadi A, Pashaiefar H, Hosseini M, Mirshafiey A. Najafi S, et al. Among authors: saadat p. J Clin Pharmacol. 2021 Oct;61(10):1303-1310. doi: 10.1002/jcph.1879. Epub 2021 Aug 2. J Clin Pharmacol. 2021. PMID: 33908653
The Effects of Mannuronic Acid on IL-1β, IL-17A, STAT1, and STAT3 Gene Expressions and TLR2 and TLR4 Molecules in Multiple Sclerosis.
Najafi S, Saadat P, Beladi Moghadam N, Manoucherinia A, Aghazadeh Z, Vali Mohammadi A, Noorbakhsh SM, Movahedi M, Nikouei Moghaddam MR, Pashaiefar H, Mirshafiey A. Najafi S, et al. Among authors: saadat p. J Clin Pharmacol. 2022 Jun;62(6):762-769. doi: 10.1002/jcph.2008. Epub 2022 Jan 7. J Clin Pharmacol. 2022. PMID: 34825387
Decreased frequency of regulatory T cells and level of helios gene expression in secondary progressive multiple sclerosis patients: Evidence about the development of multiple sclerosis.
Tarighi M, Shahbazi M, Saadat P, Daraei A, Alizadeh Khatir A, Rahimifard K, Mohammadnia-Afrouzi M. Tarighi M, et al. Among authors: saadat p. Int Immunopharmacol. 2023 Mar;116:109797. doi: 10.1016/j.intimp.2023.109797. Epub 2023 Feb 2. Int Immunopharmacol. 2023. PMID: 36738680
77 results