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Page 1
Development of an mRNA replacement therapy for phenylketonuria.
Perez-Garcia CG, Diaz-Trelles R, Vega JB, Bao Y, Sablad M, Limphong P, Chikamatsu S, Yu H, Taylor W, Karmali PP, Tachikawa K, Chivukula P. Perez-Garcia CG, et al. Among authors: sablad m. Mol Ther Nucleic Acids. 2022 Feb 28;28:87-98. doi: 10.1016/j.omtn.2022.02.020. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35356682 Free PMC article.
Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model.
Diaz-Trelles R, Lee S, Kuakini K, Park J, Dukanovic A, Gonzalez JA, Dam T, Kim JH, Vega JB, Sablad M, Karmali PP, Tachikawa K, Chivukula P. Diaz-Trelles R, et al. Among authors: sablad m. Mol Genet Metab Rep. 2022 May 14;32:100882. doi: 10.1016/j.ymgmr.2022.100882. eCollection 2022 Sep. Mol Genet Metab Rep. 2022. PMID: 35600090 Free PMC article.
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.
de Alwis R, Gan ES, Chen S, Leong YS, Tan HC, Zhang SL, Yau C, Low JGH, Kalimuddin S, Matsuda D, Allen EC, Hartman P, Park KJ, Alayyoubi M, Bhaskaran H, Dukanovic A, Bao Y, Clemente B, Vega J, Roberts S, Gonzalez JA, Sablad M, Yelin R, Taylor W, Tachikawa K, Parker S, Karmali P, Davis J, Sullivan BM, Sullivan SM, Hughes SG, Chivukula P, Ooi EE. de Alwis R, et al. Among authors: sablad m. Mol Ther. 2021 Jun 2;29(6):1970-1983. doi: 10.1016/j.ymthe.2021.04.001. Epub 2021 Apr 5. Mol Ther. 2021. PMID: 33823303 Free PMC article.
Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA.
Rajappan K, Tanis SP, Mukthavaram R, Roberts S, Nguyen M, Tachikawa K, Sagi A, Sablad M, Limphong P, Leu A, Yu H, Chivukula P, Payne JE, Karmali P. Rajappan K, et al. Among authors: sablad m. J Med Chem. 2020 Nov 12;63(21):12992-13012. doi: 10.1021/acs.jmedchem.0c01407. Epub 2020 Oct 29. J Med Chem. 2020. PMID: 33119286
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
Payne JE, Bonnefous C, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND. Payne JE, et al. Among authors: sablad m. J Med Chem. 2010 Nov 11;53(21):7739-55. doi: 10.1021/jm100828n. J Med Chem. 2010. PMID: 20931971
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND. Bonnefous C, et al. Among authors: sablad m. J Med Chem. 2009 May 14;52(9):3047-62. doi: 10.1021/jm900173b. J Med Chem. 2009. PMID: 19374401
Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS. Symons KT, et al. Among authors: sablad m. J Pharmacol Exp Ther. 2011 Feb;336(2):468-78. doi: 10.1124/jpet.110.172817. Epub 2010 Oct 29. J Pharmacol Exp Ther. 2011. PMID: 21036913
Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.
Durón SG, Lindstrom A, Bonnefous C, Zhang H, Chen X, Symons KT, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND. Durón SG, et al. Among authors: sablad m. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1237-41. doi: 10.1016/j.bmcl.2011.11.073. Epub 2011 Nov 25. Bioorg Med Chem Lett. 2012. PMID: 22182498
18 results