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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 3
1966 2
1967 1
1968 1
1969 1
1970 4
1971 4
1972 2
1973 2
1974 1
1975 5
1976 7
1977 1
1978 10
1979 6
1980 5
1981 3
1982 3
1983 2
1984 6
1985 5
1986 4
1987 5
1988 2
1989 3
1990 8
1991 2
1992 3
1993 1
1994 5
1995 3
1996 2
1997 4
1998 5
1999 4
2000 10
2001 5
2002 4
2003 6
2004 5
2005 5
2006 8
2007 7
2008 8
2009 6
2010 7
2011 6
2012 9
2013 10
2014 5
2015 13
2016 10
2017 6
2018 2
2019 10
2020 16
2021 12
2022 14
2023 15
2024 1

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302 results

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Page 1
Lysine Catabolism Through the Saccharopine Pathway: Enzymes and Intermediates Involved in Plant Responses to Abiotic and Biotic Stress.
Arruda P, Barreto P. Arruda P, et al. Front Plant Sci. 2020 May 21;11:587. doi: 10.3389/fpls.2020.00587. eCollection 2020. Front Plant Sci. 2020. PMID: 32508857 Free PMC article. Review.
The saccharopine pathway (SACPATH) involves the conversion of lysine into alpha-aminoadipate by three enzymatic reactions catalyzed by the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) and the enzyme alpha-aminoadipate semia …
The saccharopine pathway (SACPATH) involves the conversion of lysine into alpha-aminoadipate by three enzymatic reactions catalyzed b …
The Metabolite Saccharopine Impairs Neuronal Development by Inhibiting the Neurotrophic Function of Glucose-6-Phosphate Isomerase.
Guo Y, Wu J, Wang M, Wang X, Jian Y, Yang C, Guo W. Guo Y, et al. J Neurosci. 2022 Mar 30;42(13):2631-2646. doi: 10.1523/JNEUROSCI.1459-21.2022. Epub 2022 Feb 8. J Neurosci. 2022. PMID: 35135854 Free PMC article.
Furthermore, saccharopine impairs neuronal development by inhibiting the neurotrophic effect of glucose-6-phosphate isomerase (GPI). These findings demonstrate saccharopine degradation is essential for neuronal development....
Furthermore, saccharopine impairs neuronal development by inhibiting the neurotrophic effect of glucose-6-phosphate isomerase (GPI). …
The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis.
Zhou J, Wang X, Wang M, Chang Y, Zhang F, Ban Z, Tang R, Gan Q, Wu S, Guo Y, Zhang Q, Wang F, Zhao L, Jing Y, Qian W, Wang G, Guo W, Yang C. Zhou J, et al. J Cell Biol. 2019 Feb 4;218(2):580-597. doi: 10.1083/jcb.201807204. Epub 2018 Dec 20. J Cell Biol. 2019. PMID: 30573525 Free PMC article.
In Caenorhbditis elegans, mutations in the saccharopine dehydrogenase (SDH) domain of the bi-functional enzyme alpha-aminoadipic semialdehyde synthase AASS-1 greatly elevate the lysine catabolic intermediate saccharopine, which causes mitochondrial damage by disrupt …
In Caenorhbditis elegans, mutations in the saccharopine dehydrogenase (SDH) domain of the bi-functional enzyme alpha-aminoadipic semi …
Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin.
Leandro J, Houten SM. Leandro J, et al. J Cell Biol. 2019 Feb 4;218(2):391-392. doi: 10.1083/jcb.201901033. Epub 2019 Jan 16. J Cell Biol. 2019. PMID: 30651301 Free PMC article.
Saccharopine, a nonproteinogenic amino acid originally isolated from the yeast Saccharomyces cerevisiae, is an intermediate in lysine metabolism. ...Cell Biol. https://doi.org./10.1083/jcb.201807204) show that abnormal accumulation of saccharopine results in defecti …
Saccharopine, a nonproteinogenic amino acid originally isolated from the yeast Saccharomyces cerevisiae, is an intermediate in lysine …
Review of Lysine Metabolism with a Focus on Humans.
Matthews DE. Matthews DE. J Nutr. 2020 Oct 1;150(Suppl 1):2548S-2555S. doi: 10.1093/jn/nxaa224. J Nutr. 2020. PMID: 33000162 Free article. Review.
The first step in the lysine catabolic pathway is the formation of saccharopine and then 2-aminoadipic acid, processes that are mitochondrial. ...
The first step in the lysine catabolic pathway is the formation of saccharopine and then 2-aminoadipic acid, processes that are mitoc …
Integrative physiology of lysine metabolites.
Tan Y, Chrysopoulou M, Rinschen MM. Tan Y, et al. Physiol Genomics. 2023 Dec 1;55(12):579-586. doi: 10.1152/physiolgenomics.00061.2023. Epub 2023 Oct 2. Physiol Genomics. 2023. PMID: 37781739 Review.
Here, we provide an update on integrative physiology of mammalian lysine metabolites such as alpha-aminoadipic acid, saccharopine, pipecolic acid, and lysine conjugates such as acetyl-lysine, and sugar-lysine conjugates such as advanced glycation end products. ...
Here, we provide an update on integrative physiology of mammalian lysine metabolites such as alpha-aminoadipic acid, saccharopine, pi …
The saccharopine pathway in seed development and stress response of maize.
Kiyota E, Pena IA, Arruda P. Kiyota E, et al. Plant Cell Environ. 2015 Nov;38(11):2450-61. doi: 10.1111/pce.12563. Epub 2015 Jul 16. Plant Cell Environ. 2015. PMID: 25929294 Free article.
Lysine is catabolized in developing plant tissues through the saccharopine pathway. In this pathway, lysine is converted into alpha-aminoadipic semialdehyde (AASA) by the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH). ...The …
Lysine is catabolized in developing plant tissues through the saccharopine pathway. In this pathway, lysine is converted into alpha-a …
Saccharopinuria.
Simell O, Visakorpi JK, Donner M. Simell O, et al. Arch Dis Child. 1972 Feb;47(251):52-5. doi: 10.1136/adc.47.251.52. Arch Dis Child. 1972. PMID: 5018656 Free PMC article.
A girl with spastic diplegia excreted large amounts of lysine and saccharopine in the urine, and had more than 10 times the normal plasma lysine concentration and a saccharopine peak in the plasma amino acid chromatogram. ...This case affords further evidence that t …
A girl with spastic diplegia excreted large amounts of lysine and saccharopine in the urine, and had more than 10 times the normal pl …
Spermidine Synthase and Saccharopine Reductase Have Co-Expression Patterns Both in Basidiomycetes with Fusion Form and Ascomycetes with Separate Form.
Yang Y, Shi L, Xu X, Wen J, Xie T, Li H, Li X, Chen M, Dou X, Yuan C, Song H, Xie B, Tao Y. Yang Y, et al. J Fungi (Basel). 2023 Mar 14;9(3):352. doi: 10.3390/jof9030352. J Fungi (Basel). 2023. PMID: 36983520 Free PMC article.
Unlike most harmful fusion genes in cancer cells, in this study, we first found that spermidine synthetase- (SPDS, catalyst of spermidine biosynthesis) and saccharopine reductase- (SR, catalyst of the penultimate step of lysine biosynthesis) encoding genes form a natural c …
Unlike most harmful fusion genes in cancer cells, in this study, we first found that spermidine synthetase- (SPDS, catalyst of spermidine bi …
Enzymatic measurement of saccharopine with saccharopine dehydrogenase.
Simonson MS, Eckel RE. Simonson MS, et al. Anal Biochem. 1985 May 15;147(1):230-3. doi: 10.1016/0003-2697(85)90032-6. Anal Biochem. 1985. PMID: 3927777
We have developed an enzymatic method for measuring saccharopine, a key intermediate in lysine metabolism. With the enzyme saccharopine dehydrogenase, saccharopine can be oxidized to lysine and alpha-ketoglutarate with the corresponding conversion of NAD to N …
We have developed an enzymatic method for measuring saccharopine, a key intermediate in lysine metabolism. With the enzyme sacchar …
302 results